A5100698890- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Plant Virus Research Studies
- Ruminant Nutrition and Digestive Physiology
- Probiotics and Fermented Foods
- Herpesvirus Infections and Treatments
- Genetic Associations and Epidemiology
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
- Phytoestrogen effects and research
- Virus-based gene therapy research
- Animal Nutrition and Physiology
- Nuclear Receptors and Signaling
- Nerve injury and regeneration
- Viral-associated cancers and disorders
- Genomics, phytochemicals, and oxidative stress
- Chronic Lymphocytic Leukemia Research
- Autophagy in Disease and Therapy
- Polysaccharides and Plant Cell Walls
- Lymphoma Diagnosis and Treatment
- Advanced DC-DC Converters
- Aquaculture Nutrition and Growth
- Agroforestry and silvopastoral systems
- Microbial Community Ecology and Physiology
- Heavy Metal Exposure and Toxicity
Tianjin Agricultural University
2021-2024
China Agricultural University
2010-2024
Huazhong Agricultural University
2020-2024
Ludong University
2024
University of Nevada, Las Vegas
2023
Yale University
2023
Tangshan Gongren Hospital
2016-2017
Second Xiangya Hospital of Central South University
2016
Central South University
2016
The University of Texas Health Science Center at Houston
2016
Some coronaviruses (CoVs) have an extra furin cleavage site (RRKR/S, furin-S2′ site) upstream of the fusion peptide in spike protein, which plays roles virion adsorption and fusion. Mutation S2′ QX genotype (QX-type) infectious bronchitis virus (IBV) protein (S) a recombinant background results higher pathogenicity, pronounced neural symptoms neurotropism when compared with conditions wild-type IBV (WT-IBV) infected chickens. In this study, we present evidence suggesting that mutant...
Zinc oxide nanoparticles (ZnO NPs) with high bioavailability and excellent physicochemical properties are gradually becoming commonplace as a substitute for conventional ZnO materials. The present study aimed to investigate the hepatotoxicity mechanism of NPs traditional non-nano particles, both in vivo vitro, identify differences their toxic effects. results showed that extent conditions zinc ion release from were inconsistent those ZnO. RNA-seq revealed expression quantity differentially...
Background/Aims: To explore the effects of sulforaphane (SFN) on neuronal apoptosis in hippocampus and memory impairment diabetic rats. Methods: Thirty male rats were randomly divided into normal control, model SFN treatment groups (N = 10 each group). Streptozotocin (STZ) was applied to establish model. Water Morris maze task test learning memory. Tunel assaying used detect hippocampus. The expressions Caspase-3 myeloid cell leukemia 1(MCL-1) detected by western blotting. Neurotrophic...
Infectious bronchitis is a severe disease caused by infectious virus (IBV) that affects fowl flocks worldwide. The understanding of the mechanisms involved in IBV evolution and variation would provide important theoretical basis for prevention control future.IBV strain GD was isolated from southern China 2013 complete genome sequencing phylogenetic analysis were performed.The approximately 27,680 nt comprised six genes, with insertions mutations most structural genes. S1 gene showed highest...
Heat shock 70-kDa protein 5 (Hspa5), also known as binding immunoglobulin (Bip) or glucose-regulated 78 (Grp78), belongs to the heat 70 kDa family. As a multifunctional protein, it participates in folding and calcium homeostasis serves an essential regulator of endoplasmic reticulum (ER) stress response. It has been implicated signal transduction by acting receptor co-receptor residing at plasma membrane. Its function during embryonic development, however, remains largely elusive. In this...
Toll-like receptors (TLR) are trans-membrane sensors recognizing invading microbes. play a central role in initiating immune responses against several pathogens. In this study, we investigated the response of TLR and downstream genes to Marek's disease virus (MDV) infection. Forty 1-d-old chicks were randomly divided into 2 groups, with 20 infected MDV mock-infected. Four chickens euthanized respectively from age-matched noninfected groups at 4, 7, 14, 21, 28 d postinfection (dpi). Bursas,...
Avian infectious bronchitis, a highly contagious disease caused by avian bronchitis virus (IBV), is of considerable economic importance to the poultry industry. New IBV TW-like strains have increasingly emerged in China recent years; hence, evaluating their pathogenicity and developing specific vaccine guard against potential threat industry important. Here, we examined strain (GD), evaluated protective efficacy QX-like (JS) GD challenge infections chickens. The results revealed that...
Major histocompatibility complex has previously been shown to influence the resistance of chicken Marek’s disease virus (MDV). However, little is known about expression other genes in MHC-I and II pathway after MDV infection. This study aimed at investigating 8 immune-related MHC core region that affects host responses MDV. Spleens infected age-matched uninfected chickens were removed 4, 7, 14, 21, 28 d postinfection for gene detection using real-time PCR. Different patterns observed spleen....
Type 2 diabetes (T2DM) is associated with cognitive deficits. However, their pathophysiological mechanisms are still unknown. Recent study suggests that brain-derived neurotrophic factor (BDNF) correlated deficits in T2DM patients. This was to determine whether altered serum BDNF levels and depended on the Val66Met polymorphism T2DM.The may not contribute directly susceptibility T2DM. The total nearly all index scores (all p < 0.01) except for attention visuospatial/constructional indexes...
In Asia, young-onset type 2 diabetes (YOD) is characterized by obesity and increased risk for cardiovascular disease (CVD). a genome-wide association study (GWAS) of 99 Chinese obese subjects with familial YOD diagnosed before 40-year-old 101 controls, the T allele rs1408888 in intron 1 DACH1(Dachshund homolog 1) was associated an odds ratio (OR) 2.49(95% confidence intervals:1.57–3.96, P = 8.4×10−5). Amongst these subjects, we found reduced expression DACH1 peripheral blood mononuclear...
Abstract Background The inefficient utilization of plant residues leads to serious environmental pollution and loss nutrition. Nevertheless, the herbal including valuable mugwort have been rarely explored. Ensiling has considered as a promising technique reuse residues. Thus, this study investigated effect (M) Lactiplantibacillus pentosus (LAB) on fermentation quality, bacterial diversity, metabolites alfalfa silage after 60 days ensiling. Results results showed that compared with control,...
Abstract Background Paper mulberry has been considered as a high-quality protein feedstuff to cope with the shortage of feed and development livestock. In addition, features high moisture low water-soluble carbohydrate concentration in fresh paper make it difficult ensile. Therefore, is important find an optimal way improve silage quality. this study, we aimed investigate application Lactobacillus plantarum (LP) wheat bran (WB) on fermentation characteristics, chemical composition microbial...