A5089586606- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Kruppel-like factors research
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Eosinophilic Disorders and Syndromes
- CRISPR and Genetic Engineering
- Platelet Disorders and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Multiple Myeloma Research and Treatments
- Antioxidant Activity and Oxidative Stress
- Retinoids in leukemia and cellular processes
- Pediatric Pain Management Techniques
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Anesthesia and Pain Management
- Pituitary Gland Disorders and Treatments
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Pain Management and Opioid Use
- Mast cells and histamine
- Adrenal and Paraganglionic Tumors
Mackay Memorial Hospital
2013-2024
University of Pennsylvania
2020-2024
Mackay Medical College
2024
Clinical Research Management
2021
Most patients treated with US Food and Drug Administration (FDA)–approved chimeric antigen receptor (CAR) T cells eventually experience disease progression. Furthermore, CAR have not been curative against solid cancers several hematological malignancies such as cell lymphomas, which very poor prognoses. One of the main barriers to clinical success adoptive immunotherapies is dysfunction lack expansion and/or persistence after infusion. In this study, we found that CD5 inhibits activation...
Germline variations at JAK2, TERT, HBS1L-MYB and MECOM have been found to associate with myeloproliferative neoplasms (MPNs) in European populations. Whether these germline are associated MPNs Taiwanese population is obscure. Here we aimed evaluate the association of five (JAK2 46/1 haplotype tagged by rs12343867, JAK2 intron 8 rs12339666, TERT rs2736100, rs9376092 rs2201862) risk population. A total 178 MPN patients (109 essential thrombocythemia, 54 polycythemia vera 15 primary...
Abstract Background Despite the advances of therapies, multiple myeloma (MM) remains an incurable hematological cancer that most patients experience relapse. Tumor angiogenesis is strongly correlated with Human leukocyte antigen G (HLA-G) has been known as a molecule to suppress angiogenesis. We aimed investigate whether soluble HLA-G (sHLA-G) was involved in relapse MM. Methods first investigated dynamics serum sHLA-G, vascular endothelial growth factor (VEGF) and interleukin 6 (IL-6) 57...
// Ken-Hong Lim 1,2,3,4 , Caleb Gon-Shen Chen 2,3,4,5 Yu-Cheng Chang 2,3,4 Yi-Hao Chiang 2,3 Chen-Wei Kao 3 Wei-Ting Wang Chiao-Yi Ling Huang Ching-Sung Lin Chun-Chia Cheng Hung-I 6 Nai-Wen Su Johnson 2 Yi-Fang Ming-Chih Ruey-Kuen Hsieh Huan-Chau and Yuan-Yeh Kuo 1 Graduate Institute of Oncology, National Taiwan University College Medicine, Taipei, Department Internal Division Hematology MacKay Memorial Hospital, Medical Research, Laboratory Good Clinical Research Center, Tamsui District,...
Abstract Tyrosine kinase inhibitors (TKIs) that target BCR-ABL are the frontline treatments in chronic myeloid leukemia (CML). Growing evidence has shown TKIs also enhance immunity. Since gamma-delta T (γδT) cells possess potent anticancer capability, here we investigated potential involvement of γδT TKI for CML. We characterized isolated from chronic-phase CML patients before and during treatments. expression increased significantly who achieved major molecular response (MMR) deep (DMR)....
Abstract Aims: The optimal maintenance therapy for patients with acute promyelocytic leukemia (APL) who achieved complete remission (CR) and consolidation chemotherapy is still controversial. Whether the use of arsenic trioxide (ATO) alone or along all‐trans retinoic acid (ATRA) improves overall survival (OS) disease‐free (DFS) debated. Methods: A retrospective reivew was conducted 20 diagnosed APL according to French – American British system. After achieving CR receiving chemotherapy, nine...
][6] KIT D816V mutation can be detected in .90% of SM patients. 7Interestingly, multilineage involvement and multimutations other genes such as SRSF2, ASXL1, RUNX1 are frequently advSM. 8[12] Recently, the multikinase inhibitor midostaurin was approved for treatment advSM on basis its clinical activity 116 adults with 13Currently, both primary acquired resistance to challenges advSM.The complexity dynamics mutational profiles midostaurin-treated have been studied by using serial...
Clinical evidence for the rapidity and effectiveness of fentanyl buccal soluble film (FBSF) in reducing pain intensity breakthrough cancer (BTcP) remains inadequate. This study aimed to evaluate efficacy FBSF proportional around-the-clock (ATC) opioid regimens rapidly relieving BTcP episodes by determining percentage patients requiring further dose titration.
A 62-year-old man had body weight loss and intermittent right upper quadrant abdominal discomfort for over a year. He was diagnosed as having adrenal cortical carcinoma with lung metastasis. received debulking resection (right adrenalectomy), six cycles of monthly intravenous chemotherapy EDP oral mitotane therapy. is still alive two half years after starting treatment. Debulking surgery plus adjuvant may provide good outcome even in metastatic disease.