A5003665260- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- Ferroptosis and cancer prognosis
- Breast Lesions and Carcinomas
- MicroRNA in disease regulation
- Endometrial and Cervical Cancer Treatments
- Breast Implant and Reconstruction
- Circular RNAs in diseases
- Advanced Radiotherapy Techniques
- Heme Oxygenase-1 and Carbon Monoxide
- Cervical Cancer and HPV Research
- Cancer Risks and Factors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- BRCA gene mutations in cancer
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
Weifang People's Hospital
2008-2025
Qilu Hospital of Shandong University
2021-2023
Pyroptosis and inflammation are involved in the development of chronic obstructive pulmonary disease (COPD). However, cigarette smoke-mediated mechanism COPD remains unclear. In this study, we aimed to investigate role nucleotide-binding domain-like receptor protein-3 (NLRP3) inflammasome-mediated pyroptosis death human bronchial epithelial (HBE) cells after smoke extract (CSE) exposure.The protein level NLRP3 lung tissue was measured exposure vivo. vitro, HBE were treated with CSE....
Background Survival prediction for cervical cancer is usually based on its stage at diagnosis or a multivariate nomogram. However, few studies cared whether long-term survival improved after they survived several years. Meanwhile, traditional analysis could not calculate this dynamic outcome. We aimed to assess the improvement of over time using conditional (CS) and developed novel nomogram (CS-nomogram) provide individualized real-time prognostic information. Methods Cervical patients were...
Lung adenocarcinoma (LUAD) has become the main histologic type, which account for nearly 40% of lung cancer.The present study aimed to investigate gene expression signature in smoking related LUAD.A total 45 DEGs LUAD were identified and functional enrichment analysis was also performed.Then Cox's regression model Kaplan-Meier used screen potential prognostic genes.Finally, AURKA FAM83A left further immune-related mechanism exploration.Kaplan-Meier indicated survival rates are different...
Gamma ray can promote cancer cell apoptosis and cycle arrest. It is often used in the clinical treatment of tumors, including lung cancer. In this study, we aimed to explore role gamma its correlation with BTG2 proliferation, apoptosis, arrest regulation a line. A549 viability, rate, were investigated after treatment. We then siRNA for detect effect knockdown on progress ray-treated cells. Finally, signaling pathway by which might regulate BTG2. found that inhibited viability promoted...
Autophagy plays an important role in non-small cell lung cancer (NSCLC). We aimed to establish novel autophagy-related tumor subtypes distinguish the prognosis of NSCLC. In this study, gene expression profiles, mutation data and clinical information obtained from Cancer Genome Atlas. Kaplan Meier-plotter could evaluate prognostic value genes. Consensus clustering revealed subtypes. Gene immune infiltration signatures were identified, oncogenic pathways gene-drug interactions performed...
Acute lung injury (ALI) is a fatal syndrome frequently induced by lipopolysaccharide (LPS) released from the bacterial cell wall. LPS could also trigger autophagy of bronchial epithelial to relieve inflammation, while overwhelming would impair balance consequently inducing serious injury.We observed variation 16HBE, human cell, under exposure different concentrations through western blot, immunofluorescence staining, and electron microscopy. Eight strands 16HBE were divided into two groups...
Radiotherapy is the primary method in treating advanced cervical cancer.Intensity-modulated radiation therapy(IMRT)has advantage of individualized planning,safe and rational dose distribution.It can improve curative effect,reduce organs at risk(OAR),decrease complication.So IMRT will play an important role management cancer. Key words: Cervix neoplasms; Radiotherapy; Intensity-modulated therapy