A5038622136- CRISPR and Genetic Engineering
- RNA regulation and disease
- Insect Resistance and Genetics
- Viral Infectious Diseases and Gene Expression in Insects
- Retinal Development and Disorders
- Advanced Memory and Neural Computing
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- Insect-Plant Interactions and Control
- Plant Virus Research Studies
- Entomopathogenic Microorganisms in Pest Control
ShanghaiTech University
2024
Center for Excellence in Brain Science and Intelligence Technology
2019
Chinese Academy of Sciences
2017-2019
Shanghai Institutes for Biological Sciences
2019
Institute of Zoology
2017
Helicoverpa armigera and zea are major caterpillar pests of Old New World agriculture, respectively. Both, particularly H. armigera, extremely polyphagous, has developed resistance to many insecticides. Here we use comparative genomics, transcriptomics resequencing elucidate the genetic basis for their properties as pests.
Adeno-associated virus (AAV) is a relatively safe and efficient vector for gene therapy. However, due to its 4.7-kb limit of cargo, SpCas9-mediated base editors cannot be packaged into single AAV vector, which hinders their clinical application. The development miniature becomes an urgent need. Un1Cas12f1 class II V-F-type CRISPR-Cas protein with only 529 amino acids. Although has been engineered editor in mammalian cells, the base-editing efficiency less than 10%, limits therapeutic...