A5042071594- Hepatitis C virus research
- Drug-Induced Adverse Reactions
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Vaccine Coverage and Hesitancy
- Global Maternal and Child Health
- COVID-19 epidemiological studies
- Asthma and respiratory diseases
- Pharmaceutical studies and practices
- Healthcare Systems and Reforms
- Disaster Response and Management
- COVID-19 Pandemic Impacts
- Hematopoietic Stem Cell Transplantation
- Child Nutrition and Water Access
- Numerical methods for differential equations
- Neutropenia and Cancer Infections
- Food Allergy and Anaphylaxis Research
- Complement system in diseases
- Nonlinear Photonic Systems
- Viral Infections and Outbreaks Research
- COVID-19 Digital Contact Tracing
- Allergic Rhinitis and Sensitization
- Proteoglycans and glycosaminoglycans research
- Melanoma and MAPK Pathways
- Birth, Development, and Health
Stanford Medicine
2012-2025
Stanford University
2012-2024
National Cancer Institute
2022-2024
Center for Cancer Research
2024
BIO Ventures for Global Health
2023-2024
Gates (United States)
2022-2023
University of Washington
1959-2023
National Institutes of Health
2022
Harvard University
2016-2020
Brigham and Women's Hospital
2016-2020
Abstract Community health worker programs have emerged as one of the most effective strategies to address human resources for shortages while improving access and quality primary healthcare. Many developing countries succeeded in deploying community recognition potential workers identify, refer, many cases treat illnesses at household level. However, challenges program design sustainability are expanded when such scale, particularly with regard systems management integration facilities....
Challenges in data availability and quality have contributed to the longest deadliest Ebola epidemic history that began December 2013. Accurate surveillance data, particular, has been difficult access, as it is often collected remote communities. We describe design, implementation, challenges of implementing a smartphone-based contact tracing system linked analytics visualization software part response Guinea. The system, built on mobile application CommCare business intelligence Tableau,...
To provide cost guidance for developing a locally adaptable and nationally scalable community health worker (CHW) system within primary-health-care systems in sub-Saharan Africa.The yearly costs of training, equipping deploying CHWs throughout rural Africa were calculated using data from the literature Millennium Villages Project. Model assumptions such as to allow national governments adapt CHW subsystem needs deploy an average 1 per 650 inhabitants by 2015. The described was costed...
The 2013-2016 Ebola virus disease outbreak in West Africa exposed an urgent need to strengthen health surveillance and systems low-income countries, not only improve the of populations served by these but also promote global security. (1) Chronically fragile under-resourced (2) enabled initial Guinea spiral into epidemic over 28 616 cases 11310 deaths (as 5 May 2016) (3) Guinea, Liberia Sierra Leone, requiring unprecedented response that is still ongoing. Control efforts were hindered gaps...
Abstract Introduction As part of efforts to rapidly identify and care for individuals with COVID-19, trace quarantine contacts, monitor disease trends over time, most African countries implemented interventions strengthen their existing surveillance systems. This research describes the strengths, weaknesses lessons learnt from COVID-19 strategies in four inform enhancement systems future epidemics on continent. Methods The namely Democratic Republic Congo (DRC), Nigeria, Senegal, Uganda,...
The FilmArray meningitis/encephalitis (ME) panel is a novel syndromic, nucleic acid amplification test for diagnosis of acute meningitis and encephalitis. Emerging data on its performance are concerning false-positive results. We present case tuberculous misdiagnosed as herpes simplex virus-1 encephalitis with the ME panel. Strategies to mitigate erroneous results discussed.
Data on liver and non-liver co-morbidities in chronic hepatitis B (CHB) patients are limited. This study analyzes the prevalence of a multicenter CHB cohort evaluated over 15 years.This included 2734 consecutive adult American from university medical center several community primary care clinics. were analyzed by time periods (patients each period unique without overlapping): 2000-2005 (n = 885), 2006-2010 888), 2011-2015 961). Patients identified via electronic query using diagnosis code...
Abstract Background The COVID-19 pandemic control strategies disrupted the smooth delivery of essential health services (EHS) globally. Limited evidence exists on systems lens approach to analyzing challenges encountered in maintaining EHS during pandemic. This study aimed identify system and document mitigation adaptations made across geopolitical zones (GPZs) Nigeria. Methods national qualitative survey key actors six GPZs Nigeria involved ten states Federal Capital Territory (FCT) which...
Treatment end-point of therapy for patients with hepatitis B e antigen (HBeAg)-positive chronic (CHB) includes HBeAg seroconversion, which ranges from 15% to 22% after 1 year oral nucleos(t)ides according clinical trials. Our goal was determine the incidence and predictors seroconversion in such routine practice because they may differ than reported rates.We conducted a retrospective cohort study 333 consecutive treatment-naïve HBeAg-positive who were treated CHB between 1/2000 6/2010 at...
Data from registration trials with highly selective patients have shown that hepatitis B envelope antigen (HBeAg)-positive chronic respond well to entecavir (ETV) 0.5 mg daily, an HBeAg seroconversion rate of 21% at 12 months. However, there are varying data on the treatment outcomes ETV daily in routine clinical settings, rates months ranging 8 48% studies limited 44-90 centers Asia, Europe, and South America.In present study, we examined long-term efficacy tolerability 136 consecutive...
We describe the case of a 44-year-old female patient on rituximab for treatment multiple sclerosis with undetectable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG specific antibodies 18 days after second dose SARS-CoV-2 vaccine. Interferon-gamma release assay testing was positive day 19, demonstrating robust T cell-mediated response despite lack an antibody-mediated response.
Introduction The SARS-CoV-2 (COVID-19) pandemic overwhelmed some primary health care (PHC) systems, while others adapted and recovered. In Nigeria, large, within-state variations existed in the ability to maintain PHC service volumes. Identifying characteristics of high-performing local government areas (LGAs) can improve understanding subnational systems resilience. Methods Employing a sequential explanatory mixed-methods design, we quantitatively identified ‘positive deviant’ LGAs based on...
Background The COVID-19 pandemic has led to substantial interruptions in critical health services, with 90% of countries reporting routine vaccinations, maternal care and chronic disease management. use non-pharmaceutical interventions (NPIs) such as lockdowns self-isolation had implications on the provision essential services (EHS). We investigated exemplary outbreak control strategies explored extent which adoption these NPIs affected EHS including immunization coverage facility-based...
Chronic hepatitis B (CHB) can progress to cirrhosis, but there are limited noninvasive tools available estimate cirrhosis risk, including in patients receiving antiviral therapy. This study developed and validated a simple model assess risk CHB patients.The derivation cohort included 3000 from 6 centers the United States, with 52.60% External validation was performed for 4552 individuals similar cohorts Taiwan, 21.27% Cox proportional hazards regression analyses were used screen predictors...