A5083342342- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Obstructive Sleep Apnea Research
- Diabetes Treatment and Management
- Cardiac Arrhythmias and Treatments
- Pancreatic function and diabetes
- Diet and metabolism studies
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- Cardiovascular Health and Disease Prevention
- Cardiac Structural Anomalies and Repair
- Spaceflight effects on biology
- Adrenal and Paraganglionic Tumors
- Colorectal Cancer Surgical Treatments
- Cardiomyopathy and Myosin Studies
- Sodium Intake and Health
- Congenital Anomalies and Fetal Surgery
- Intestinal and Peritoneal Adhesions
- Food Industry and Aquatic Biology
- Traditional Chinese Medicine Studies
- Parasitic infections in humans and animals
- Cardiovascular and Diving-Related Complications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Appendicitis Diagnosis and Management
Queen Giovanna Hospital
2011-2025
Medical University of Sofia
2024-2025
Parallax Research (United States)
2021
<h3>Importance</h3> There is limited evidence on the benefits of sacubitril/valsartan vs broader renin angiotensin system inhibitor background therapy surrogate outcome markers, 6-minute walk distance, and quality life in patients with heart failure mildly reduced or preserved left ventricular ejection fraction (LVEF >40%). <h3>Objective</h3> To evaluate effect N-terminal pro–brain natriuretic peptide (NT-proBNP) levels, medication–based individualized comparators chronic LVEF more than...
OBJECTIVE To determine whether the benefits of dapagliflozin in patients with heart failure and reduced ejection fraction (HFrEF) type 2 diabetes Dapagliflozin And Prevention Adverse-Outcomes Heart Failure trial (DAPA-HF) varied by background glucose-lowering therapy (GLT). RESEARCH DESIGN AND METHODS We examined effect study treatment use or not GLT classes combinations. The primary outcome was a composite worsening (hospitalization urgent visit requiring intravenous therapy) cardiovascular...
Abstract Background: Trimethylamine N-oxide (TMAO) is synthesized by the intestinal microbiota and an independent predictor of cardiovascular disease (CVD). However, its underlying mechanisms remain unclear. We investigated TMAO levels across different CVD-risk patient groups, evaluated associations between vascular alterations (e.g., arterial stiffness, intima-media thickness [IMT], presence grade carotid artery plaques [CAPs]). Methods: examined 95 patients (58.5 ± 7.3 years): 40 with...
Background: Acute decompensated heart failure (ADHF) is a condition with high frequency of hospitalizations and mortality, obstructive sleep apnea (OSA) common comorbidity. Continuous positive airway pressure (CPAP) therapy at home can be good adjunctive non-drug for these patients. Methods: We conducted single-center, prospective cohort study from 150 consecutive patients hospitalized exacerbation in the cardiology department. Of these, 57 had apnea. After discharge, CPAP was offered....
Background: Managing acute decompensated heart failure (ADHF) is complex, particularly when combined with comorbidities like sleep apnea. Effective treatment requires personalized approaches, focusing on quality of life (QoL) and mental health outcomes. Purpose: This study explored the prevalence characteristics apnea in patients obesity AHF exacerbations. It assessed how different phenotypes impact QoL health, applying medicine strategies. Methods: A prospective cohort was conducted 150...
Sodium glucose cotransporter 2 inhibitors reduce morbidity and mortality in patients with heart failure reduced ejection fraction (HFrEF). Clinicians may find estimates of the projected long-term benefits sodium a helpful addition to clinical trial results when communicating this class drug patients.To estimate treatment effects dapagliflozin HFrEF over duration patient's lifetime.Exploratory analysis was performed Dapagliflozin Prevention Adverse Outcomes Heart Failure (DAPA-HF), phase 3...
Trimethylamine-N-oxide (TMAO) is a metabolite produced by intestinal microbiota. It well recognized as an independent risk marker for cardiovascular and renal diseases mortality.
Left ventricular (LV) twist serves as a compensatory mechanism in systolic dysfunction and its degree of reduction may reflect more advanced stage disease.The aim was to investigate alterations depending on the functional mitral regurgitation (MR) by speckle-tracking echocardiography.Sixty-three patients with symptomatic dilated cardiomyopathy (DCM) were included. Patients divided according MR vena contracta width (VCW): group 1 VCW <7 mm (mild/moderate MR) 2 ≥7 (severe MR).There no...
Imbalance of activation and inhibition matrix metalloproteinases (MMPs) lead to an increase in their activity the occurrence pathological changes vascular wall. The purpose this paper is determine role MMP-2 MMP-9 ventricular remodelling patients with heart failure preserved ejection fraction. were divided into three groups: 15 fraction (HFpEF), 72.73 ± 10.44 years old; arterial hypertension (AH), 63.73±7.06 10 healthy controls, 58.7± 5.87 old. Arterial stiffness was assessed by pulse wave...
Transthyretin amyloidosis (ATTR) is a systemic disease characterized by the deposition of amyloid &#64257; brils in various tissues, leading to progressive neurological manifestations and development cardiomyopathy, necessitating timely diagnosis treatment. This article presents clinical case 74-year-old patient with hereditary transthyretin (ATTRv), diagnosed using non-invasive imaging methods &ndash; echocardiography, magnetic resonance imaging, single-photon emission computed...
Background: Acute decompensated heart failure (ADHF) is often associated with central sleep apnea (CSA), which exacerbates cardiovascular strain and impacts quality of life. In ADHF patients, CSA contributes to recurrent nocturnal oxygen desaturation, elevated apnea-hypopnea index (AHI), frequent Cheyne-Stokes respiration episodes, increasing health risks. Echocardiographic monitoring essential in these providing reliable assessment function over time. Sodium-glucose cotransporter-2...
Background: The prevalence of obesity and hypertension among healthcare professionals has been previously described. Both diseases are known risk factors for atrial cardiomyopathy (ACM), a new clinical entity with potential to be determinant heart failure, &#64257; brillation thromboembolic complications. In this perspective, early preventive strategy should initiated in special population. Aim: To de&#64257; ne ACM middle-aged women professionals. Material methods: Hundred ve...
Abstract Funding Acknowledgements Type of funding sources: None. Background Atrial fibrillation (AF) is a progressive disease and can initiates maintains in the absence left atrial (LA) enlargement¹´². Echocardiographic parameters LA mechanics had been proposed for best dealing with patients AF³ . Combining different laboratory biomarkers echocardiographic improve prediction, detection treatment AF clinical practice. However, there limited data about significance combination novel prediction...
Abstract Background Exacerbated heart failure is a condition with high frequency of hospitalizations and mortality, especially in overweight patients. Screening treatment for sleep apnea can be helpful these Purpose To determine the phenotypic characteristics patients exacerbated failure. assess systolic diastolic function obstructive central apnea. follow one year to hospitalization mortality. Methods We conducted single-centre, prospective cohort study form 120 consecutive hospitalized...
Abstract Background The main factor responsible for atrial cardiomyopathy (ACM) is fibrillation (AF). It known that AF causes remodeling of the left atrium but its effects on right heart chambers and mortality are not well studied. Purpose To assess echocardiographic characteristics patients with long-standing paroxysmal their impact survival. Methods From 624 consecutive only 173 met inclusion criteria cardiomyopathy, defined as severely dilated indexed volume (LAVI) &gt;48 ml/m2,...
The objective of this work was to develop a scientifically sound rationale for the method reflex correction biliary tract dysfunction based on chronobiological data concerning functioning acupuncture points corresponding ducts. It shown that patients presenting with dyskinesia (i.e. forming desynchronism) experience shift both skin temperature and electrical resistance at points. chronoreflexotherapeutic technique employed in study makes it possible rapidly restore disturbed biorhythms...
Abstract Background Left ventricular (LV) global longitudinal strain (GLS) is a more sensitive parameter than ejection fraction in the assessment of LV function. It has been established as predictor cardiac death and adverse events. In patients with dilated cardiomyopathy (DCM) deformation twist mechanics are reduced varying degrees. Purpose The aim study was to determine different performance patterns DCM advanced heart failure (HF). Methods 52 HF NYHA class III-IV (62 ± 13 years, 36 males)...
Background: Telemedicine is an alternative to the standard consultation with a specialist during COVID-19 pandemic. Though their benefits are not well studied, phone consultations potential effective resource for providing medical and psycho-social help patients chronic diseases social isolation. Aim: To assess demographic clinical characteristics of patients, who looked cardiology on phone, most common reasons these consultations. Material Methods: We analyzed data 196 consecutive...