A5100337471- Protein Structure and Dynamics
- Bacterial Genetics and Biotechnology
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Advanced biosensing and bioanalysis techniques
- Pelvic and Acetabular Injuries
- Geomagnetism and Paleomagnetism Studies
- Geological and Geochemical Analysis
- Inflammasome and immune disorders
- Antibiotic Resistance in Bacteria
- Systemic Lupus Erythematosus Research
- Enzyme Structure and Function
- Advanced Proteomics Techniques and Applications
- Rheumatoid Arthritis Research and Therapies
- Carbohydrate Chemistry and Synthesis
- Catalysis for Biomass Conversion
- Silymarin and Mushroom Poisoning
- Immune Cell Function and Interaction
- Vibrio bacteria research studies
- Nanoparticle-Based Drug Delivery
- Bone health and osteoporosis research
- Bacteriophages and microbial interactions
- Kidney Stones and Urolithiasis Treatments
- RNA and protein synthesis mechanisms
- Hepatitis C virus research
Southeast University
2024-2025
Tianjin University of Science and Technology
2024
Capital Normal University
2023-2024
Zhongda Hospital Southeast University
2023-2024
Harbin Medical University
2024
Third Affiliated Hospital of Harbin Medical University
2024
Chinese Academy of Geological Sciences
2023
Georgia Institute of Technology
2019-2021
Texas Tech University Health Sciences Center
2019
Texas Tech University
2019
Study Design A retrospective study. Objective To investigate the risk of adjacent segment disease (ASD) after L4-5 transforaminal lumbar interbody fusion (TLIF) in patients diagnosed with spinal stenosis (LSS), a prediction model for ASD is established and validated. Methods study was carried out on sample 290 who underwent TLIF at Zhongda Hospital, Southeast University, from January 2015 to 2021. The collected baseline data preoperative radiographic features L3-4 L5-S1. determination...
Bacterial contact-dependent growth inhibition (CDI) systems use a type Vb secretion mechanism to export large CdiA toxins across the outer membrane by dedicated transporters called CdiB. Here, we report first crystal structures of two CdiB from Acinetobacter baumannii and Escherichia coli . adopt TpsB fold, containing 16-stranded transmembrane β-barrel connected periplasmic domains. The lumen pore is occluded an N-terminal α-helix conserved extracellular loop 6; these elements different...
Abstract Pyroptosis, a newly discovered pro‐inflammatory programmed necrosis of cells, serves as an initiating and promoting event that leads to intervertebral disc (IVD) degeneration (IDD). Endoplasmic reticulum stress (ERS) autophagy are vital regulatory mechanisms cellular homeostasis, which is also closely related IDD. However, the role relationship ERS in pyroptosis nucleus pulposus cell (NPC) not well understood. In this research, we aimed elucidate mechanism ERS‐C/EBP homologous...
Enzymatic catalysis of biochemical reactions is essential to all living systems. The "lock and key" "induced fit" models were early contributions our understanding the mechanisms involved in reaction between an enzyme its substrate. However, whether a given substrate-induced conformation rigid or remains flexible has not yet been determined. By measuring activity intrinsic fluorescence nonspecific <i>Eisenia fetida</i> protease-I with different chromogenic substrates, we show that subsequent...
Peripheral T-cell lymphoma (PTCL) is a highly aggressive type of non-Hodgkin's with poor prognosis. Pyroptosis newly discovered procedural cell death mode, which has been implicated to occur in both tumor cells and immune cells. However, the occurrence effect pyroptosis on PTCL remain unclear. Here, we found that occurred interstitial macrophages rather than In clinical specimens, macrophage was associated prognosis PTCL. vitro experiments gene sequencing results showed pyroptotic could...
Abstract Crustal deformation and hydrothermal percolation related to the India‐Asia collision have caused extensive remagnetization of Tethyan Himalaya Terrane (THT). The present work identified three phases regional during 62.3–50.0 Ma for east‐central THT. Consequently, a model three‐stage was proposed. THT first collided with southward migrated southern margin Lhasa (LT) at 5.4 ± 0.9°N 62.3–60.9 Ma. Subsequently, continuously moved northward pushed LT back its original position prior...
Convenient methods for the preparation of gene delivery platforms based on branched low molecular weight polyethylenimine (PEI) were described. Firstly, PEI lipids, with a headgroup and hexadecyl chain tail group, prepared through highly efficient ring-opening reaction glycidyl ether (EpoxyC16) by amine from PEI. Then, lipids used as component cationic liposomes surfactant poly(D,L-lactide-co-glycolide) (PLGA) nanoparticle (NP) via solvent extraction/evaporation method. As potential...
Co-immobilization of enzymes used in cascade reactions is important for improving the overall catalytic efficiency. In this work, we employed scaffoldins as a bridge and succeeded highly-ordered co-localization multiple proteins on magnetic nanoparticles with loading capacity ∼0.831 μmol g−1 supports.
To illustrate the effect of geniposide (GP) and panax notoginseng saponins (PNS) on estrogen receptors (ER) including ERα ERβ within cytoplasm nucleus SH-SY5Y cells. Immunofluorescence was used to observe distribution in nucleus, but Western blot only for detection. q-PCR applied detect NR3C1, S100A6 LGALS1downstream mRNA gene expression levels ER. Through analyzing fluorescence intensity under administration GP PNS cells, we found that has not been affected. We also discovered and/or...
Abstract Growth strata are important for understanding regional tectonic evolution. However, it is difficult to identify growth in the field, because of subsequent intensive modification and erosion. To address this problem, we studied two paleomagnetic sections at stable deposition setting end Miocene Gengma Basin. Average inclinations show a systematic deviation 4.7° ± 5.2°. The anisotropy magnetic susceptibility results section A demonstrate sedimentary fabric. tilt‐corrected K 3 axis...