A5015863700- Rheumatoid Arthritis Research and Therapies
- Vasculitis and related conditions
- Musculoskeletal synovial abnormalities and treatments
- Systemic Lupus Erythematosus Research
- Otitis Media and Relapsing Polychondritis
- Spondyloarthritis Studies and Treatments
- Bone and Joint Diseases
- Autoimmune and Inflammatory Disorders Research
- Orthopedic Infections and Treatments
- Systemic Sclerosis and Related Diseases
- Orthopedic Surgery and Rehabilitation
- Salivary Gland Disorders and Functions
- Salivary Gland Tumors Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Renal Diseases and Glomerulopathies
- Peripheral Nerve Disorders
- Lymphadenopathy Diagnosis and Analysis
- Myasthenia Gravis and Thymoma
- Ocular Diseases and Behçet’s Syndrome
- Platelet Disorders and Treatments
- Retinal and Optic Conditions
- Infectious Diseases and Tuberculosis
- Inflammatory Bowel Disease
- Musculoskeletal Disorders and Rehabilitation
- Sarcoidosis and Beryllium Toxicity Research
Rigshospitalet
2011-2025
University of Copenhagen
2006-2025
Copenhagen University Hospital
2009-2024
Glostrup Hospital
2013-2024
Center for Rheumatology
2015-2021
Hvidovre Hospital
2006-2021
University of Turin
2018
Pomeranian Medical University
2018
Capital Region of Denmark
2010-2017
Charité - Universitätsmedizin Berlin
2013
To define the elementary ultrasound (US) lesions in giant cell arteritis (GCA) and to evaluate reliability of assessment US according these definitions a web-based exercise.Potential normal abnormal findings temporal extracranial large arteries were retrieved by systematic literature review. As subsequent step, structured Delphi exercise was conducted involving an expert panel Outcome Measures Rheumatology (OMERACT) Large Vessel Vasculitis Group agree appearance key vasculitis arteries. The...
Abstract The objective of the study was, with multidetector computed tomography (CT) as reference method, to determine whether bone erosions in rheumatoid arthritis (RA) metacarpophalangeal (MCP) joints detected magnetic resonance imaging (MRI) and ultrasonography (US), but not radiography, represent true erosive changes. We included 17 RA patients at least one, previously detected, radiographically invisible MCP joint MRI erosion, four healthy control individuals. They all underwent CT,...
<h3>Aim</h3> To monitor joint inflammation and destruction in rheumatoid arthritis (RA) patients receiving adalimumab/methotrexate combination therapy using MRI ultrasonography. assess the predictive value of ultrasonography for erosive progression on CT compare MRI/ultrasonography/radiography erosion detection/monitoring. <h3>Methods</h3> Fifty-two biological-naive RA were followed with repeated (0/6/12 months) clinical/biochemical assessments during therapy. <h3>Results</h3> No overall or...
Abstract Background The objectives of the present study were, with multidetector computed tomography (CT) as reference method, to determine performance magnetic resonance imaging (MRI) and radiography for detection bone erosions in rheumatoid arthritis wrist bones, test whether measuring volumes on CT MRI is reproducible correlated semiquantitative assessments (scores) CT, radiography. Methods Seventeen patients four healthy control individuals underwent one wrist, performed same day. was a...
To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity giant cell arteritis (GCA) and evaluate its metric properties.The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise conducted using images bilateral common temporal arteries, parietal frontal branches as well axillary arteries from 16 patients with...
<h3>Objectives:</h3> To investigate intramodality and intermodality agreements of CT MRI erosion volumes in metacarpophalangeal (MCP) joints rheumatoid arthritis (RA), to compare the with scores for CT, radiography. <h3>Methods:</h3> In total, 17 patients RA four healthy controls underwent unilateral radiography second fifth MCP one hand. Erosion (using OSIRIS software) were determined from (scores only). <h3>Results:</h3> detected 77, 62 12 erosions, respectively. On mean volume was 26...
In rheumatoid arthritis (RA), radiographic progression may occur despite clinical remission. This be explained by subclinical inflammation. Magnetic resonance imaging (MRI) provides a greater sensitivity than examination and radiography for assessing disease activity. Our objective was to determine the MRI characteristics of RA patients in remission or low activity (LDA) state.Databases from 6 cohorts were collected 5 international centers. according Disease Activity Score28-C-reactive...
Objective. To assess the predictive value of magnetic resonance imaging (MRI)-detected subclinical inflammation for subsequent radiographic progression in a longitudinal study patients with rheumatoid arthritis (RA) clinical remission or low disease activity (LDA), and to determine cutoffs an MRI inflammatory acceptable state RA which rarely occurs. Methods. Patients [28-joint Disease Activity Score-C-reactive protein (DAS28-CRP) < 2.6, n = 185] LDA (2.6 ≤ DAS28-CRP 3.2, 69) data were...
Objective. To test the reliability of Outcome Measures in Rheumatology Clinical Trials (OMERACT) consensus-based ultrasound definitions for normal and vasculitic temporal axillary arteries patients with giant cell arteritis (GCA) controls. Methods. A preliminary 1-day meeting a full 3-day fulfilling OMERACT Ultrasound Group guidelines were held. Temporal examined at 2 timepoints by 12 sonographers on 4 GCA The aim was to inter- intrareader findings, halo sign, compression sign. In both...
Abstract Objectives Musculoskeletal [MSK] manifestations in patients with inflammatory bowel disease [IBD] are common and associated poorer outcomes. Hence, early detection is important to optimally tailor treatment. We aimed determine the prevalence distribution of lesions peripheral joints entheses newly diagnosed IBD patients. Design Patients from a prospective population-based inception cohort were consecutively included. Data on MSK symptoms collected by questionnaires structured...
<h3>Objective:</h3> With computed tomography (CT) and radiography, to investigate if repair of bone erosions, defined as regression erosion scores, occurs during adalimumab treatment patients with rheumatoid arthritis (RA). <h3>Methods:</h3> Fifty-two RA, naïve biological agents, at least two low-grade radiographic erosions in the wrist or metacarpophalangeal (MCP) joints same (index) hand, initiated 40 mg subcutaneously every other week. Thirty-five completed study (median age 61 years...
Objective. To develop and validate a magnetic resonance imaging (MRI) method of assessment joint space narrowing (JSN) in rheumatoid arthritis (RA). Methods. Phase A: JSN was scored 0–4 on MR images 5 RA patients 3 controls at 15 wrist sites 2nd–5th metacarpophalangeal (MCP) joints by 8 readers (7 once, one twice), using preliminary scoring system. B: Image review, discussion, consensus definition, revised C: 4 were system (4 results compared with radiographs [Sharp-van der Heijde (SvdH)...
Aim To describe salivary gland involvement in patients suspected of Sjögren’s syndrome (SS) using the OMERACT Ultrasound Scoring System for SS. Next, different ultrasound cut-offs, to assess performance scoring system diagnosis and fulfilment 2016 ACR/EULAR SS classification criteria. Methods All referred our department with a suspicion 12-month period were included. underwent grey-scale parotid submandibular glands prior clinical examination, Schirmer’s test, unstimulated flow, blood...
The microanatomic basis for formation of erosions in inflammatory arthritis is incompletely understood but thought to be related bare areas and the associated cartilage-synovium junction. purpose this study was test hypothesis that erosion-prone sites are with microdamage macroscopically normal joints.Histologic evaluation performed on 20 collateral ligaments (CLs) from metacarpophalangeal (MCP) proximal interphalangeal (PIP) joints 5 cadavers. In addition, MCP (n = 17) PIP 3) patients...
<h3>Objectives</h3> To determine the accuracy of ultrasonography (US) for bone erosion detection in different areas rheumatoid arthritis (RA) metacarpophalangeal (MCP) joints with multislice CT as reference method. Second, to establish necessary volume loss on US reliably detect it an erosion, and finally compare two semiquantitative US-erosion scoring methods. <h3>Methods</h3> The 2nd–5th MCP 49 patients RA were examined by US, evaluated presence each joint quadrant. On CT, was scored...
Giant cell arteritis (GCA) is a medical and ophthalmological emergency due to risk of stroke sudden irreversible loss vision. Fast accurate diagnosis important prevent complications long-term high dose glucocorticoids toxicity. Temporal artery biopsy gold standard for diagnosing GCA. However, temporal ultrasound fast non-invasive procedure which may provide supplement or an alternative biopsy. This study assesses the diagnostic performance in Examination results patients suspected having GCA...
Abstract Background Subclinical synovitis by ultrasound is a frequent finding in rheumatoid arthritis (RA) patients remission and has been shown to be related erosive progression, risk of flare unsuccessful drug tapering, but it not investigated how DAS28 T2T-steered strategy routine care affects the presence subclinical RA remission. The aim current study was investigate ultrasound-detected inflammation long-term receiving either biological or conventional disease-modifying anti-rheumatic...
Objective Ultrasonography is crucial for diagnosing giant cell arteritis (GCA); however, training opportunities are rare. This study tested the reliability of ultrasonography findings and measurements intima-media thickness (IMT) among experts by using phantoms axillary (AA) temporal arteries (TA) created with high-resolution 3D printing. Methods Twenty-eight participants from 12 European countries received eight sets AA superficial TA (including common, frontal parietal branches), which...
Abstract Objective Salivary gland ultrasound (SGUS) is a non-invasive tool for the evaluation of parenchymal changes related to primary Sjögrens disease (pSjD) with potential reduce need minor salivary biopsies when diagnosing patients pSjD. The aim was assess agreement between SGUS findings and biopsy results in suspected Methods All referred suspicion pSjD scheduled diagnostic were included period 2017–2021. underwent parotid submandibular glands bilaterally, Schirmer’s test, unstimulated...
Objective. To test the intrareader and interreader reliability of assessment joint space narrowing (JSN) in rheumatoid arthritis (RA) wrist metacarpophalangeal (MCP) joints on magnetic resonance imaging (MRI) computed tomography (CT) using newly proposed OMERACT-RAMRIS JSN scoring method, to compare MRI, CT, radiography. Methods. After calibration readers, MRI CT images second fifth MCP from 14 patients with RA 1 healthy control were assessed twice for by 3 blinded clinical data. Radiographs...
Objective. To assess the intrareader and interreader agreement sensitivity to change of Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis Magnetic Resonance Imaging Joint Space Narrowing (RAMRIS-JSN) score rheumatoid arthritis (RA) wrist a longitudinal multireader exercise. Methods Coronal T1-weighted MR image sets 1 from 20 patients with early RA were assessed twice for JSN at 17 sites baseline after 36 or 60 months by 4 readers blinded patient data but not time order. The...