A5100308731- Autoimmune and Inflammatory Disorders
- Cancer Research and Treatments
- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- Inflammasome and immune disorders
- Poxvirus research and outbreaks
- Toxin Mechanisms and Immunotoxins
- Cancer Immunotherapy and Biomarkers
- Bacillus and Francisella bacterial research
- CRISPR and Genetic Engineering
- Health disparities and outcomes
- Plant Virus Research Studies
- Galectins and Cancer Biology
- IL-33, ST2, and ILC Pathways
- Liver Disease Diagnosis and Treatment
- Demographic Trends and Gender Preferences
- interferon and immune responses
- scientometrics and bibliometrics research
- Herpesvirus Infections and Treatments
- Intergenerational Family Dynamics and Caregiving
- Atmospheric and Environmental Gas Dynamics
- Geochemistry and Geochronology of Asian Mineral Deposits
- Statistics Education and Methodologies
- Celiac Disease Research and Management
- MRI in cancer diagnosis
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Zhongnan Hospital of Wuhan University
2024
Anhui Normal University
2024
Yangtze Optical Electronic (China)
2024
Guangdong Medical College
2024
Wuhan University
2024
Princeton University
2017-2023
Sichuan University
2023
West China Hospital of Sichuan University
2023
Shanghai Jiao Tong University
2023
"We propose to change the default P-value threshold forstatistical significance for claims of new discoveries from 0.05 0.005."
Mpox is caused by a zoonotic virus belonging to the Orthopoxvirus genus and Poxviridae family. In this study, we develop recombinase polymerase amplification (RPA)-coupled CRISPR-Cas12a detection assay for mpox virus. We design test series of CRISPR-derived RNAs(crRNAs) targeting conserved D6R E9L genes orthopoxvirus unique N3R N4R viruses. crRNA-1 exhibits most robust activity in detecting orthopoxviruses, crRNA-2 able distinguish from other orthopoxviruses. The Cas12a/crRNA alone presents limit 10
To investigate the influence of sports participation on life satisfaction internal migrants and its mechanism. A total 579 valid samples were obtained from 2017 Chinese General Social Survey data. The correlations among physical exercise, watching games (live), social interaction, self-efficacy, examined using Pearson correlation analyses. chain mediating model was tested utilizing PROCESS macro for IBM SPSS Statistics. (a) Two forms participation, exercise are shown to impact in China,...
Since May 2022, the multi-country outbreak of monkeypox (mpox) has raised a great concern worldwide. Early detection mpox virus infection is recognized as an efficient way to prevent transmission. Mpox specific methods reported up now are based on SNPs among and other orthopoxviruses. We have therefore developed real-time PCR method targeting sequences (N3R B18Rplus). also optimized orthopoxvirus system which targets highly conserved E9L D6R genes. The assays high sensitivity (1...
Abstract The mpox outbreak has subdued with fewer reported cases at the present in high‐income countries. It is known that virus (MPXV) infection been epidemic for more than 50 years African ancestral MPXV strain changed into multiple clades, indicating ongoing evolution of MPXV, which reflects historical neglect Africa, especially after smallpox eradication, and bestows danger severe epidemics future. thus imperative to continue development diagnostics treatments so we can be prepared event...
Cytokines play vital roles in the pathogenesis of inflammatory bowel disease. IL17B is protective development colitis. However, how regulates intestinal inflammation and what cells are regulated by still unknown. Here, we aimed to illustrate dependent cellular molecular changes colon tissue a mouse colitis model. The results showed that expression tissues was elevated inflamed than non-inflamed IBD patients. Wild type (WT) Il17b deficient (Il17b -/-) mice were given 2.5% dextran sodium...
Standard magnetic resonance imaging (MRI) techniques are different to distinguish minimal fat angiomyolipoma (mf-AML) with from renal cell carcinoma (RCC). Here we aimed evaluate the diagnostic performance of MRI-based radiomics in differentiation fat-poor AMLs other neoplasms.A total 69 patients solid tumors without macroscopic and a pathologic diagnosis RCC (n=50) or mf-AML (n=19) who underwent conventional MRI intravoxel incoherent motion diffusion-weighted (IVIM-DWI) were included....
Background: Parkinson's disease is the second major neurodegenerative diseases secondarily to Alzheimer's disease. Rapamycin a fermentation product, which derived from Streptomyces hygroscopius. The aim of this study investigate effect rapamycin and its potential mechanisms on acute attack 1-methyl-4-phenyl-1,2,3,6-four hydrogen pyridine (MPTP) induced (PD) in mice.Methods: PD model was established by intraperitoneal injection MPTP for 5 days. treating symptoms caused evaluated behavior...
Background: Severe lethal allergic reactions triggered by iodixanol following digital subtraction angiography (DSA) are rare. The majority of skin associated with were mild, and the prognosis was favorable. Moreover, a case serious adverse events caused has been documented. Methods: A 61-year-old woman underwent surgery for cerebral hemorrhage in another hospital. Upon surgery, patient’s state impaired consciousness did not show any improvement. Head computed tomography on admission: right...
The clinical outcome of intracranial infections caused by extensively drug-resistant Acinetobacter baumannii (XDRAB) remains unsatisfactory, even when treated with combined antibiotic therapy. This study successfully cured 1 patient XDRAB infection after cranial surgery through a multichannel combination drugs, providing reference for the treatment severe infection.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines provide essential tools for the control of COVID-19 pandemic. A number technologies have been employed to develop SARS-CoV-2 vaccines, including inactivated particles, mRNA express viral spike protein, recombinant proteins, and vectors. Here, we report use vaccinia virus Tiantan strain as a vector protein. When it was used inoculate mice, robust protein-specific antibody response T-cell were detected. Sera from vaccinated...
Monkeypox (mpox) outbreak in 2022 has caused more than 91 thousand cases, spread to 115 countries, regions and territories, thus attracted much attention. The stability of poxvirus particles the environment is recognized as an important factor determining their transmission. However, few studies have investigated persistence poxviruses on material surfaces under various environmental conditions, sensitivity biocides. Here, we systematically measured vaccinia virus different conditions...
To investigate the clinical practicability of positive end-expiratory pressure (PEEP) titrated by lung stretch index (SI) in patients with acute respiratory distress syndrome (ARDS).
Although numerous studies have shown that bariatric surgery results in sustained weight loss and modifications gut microbiota composition cognitive function, the exact underlying mechanisms are unclear. This study aimed to investigate effects of on function through microbiota-gut-brain axis (MGBA).