A5031646248- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Indoor Air Quality and Microbial Exposure
- Advanced Chemical Sensor Technologies
- Plant Pathogens and Fungal Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mesenchymal stem cell research
- Neurobiology and Insect Physiology Research
- Insect Pest Control Strategies
- Olfactory and Sensory Function Studies
- CRISPR and Genetic Engineering
- Ovarian cancer diagnosis and treatment
- Cardiac pacing and defibrillation studies
- Medical Imaging and Pathology Studies
- Essential Oils and Antimicrobial Activity
- Multiple Myeloma Research and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Invertebrate Immune Response Mechanisms
- Tissue Engineering and Regenerative Medicine
- CAR-T cell therapy research
- Protein Degradation and Inhibitors
- Cholinesterase and Neurodegenerative Diseases
- Medicinal Plants and Neuroprotection
- Atrial Fibrillation Management and Outcomes
- Biochemical and biochemical processes
University of Pennsylvania
2023-2024
Monmouth Medical Center
2020-2022
Rutgers, The State University of New Jersey
2010-2021
Johnson University
2020-2021
Saint Barnabas Medical Center
2020-2021
Hackensack University Medical Center
2015-2020
University of Alabama
2007-2012
University of Nebraska Medical Center
2007
Emory University
2007
Stowers Institute for Medical Research
2007
Novel species of fungi described in this study include those from various countries as follows: Australia , Chaetomella pseudocircinoseta and Coniella pseudodiospyri on Eucalyptus microcorys leaves, Cladophialophora eucalypti Teratosphaeria dunnii Vermiculariopsiella Cylindrium grande Hypsotheca eucalyptorum grandis Elsinoe salignae saligna Marasmius lebeliae litter regenerating subtropical rainforest, Phialoseptomonium (incl. gen. nov.) × camaldulensis Phlogicylindrium pawpawense...
Catastrophic loss of dopaminergic neurons is a hallmark Parkinson's disease. Despite the recent identification genes associated with familial parkinsonism, etiology most disease cases not understood. Environmental toxins, such as herbicide paraquat, appear to be risk factors, and it has been proposed that susceptibility influenced by genetic background. The model organism Drosophila an advantageous system for factors. Genes affect dopamine homeostasis are candidate because itself implicated...
Most patients treated with US Food and Drug Administration (FDA)–approved chimeric antigen receptor (CAR) T cells eventually experience disease progression. Furthermore, CAR have not been curative against solid cancers several hematological malignancies such as cell lymphomas, which very poor prognoses. One of the main barriers to clinical success adoptive immunotherapies is dysfunction lack expansion and/or persistence after infusion. In this study, we found that CD5 inhibits activation...
Significance Poor air quality from fungal growth in water-damaged, moldy buildings/residences is correlated with a negative impact on human health. The volatile organic compound 1-octen-3-ol commonly emitted by molds and responsible for much of the distinctive odor associated colonization. Using Drosophila model, we demonstrate via genetic, biochemical, immunological studies that causes dopamine neuron degeneration through disruption handling. These data exerts toxicity homeostasis may...
Many volatile organic compounds (VOCs) are found in indoor environment as products of microbial metabolism. In damp environments, fungi associated with poor air quality. Some epidemiological studies have suggested that VOCs a negative impact on human health. Our study was designed to provide reductionist approach toward studying fungal VOC–mediated toxicity using the inexpensive model organism, Drosophila melanogaster, and pure chemical standards several important VOCs. Low concentrations...
Using a Drosophila model, we previously demonstrated truncated life span and neurotoxicity with exposure to 1-octen-3-ol, the volatile organic compound (VOC) responsible for much of musty odor found in mold-contaminated indoor spaces. In this report, using biochemical immunological assays, show that 0.5 ppm 1-octen-3-ol induces nitric oxide (NO) mediated inflammatory response hemocytes, innate immune cells. Moreover, exposed brains increased peroxynitrite expression. An increase nitrite...
Abstract Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma. Up to 40% patients with DLBCL display refractory disease or relapse after standard chemotherapy treatment (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone [R-CHOP]), leading significant morbidity mortality. The molecular mechanisms chemoresistance in remain incompletely understood. Using a cullin–really interesting new gene (RING) ligase-based CRISPR-Cas9 library, we...
Superstorm Sandy provided an opportunity to study filamentous fungi (molds) associated with winter storm damage. We collected 36 morphologically distinct fungal isolates from flooded buildings. By combining traditional morphological and cultural characters analysis of ITS sequences (the DNA barcode), we identified 24 species that belong eight genera: Penicillium (11 species), Fusarium (four Aspergillus (three Trichoderma (two one each Metarhizium, Mucor, Pestalotiopsis, Umbelopsis. Then,...
Fungi are implicated in poor indoor air quality and may pose a potential risk factor for building/mold related illnesses. emit numerous volatile organic compounds (VOCs) as alcohols, esters, ethers, ketones, aldehydes, terpenoids, thiols, their derivatives. The toxicity profile of these VOCs has never been explored model organism, which could enable the performance high throughput toxicological assays lead to better understanding mechanism toxicity. We have established reductionist...
Epidemiological studies link the herbicide paraquat to increased incidence of Parkinson's disease (PD). We previously reported that Drosophila exposed recapitulate PD symptoms, including region-specific degeneration dopaminergic neurons. Minocycline, a tetracycline derivative, exerts ameliorative effects in neurodegenerative models, . investigated whether our environmental toxin-based model could contribute an understanding cellular and genetic mechanisms minocycline action we assess...
Purpose: Patients undergoing breast cancer treatment experience financial burden that can lead to stress and affect access care. This study investigates the patients with face. Methods: Change in level of self-reported was evaluated by determining difference Comprehensive Score for Financial Toxicity-Functional Assessment Chronic Illness Therapy (COST-FACIT). The survey administered at baseline, 3, 6, 12 months within a rural center understand patterns burden. A higher score indicated less...
Inflammatory myofibroblastic tumor (IMT) previously known as inflammatory pseudotumor, plasma cell granuloma, pseudosarcoma, myxoid hamartoma or myofibrohistiocytic proliferation is recently recognized by World Health Organization (WHO) “IMT” and considered a rare benign of soft tissues occurring commonly in lung, liver mesentry omentum. IMT mainly identified lesion children young population. In this report, we describe case 93-year-old female urinary bladder with initial...
In previous work, our laboratory developed a Drosophila model for studying the adverse effects of fungal volatile organic compounds (VOCs) emitted by growing cultures molds. this report, we have extended these studies and compared toxic VOCs from living four molds isolated after Hurricane Katrina flooded home in New Orleans. Strains Aspergillus, Mucor, Penicillium, Trichoderma were grown with wild-type larvae products on developmental stages evaluated. Furthermore, heterozygous mutants...
Background: Large scale high quality and low cost production of clinical grade mesenchymal stem cells (MSCs) is critical for facilitating research potential cell therapies.Use Fetal Bovine/Calf serum (FBS/FCS) the application carries a risk transmission zoonosis, therefore alternative xeno-free culture techniques have been evaluated.The commercial products MSCs in and/or free media such as STEMPRO® MSC SFM MesenGro® are available but possibly not effective large MSCs.The usage human pooled...
A perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal neoplasm composed of cells with distinctive histologic, immunohistochemical, and genetic features. PEComas arising from various anatomical sites have been reported, but gastrointestinal are extremely entities. Here, we discuss the clinical pathological features PEComa transcription factor E3 (TFE3) translocation in 17-year old adolescent male presentation abdominal pain bleeding. Our case report provides insight into this...
BACKGROUND:Richter transformation (RT) is an uncommon clinicopathological condition referring to the development of aggressive lymphoma from chronic lymphocytic lymphoma/small (CLL/SLL) and characterized by sudden clinical deterioration with marked multifocal lymphadenopathy. Transformation CLL/SLL diffuse large B-cell most common (2-9%), but T-cell Hodgkin (HL) (0.4%) occur, although less frequently. CASE REPORT:A 68-year-old woman initially diagnosed presented hospital fever, weakness,...