A5016822007- Diabetes and associated disorders
- Systemic Lupus Erythematosus Research
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmacological Effects of Natural Compounds
- Aortic aneurysm repair treatments
- Plant Pathogenic Bacteria Studies
- Atherosclerosis and Cardiovascular Diseases
- Genetics and Neurodevelopmental Disorders
- Adipose Tissue and Metabolism
- Plant-Microbe Interactions and Immunity
- Plant Disease Resistance and Genetics
- Endoplasmic Reticulum Stress and Disease
- Genomics and Phylogenetic Studies
- Sugarcane Cultivation and Processing
- Pancreatic function and diabetes
Universidade de São Paulo
2001-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2024
There is much interest in the identification and characterization of genes involved DNA repair because their importance maintenance genome integrity. The high level conservation means that these genetic elements may be used phylogenetic studies as a source information on origin evolution species. mechanisms by which damaged repaired are well understood bacteria, yeast mammals, but remains to learned regards plants. We identified sugarcane using similarity search Brazilian Sugarcane Expressed...
Type I Diabetes mellitus (T1D) is characterized by a specific destruction of β-cells the immune system. During this process pro-inflammatory cytokines are released in pancreatic islets and contribute for demise. Cytokine-induced iNOS activation, via NF-κB, implicated induction death, which includes ER stress activation. Physical exercise has been used as an adjunct better glycemic control patients with T1D, since it able to increase glucose uptake independent insulin. Recently, was observed...
Abstract HNF4α is important for beta cells’ ability to adequately secrete insulin in response glucose concentration and endoplasmic reticulum (ER) homeostasis. In humans, mutation responsible Diabetes mellitus subtype MODY1, which has age determined onset. addition, other types of DM, there are evidences that gender can influence cell dysfunction, with possible involvement ER stress pathways. Thus, we assessed the on dysfunction induced by absence. We used an animal model specific cells KO...