A5012858137- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Molecular Sensors and Ion Detection
- Plant Virus Research Studies
- Luminescence and Fluorescent Materials
- Obstructive Sleep Apnea Research
- Plant-Microbe Interactions and Immunity
- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Sensors
- Intensive Care Unit Cognitive Disorders
- Plant Disease Resistance and Genetics
- Plant and Fungal Interactions Research
- Neuroscience of respiration and sleep
- Antibiotic Resistance in Bacteria
- Sleep and Wakefulness Research
- Anesthesia and Neurotoxicity Research
- Synthesis of Organic Compounds
- Vitamin C and Antioxidants Research
- Respiratory Support and Mechanisms
- Soybean genetics and cultivation
- Enzyme Catalysis and Immobilization
- FOXO transcription factor regulation
- COVID-19 Impact on Reproduction
- Synthesis and Biological Activity
Instituto Dante Pazzanese de Cardiologia
2025
Jilin Agricultural University
2025
Indiana University – Purdue University Indianapolis
2025
Zhejiang Chinese Medical University
2025
Zhejiang University
2025
Shaanxi Provincial People's Hospital
2023-2024
Second Affiliated Hospital of Zhejiang University
2024
Renmin Hospital of Wuhan University
2021-2023
Northeast Agricultural University
2020-2023
Wuhan University
2021-2023
P3N-PIPO, the only dedicated movement protein (MP) of potyviruses, directs cylindrical inclusion (CI) from cytoplasm to plasmodesma (PD), where CI forms conical structures for intercellular movement. To better understand potyviral cell-to-cell movement, we further characterized P3N-PIPO using Turnip mosaic virus (TuMV) as a model virus. We found that interacts with P3 via shared P3N domain and TuMV mutants lacking either or are defective in Moreover, PIPO is sufficient direct PD, whereas...
NONEXPRESSER OF PATHOGENESIS-RELATED GENES 1 (NPR1) is the master regulator of salicylic acid-mediated basal and systemic acquired resistance in plants. Here, we report that NPR1 plays a pivotal role restricting compatible infection by turnip mosaic virus, member largest plant RNA virus genus Potyvirus, such counteracted NUCLEAR INCLUSION B (NIb), viral RNA-dependent polymerase. We demonstrate NIb binds to SUMO-interacting motif 3 (SIM3) prevent SUMO3 interaction sumoylation, while...
Abstract This study investigates the potential of ellagic acid (EA), a phytochemical with antioxidant and anti-inflammatory properties, in managing perioperative neurocognitive disorders (PND). PND, which represents spectrum cognitive impairments often faced by elderly patients, is principally linked to surgical anesthesia procedures, heavily impacted oxidative stress hippocampus microglia-induced neuroinflammation. Employing an aged mice model subjected abdominal surgery, we delve into EA's...
Introduction: The prevalence of carbapenem-resistant Pseudomonas aeruginosa is increasing persistently, particularly in burn ward isolates. Here, we investigate the a provincial-level hospital at Kunming, Yunnan province, China. Methods: A total 118 P. strains were isolated from 57 hospitalized patients, and their MICs measured. Carbapenem-resistant isolates selected for multilocus sequence typing (MLST). Carbapenem-resistance mechanisms identified by examining carbapenemase genes OprD...
Abstract Alternative RNA splicing is an essential mechanism linking genetic variation to human diseases. While the signals from genome-wide association studies (GWAS) have been linked expression quantitative trait loci (eQTL) in previous studies, further work needed better elucidate relationship other regulatory mechanisms, such as QTLs (sQTL). Here, we performed a sQTL analysis identify variants that might affect 1,010 non–small cell lung cancer (NSCLC) samples The Cancer Genome Atlas....
In recent years, multidrug resistance in pathogenic bacteria has become increasingly serious, causing serious harm to the livestock and poultry breeding industries posing severe challenges its clinical prevention treatment; therefore, development of new antibacterial agents is urgently needed. We previously isolated Bacillus velezensis CB6, which exhibits broad-spectrum activity, from Changbaishan China. this study, multidrug-resistant Escherichia coli B2(MDR E. B2) was used as an indicator...
Abstract Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, affecting lymphoid cells of both B and T lineages. Most ALL are auxotrophic for asparagine, a nonessential amino acid protein synthesis, due to low expression asparagine synthetase (ASNS), rate-limiting enzyme de novo biosynthesis asparagine. Standard treatment takes advantage this vulnerability by giving patients L-asparaginase, bacterial that depletes circulating However, previous work from our lab others has...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA novel synthesis of 2-aminochromones via phosgeniminium saltsJoel Morris, Donn G. Wishka, and Yue FangCite this: J. Org. Chem. 1992, 57, 24, 6502–6508Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/jo00050a025https://doi.org/10.1021/jo00050a025research-articleACS PublicationsRequest reuse permissionsArticle Views492Altmetric-Citations35LEARN...
Chronic obstructive pulmonary disease (COPD) and sleep apnea (OSA) are associated with polycythemia. However, there still remain unanswered questions about the relationship between overlap syndrome (OVS), where OSA COPD coexist, Here, we aimed to establish prevalence of polycythemia in OVS patients explore impact on polycythemia.Patients underwent overnight polysomnography (PSG), function tests, echocardiography, complete blood counts. All were ethnic Han Chinese free prolonged oral...
Heinong 84 is one of the major soybean varieties growing in Northeast China, and resistant to infection all strains mosaic virus (SMV) region including most prevalent strain, N3. However, resistance gene(s) mechanism are still elusive. In this study, genetic next-generation sequencing (NGS)-based bulk segregation analysis (BSA) were performed map gene using a population from cross susceptible cultivar strain N3, Zhonghuang 13. Results show that controlled by dominant on chromosome Further...
Abstract Cyclodehydration of a series salicylacetamides with triflic anhydride efficiently provided the corresponding 2-aminochromone. The use polyphosphoric ester for this process was somewhat less effective.
Abstract A synthesis of diethyl carbonate through transesterification propylene and ethanol, coproducing useful glycol, was carried out in the presence sodium ethoxide as catalyst. The effects reaction parameters such catalyst concentration, mole ratio ethanol to temperature on transesterfication were investigated. results showed that is reversible with a equilibrium conversion about 64 % at an 8.0 303 K. kinetic model proposed based mechanism. estimated by Runge‐Kutta method. statistical...
To analyze the prognostic factors and survival rate of lung cancer patients with obstructive sleep apnea (OSA) by nomogram. The nomogram was established a development cohort (n = 90), validation included 38 patients. Factors in were identified Cox hazard analysis. We tested accuracy nomograms discrimination calibration, plotted decision curves to assess benefits nomogram-assisted decisions. There significant difference sex, hypopnea index (AHI), Tumor Node Metastasis (TNM), coronary heart...
Abstract Potato virus X (PVX) is a widely distributed viral pathogen that causes significant losses in potato production by co-infecting with Y or A. In this study, the resistance of 23 cultivars to PVX was dissected detail using infectious clone containing yellow fluorescent protein (YFP). Among them, four (Longshu-3, Eugene, Atlantic and Waiyin-2) were found carry an Rx gene confers extreme PVX; one cultivar (Waiyin-1) displayed partial able delay infection ~ 5 days; while rest eighteen...