A5101463179- Hip and Femur Fractures
- Bone fractures and treatments
- Orthopaedic implants and arthroplasty
- Sexual function and dysfunction studies
- Pelvic and Acetabular Injuries
- Venous Thromboembolism Diagnosis and Management
- Orthopedic Surgery and Rehabilitation
- MicroRNA in disease regulation
- Cardiac, Anesthesia and Surgical Outcomes
- Total Knee Arthroplasty Outcomes
- Bipolar Disorder and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Ferroptosis and cancer prognosis
- Blood transfusion and management
- Genetics and Neurodevelopmental Disorders
- Circular RNAs in diseases
- Artificial Intelligence in Healthcare and Education
- Periodontal Regeneration and Treatments
- Lung Cancer Treatments and Mutations
- Ultrasound and Hyperthermia Applications
- Sexuality, Behavior, and Technology
- Foot and Ankle Surgery
First Affiliated Hospital of Nanchang University
2016-2024
Nanchang University
2016-2024
Tianjin Hospital
2011-2024
Jiangxi Maternal and Child Health Hospital
2024
Tianjin University
2023
Anhui University of Traditional Chinese Medicine
2021
Hubei University of Technology
2020
University of Benin
2020
Nanjing University of Chinese Medicine
2018
81th Hospital of PLA
2018
Renal cell carcinoma (RCC) is a malignant tumor, which severely threatens human's life, moreover, the multi-drug resistance (MDR) under RCC undoubtedly strengthen difficulties in treatment. MiR-451 has been considered to play an important role regulation of MDR several cancers, but it not explored. This study aims explore mechanism miR-451 as target regulate chemotherapy resistance, crucial for further exploring novel therapy RCC. Two human lines (ACHN and GRC-1) were performed this...
Objective To compare the clinical therapeutic effect of transverse cancellous lag screw (TCLS) fixations and ordinary cannulated (OCS) for vertical femoral neck fractures. Methods A total 62 eligible patients with an average age 56.2 years (range, 19–45 years; 40 male 22 female) Pauwels’ type III fractures were recruited in our study from January 2016 to December 2017. Among patients, 30 underwent TCLS fixation (TCLS group), others treated OCS (OCS group). The baseline data, perioperative...
Opiates produce a strong rewarding effect, but abstinence from opiate use emerges with severe negative emotions. Depression is one of the most frequent emotion disorders associated abstinence, which thought to be main cause for relapse. However, neurobiological bases such an aversive processing are poorly understood. Here, we find that morphine activates κ-opioid receptors (KORs) by increasing endogenous KOR ligand dynorphin expression in amygdala, turn facilitates glutamate transporter 1...
Osteoarthritis (OA) acts as the most common type of degenerative joint disease. Long noncoding RNA (lncRNA) has been identified to regulate apoptosis and proliferation chondrocyte. However, deepgoing mechanism involved in regulation is still unclear. This research aims investigate role molecular by which lncRNA LINC00511 regulates OA biology. Functionally, functional experiments found that expression was upregulated IL-1β-stimulated chondrocyte (ATDC5). Knockdown facilitated proliferation,...
The identification of markers for disease diagnostic, prognostic, or predictive purposes will have a great effect in improving patient management. Proteomic‑based approaches biomarker discovery are promising strategies used cancer research. In this study, we performed quantitative proteomic analysis on four patients including clear cell renal carcinoma (ccRCC) and paired adjacent non‑cancerous tissues using label‑free proteomics liquid chromatography‑tandem mass spectrometry (LC‑MS/MS) to...
Objective The current investigation sought to utilize finite element analysis replicate the biomechanical effects of different fixation methods, with objective establishing a theoretical framework for optimal choice modalities in managing Pauwels type III femoral neck fractures. Methods fracture configuration, characterized by angles 70°, was simulated conjunction six distinct internal including cannulated compression screw (CCS), dynamic hip (DHS), DHS de‐rotational (DS), CCS medial...
The study aimed to explore the effects of B cell lymphoma-2 (Bcl-2)-modified bone marrow-derived mesenchymal stem cells (BMSCs) transplantation for treatment diabetes mellitus-induced erectile dysfunction (DMED) in a rat model.The DMED model was successfully established. Thirty-six rats were assigned into Bcl-2-BMSCs, null-BMSCs, BMSCs and phosphate buffered saline (PBS) groups. Meanwhile, 9 normal injected with PBS taken as control group.In Bcl-2-BMSCs group, average times erection, rate...
Objective: CAM2028 (Episil ® ; Camurus AB, Lund, Sweden) is a liquid for use in the oral cavity to treat various pains associated with mouth injuries. Upon contact swollen mucosa, forms thin protective film that acts as mechanical barrier relieve pain. This study was first China evaluate local analgesic effect of cancer patients who developed mucositis following chemotherapy and/or radiotherapy. Methods: A total 60 were randomized 1:1 ratio group (the pump device firmly pressed three times...
Abstract Objective To investigate the distribution and influence of comminution in femoral neck fracture (FNF) patients after cannulated screw fixation (CSF). Methods From January 2019 to June 2020, a total 473 aged 23–65 years with FNF treated by CSF were included present study. Based on location cortical comminution, assigned two groups: group (anterior posterior superior inferior multiple comminutions) or without group. The incidence postoperative complications, quality life functional...
Objective: To discuss the methods, timing and clinical outcomes of surgical treatment for open pilon fractures. Methods: From April 2003 to July 2008, 28 patients with fractures were treated. All had type C according Arbeitsgemeinschaft für osteosynthesefragen–Association Study Internal Fixation (AO/ASIF) classification. Three operative methods applied, being determined by types fracture, soft tissue damage time interval after injury. Seven cases treated debridement internal fixation plate;...
BACKGROUND Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have been widely used in the treatment of non-small cell lung cancer (NSCLC) patients with sensitive EGFR mutations. However, survival EGFR-TKI administration is limited by inevitable development acquired drug resistance. Recently, multi-targeted drugs combination has shown to be a promising strategy improve efficacy and enable reduction resistance NSCLC. MATERIAL AND METHODS Humanized NSCLC lines PC9 A549...
To review the research progress of rapid surgery for hip fracture in elderly patients.
Abstract Erectile dysfunction (ED) is a male sexual with gradually increasing prevalence, and current treatments are ineffective. This study aims to find safer more effective treatment for erectile dysfunction. Bone marrow-derived mesenchymal stem cells (BM-MSCs) treated VEGFA. The expression of endothelial markers vWF, VE-cadherin eNOS were determined by overexpressing MALAT1 CDC42, respectively. results showed that interference CDC42 inhibited the differentiation BM-MSCs ECs marker-related...
<title>Abstract</title> Purpose Fermitin family member 1 (FERMT1) is associated with the progression of different types cancer. However, its biological functions FERMT1 in prostate cancer (PC) are unclear. In this study, we preliminarily investigated roles and mechanism by which it regulates PC. Methods The expression level PC tissues cells was evaluated immunohistochemical staining Western blotting (WB) assay, respectively. Celigo cell count, counting kit-8 (CCK-8), flow cytometry, wound...
Intravesical chemotherapy and immunotherapy are common adjuvant treatments for non-muscle invasive bladder cancer post-surgery. Analyzing adverse events linked to these therapies, can assist in clinical decision-making risk assessment.
Purpose: Phosphatidylinositol 3-kinase (PI3K) plays an important role in tumorigenesis by cross-talking with several signaling pathways. p55PIK is a unique regulatory subunit of PI3K and contains extra 24-residue N-terminal domain (N24). This study aimed to explore the interaction p53 regulating p53-dependent apoptosis cancer cells. Materials Methods: The expression was detected cells, examined immunoprecipitation pull-down assay. apoptosis-related genes PCR. Results: N24 interacted...
Purpose: To evaluate the therapeutic effect of teriparatide in combination with low-frequency pulsed electromagnetic field management hip fracture.Methods: Patients fracture internal fixation and under conventional postoperative basic adjuvant therapy were compared those patients who received combined low frequency after operation. The content Bone-Specific AlkalinePhosphatase (BALP), type I Procollagen Carboxy Terminal Propeptide (PICP), serum bone glaprotein (BGP), Ca2+, function degree...