A5103209755- Liver Disease Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Systemic Lupus Erythematosus Research
- Animal Virus Infections Studies
- Renal Diseases and Glomerulopathies
- Inflammasome and immune disorders
- Dialysis and Renal Disease Management
- Medical Research and Treatments
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- RNA modifications and cancer
- Cardiovascular Syncope and Autonomic Disorders
- SARS-CoV-2 and COVID-19 Research
- Celiac Disease Research and Management
- Autoimmune and Inflammatory Disorders Research
- Respiratory viral infections research
- Aquatic Ecosystems and Phytoplankton Dynamics
- COVID-19 and Mental Health
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced biosensing and bioanalysis techniques
- T-cell and B-cell Immunology
- CRISPR and Genetic Engineering
- Viral-associated cancers and disorders
- Immune cells in cancer
- Water Quality and Pollution Assessment
Huazhong University of Science and Technology
2020-2025
Ruijin Hospital
2024
Tongji Hospital
2023
Southern Medical University
2023
Chinese Research Academy of Environmental Sciences
2022
Central Hospital of Wuhan
2021
Second Military Medical University
2018
Changhai Hospital
2018
The Affiliated Yongchuan Hospital of Chongqing Medical University
2015-2016
Chongqing Medical University
2015-2016
Abstract Interleukin-1 (IL-1) and the IL-1 receptor (IL-1R) family play an important role in pathogenesis of inflammatory diseases. This study aimed to investigate association between single nucleotide polymorphisms (SNP) IL-1R genes with Vogt-Koyanagi-Harada (VKH) Behcet’s disease (BD) Han Chinese. The case-control was divided into two stages included 419 VKH cases, 1063 BD cases 1872 healthy controls. MassARRAY platform (Sequenom), iPLEX Gold Assay TaqMan SNP assays were used score...
Abstract Improving the level of arteriovenous fistula (AVF) self‐care behavior by people receiving hemodialysis is an effective way to reduce occurrence complications and mortality. The aim this study was assess Chinese patients undergoing with fistula. assessment behaviors in (ASBHD‐AVF, Portuguese version) translated into using Brislin's translation model. content validity evaluated six experts. Then we involved 301 AVF explore construct version ASBHD‐AVF. Ultimately 216 from eight...
Abstract The CRISPR–Cas12a system is widely used in nucleic acid detection and biosensing due to its high sensitivity, selectivity, simple design. However, traditional sensors, which rely on linear activators, face challenges such as limited operability low stability. This study explored the impact of three different activator topologies—linear, planar, steric—on trans-cleavage activity Cas12a. We developed a Cas12a-based switch using planar activator, demonstrated superior maintained higher...
Abstract This study investigated the genetic polymorphisms of HLA‐B27 , together with on endoplasmic reticulum aminopeptidase 1 ( ERAP1 ), and susceptibility for ankylosing spondylitis AS ) in Beijing Han population. A case‐control was carried out 602 patient samples 619 matched controls Chinese. genotyping performed by polymerase chain reaction‐sequence specific primers PCR‐SSP four SNPs (rs27037, rs27980, rs27582, rs27434) were selected genotyped Sequenom iPlex platform (Sequenom, San...
Reducing phosphorus input is currently the main lake eutrophication management strategy, but algal blooms persist in many lakes despite effective abatement measures. This study analyzed monitoring data across 70 Chinese using statistical methods to reveal spatiotemporal characteristics of algae production efficiency total (ETP) and driving factors ETP changes. The results showed that ranged from 0.01 1.87 2016 2018. Spatially, with higher values were concentrated Yungui Plateau region due...
Although the association between mouth ulcers and psychiatric traits has been reported by observational studies, their causal relationship remains unclear. Mendelian randomization (MR), powered large-scale genome-wide studies (GWAS), provides an opportunity to clarify causality traits. We collected summary statistics of (sample size n = 461,106) 10 from largest publicly available GWAS on Europeans, including anxiety disorder (n 83,566), attention deficit/hyperactivity 53,293), autism...
Whole-exome sequencing (WES) has been widely used to study the role of protein-coding variants in genetic diseases. Non-coding regions, typically covered by sparse off-target data, are often discarded conventional WES analyses. Here, we develop a genotype calling pipeline named WEScall analyse both target and data. We leverage linkage disequilibrium shared within samples from an external reference panel improve genotyping accuracy. In application 2527 Chinese Malays, can reduce discordance...
The pandemic of Coronavirus disease 2019 (COVID-19) has posed an enormous threat to human health. According observational studies, abnormal liver and kidney functions blood cell traits were associated with severe COVID-19, yet the causal risk factors for COVID-19 severity underlying mechanism remained elusive. We performed Mendelian randomization analyses assess potential role eight function biomarkers, one biomarker, 14 hematological on using genetic association summary statistics from...
Abstract Background There is a correlation between nutritional status and treatment outcomes long-term survival in MHD patients but there limited research on the relationship GNRI IDH. This case-control study aimed to investigate Geriatric Nutritional Risk Index (GNRI) intradialytic hypotension (IDH) elderly undergoing maintenance hemodialysis (MHD). Methods was carried out 129 cases of with IDH 258 non-IDH-controls Ruijin Hospital, Shanghai Jiaotong University School Medicine, China, June...
Abstract Background Aedes albopictus is an invasive vector of serious -borne diseases global concern. Habitat management remains a critical factor for establishing cost-effective systematic strategy sustainable control. However, the community-based characteristics Ae. habitats in complex urbanization ecosystems are still not well understood. Methods A large-scale investigation aquatic habitats, involving 12 sites selected as representative four land use categories at three levels, was...
Abstract Background Although immune cells are involved in acute coronary syndrome (ACS), few studies have explored the association of incident ACS with relative cell proportions. We aimed to investigate proportions incidence and risk factors Dongfeng–Tongji cohort. Methods conducted analyses 38,295 subjects from first follow-up cohort, including DNA methylation profiles for 1570 individuals. The types were observed routine blood tests or estimated profiles. For both proportions, we tested...
Exploring whether medical staff perceive stress on the assigned tasks, what are specific sources of stress, tangible support they expected to be helpful, and individual coping with provide more accurate, personal for psychological crisis. This study uses a cross-sectional descriptive survey adopting convenience sampling among who worked over seven days in infected areas one Grade 2A three 3A hospitals during COVID-19 pandemic. The assessment includes attitude when receiving major stressors,...
Abstract Background Previous studies have demonstrated that natural killer (NK) cells migrated into the liver from peripheral organs and exerted cytotoxic effects on hepatocytes in virus-induced failure. Aim This study aimed to investigate potential therapeutic role of chemokine receptors migration NK a murine hepatitis virus strain 3 (MHV-3)-induced fulminant hepatic failure (MHV-3-FHF) model its mechanism. Results By gene array analysis, (C–C motif) receptor 5 (CCR5) was found remarkably...
Background: The association between mouth ulcers and psychiatric traits has been reported by observational studies. However, their causal relationship remains unclear. Methods: We collected summary statistics of ten from the largest publicly available genome-wide studies (GWAS) on Europeans, including anxiety disorder (sample size n=83,566), attention deficit/hyperactivity (n=53,293), autism spectrum (n=46,350), bipolar (n=51,710), insomnia (n=1,331,010), major depressive (n=480,359), mood...