A5030381175- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Infant Nutrition and Health
- Cytomegalovirus and herpesvirus research
- Neonatal Health and Biochemistry
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Blood donation and transfusion practices
Japanese Red Cross Society, Japan
2016-2025
Abstract Background In Japan, 41 million blood donations have been screened for hepatitis B virus (HBV) during the past 8.4 years using individual donation nucleic acid amplification testing (ID‐NAT) and antibody to core antigen (anti‐HBc) screening. Study Design Methods Transfusion‐transmitted HBV infection (TT‐HBV) incidence was examined. Donated implicated in TT‐HBV analyzed stage DNA levels. Causative strains were phylogenetically analyzed. Results Among 5162 (0.013%) ID‐NAT positives,...
Abstract Background In Japan, the risk of transfusion‐transmitted hepatitis B virus (TT‐HBV) infection has been reduced since 2014 by implementing individual donation nucleic acid amplification testing (ID‐NAT). Case Report A male repeat blood donor in his 20s converted positive for HBV DNA and surface antigen. Red cell concentrate from previous had transfused into a woman her 70s. Her serum showed positivity 62 days after transfusion. genome sequences across two regions were shown to be...
Hepatitis B virus (HBV)-positive individuals with isolated anti-HBs are found among HBV vaccine recipients and healthy blood donors no vaccination history. infectivity from transfusions derived such remains unclear.A male patient who received transfusion negative for individual donation-NAT, HBsAg anti-HBc but weakly positive developed typical transfusion-transmitted (TT)-HBV response. The responsible donor was a frequent repeat showing marked increase in titer without response 84 days after...
BACKGROUND The ultimate strategy to cope with transfusion‐transmitted hepatitis B virus (HBV) infection caused by transfusion of blood from donors historical HBV is reject all having anti‐HBV core antigen (anti‐HBc). However, this would result in a huge loss and subsequent inventory collapse. On the other hand, anti‐HBc–positive reportedly not infectious when containing more than 100 mIU/mL surface (anti‐HBs). STUDY DESIGN AND METHODS In Japan, has been used for if it contained 200 or...
BACKGROUND Cytomegalovirus (CMV) transmission to very‐low‐birth‐weight infants (VLBWIs) sometimes induces serious clinical symptoms. Although breast milk is considered a major source of transmission, transfusion‐transmitted CMV (TT‐CMV) infection often suspected when disease develops after transfusion. Thus, it clinically important distinguish between and milk–transmitted infections. STUDY DESIGN AND METHODS Study A: The incidence acquired was prospectively investigated in 65 VLBWIs. B: To...
Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) essentially affects organs and tissues. SARS‐CoV‐2 RNAemia is often associated with more cases of disease 2019 (COVID‐19) compared to without RNAemia. To determine the impact pandemic on transfusion medicine, particularly transfusion‐related infection, we examined frequency blood donation RNAemia, viral RNA (vRNA) concentration, any possibility transfusion‐transmitted infection (TTI) among recipients. Study...
Cytomegalovirus (CMV) infections in very-low-birthweight infants can lead to serious clinical consequences. When CMV-related symptoms occur after transfusion, CMV transmission is often attributed the transfusion products rather than breast milk. However, it sometimes difficult distinguish between transfusion-transmitted and milk-transmitted infections.A patient was born at 27 gestational weeks with a weight of 689 g. He transfused leukoreduced red blood cells (LR-RBCs), which were later...