A5092343521- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
Sorbonne Université
2024
Institut Curie
2023-2024
Université Paris Sciences et Lettres
2023-2024
Centre National de la Recherche Scientifique
2023-2024
DNA methylation (DNAme) is a key epigenetic mark that regulates critical biological processes maintaining overall genome stability. Given its pleiotropic function, studies of DNAme dynamics are crucial, but currently available tools to interfere with have limitations and major cytotoxic side effects. Here, we present cell models allow inducible reversible modulation through DNMT1 depletion. By dynamically assessing whole locus-specific effects induced passive demethylation divisions, reveal...
ABSTRACT DNA methylation (DNAme) is a key epigenetic mark that regulates critical biological processes maintaining overall genome stability. Given its pleiotropic function, studies of DNAme dynamics are crucial, but currently available tools to interfere with have limitations and major cytotoxic side effects. Here, we present untransformed cancer cell models allow inducible reversible global modulation through DNMT1 depletion. By dynamically assessing the effects induced passive...