A5062658364- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Musculoskeletal synovial abnormalities and treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Salivary Gland Disorders and Functions
- S100 Proteins and Annexins
- Biomarkers in Disease Mechanisms
- Vasculitis and related conditions
- Orthopedic Surgery and Rehabilitation
- Musculoskeletal Disorders and Rehabilitation
- Otitis Media and Relapsing Polychondritis
- Monoclonal and Polyclonal Antibodies Research
- Toxin Mechanisms and Immunotoxins
- Lymphoma Diagnosis and Treatment
- Tendon Structure and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Immunodeficiency and Autoimmune Disorders
- Gout, Hyperuricemia, Uric Acid
- Oral Health Pathology and Treatment
- Diversity and Career in Medicine
- Muscle and Compartmental Disorders
- Myofascial pain diagnosis and treatment
Charles University
2014-2025
Institute of Rheumatology
2016-2025
O2 Czech Republic (Czechia)
2023
University of Southampton
2018
University of Leeds
2018
OMERACT Patient Research Partner Network
2015
To define the elementary ultrasound (US) lesions in giant cell arteritis (GCA) and to evaluate reliability of assessment US according these definitions a web-based exercise.Potential normal abnormal findings temporal extracranial large arteries were retrieved by systematic literature review. As subsequent step, structured Delphi exercise was conducted involving an expert panel Outcome Measures Rheumatology (OMERACT) Large Vessel Vasculitis Group agree appearance key vasculitis arteries. The...
To develop ultrasound (US) definitions and a US novel scoring system for major salivary gland (SG) lesions in patients with primary Sjögren's syndrome (pSS) to test their intrareader inter-reader reliability using video clips.Twenty-five rheumatologists were subjected three-round, web-based Delphi process order agree on (1) scanning procedure of ultrasonography (SGUS): parotid, submandibular sublingual glands (PG, SMG SLG); (2) the elementary SGUS syndrome; (3) grading changes. The experts...
To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity giant cell arteritis (GCA) and evaluate its metric properties.The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise conducted using images bilateral common temporal arteries, parietal frontal branches as well axillary arteries from 16 patients with...
Objectives The main objective was to generate a GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis and test its reliability. To this end, we assessed the validity, feasibility applicability of ultrasound assessment finger entheses incorporate them into scoring system. Methods study consisted stepwise process. First, cadaveric specimens, identified enthesis sites fingers by gross anatomy, then verified presence entheseal tissue histological samples. We selected be...
<h3>Objective</h3> To develop the first ultrasound scoring system of tendon damage in rheumatoid arthritis (RA) and assess its intraobserver interobserver reliability. <h3>Methods</h3> We conducted a Delphi study on ultrasound-defined RA among 35 international rheumatologists with experience musculoskeletal ultrasound. Twelve patients were included assessed twice by 12 rheumatologists-sonographers. Ultrasound examination for B mode five wrist extensor compartments (extensor carpi radialis...
Objective: To estimate the annual incidence and prevalence of psoriatic arthritis (PsA), ankylosing spondylitis (AS), reactive (ReA) in a sample Czech population.Methods: The population-based study was conducted two regions Republic (with total population 186000 inhabitants) 2002–2003. Incident cases were registered on condition confirming definite diagnosis according to existing classification criteria during period (1 March 2002 1 2003). Prevalence studied basis identification established...
To assess the reliability of consensually agreed US definitions major salivary gland lesions and scoring system for assessment in patients with SS.Nine experienced sonographers scanned read images both parotid glands (PGs) submandibular (SMGs) eight primary secondary SS two rounds. A four-grade semi-quantitative was applied B-mode morphological lesions: grade 0, normal; 1, mild inhomogeneity without anechoic or hypoechoic areas; 2, moderate focal 3, severe diffuse an- areas occupying entire...
The aim of this exercise from the OMERACT Ultrasound subgroup on Sjögren's syndrome was to develop and assess reliability a consensus-based semiquantitative colour Doppler US scoring system for pathologic salivary gland vascularization in patients with primary (pSS).Using Delphi method, bilateral parotid submandibular glands developed tested static images (9 pSS 9 sonographers). Intra-reader inter-reader grading were computed by weighted Cohen Light's kappa analysis, respectively.The score...
: In the ULTIMATE study with an open label extension, we assessed long-term effect of secukinumab at tissue level on synovitis and enthesitis, across all psoriatic arthritis (PsA) manifestations, using both clinical evaluations power Doppler ultrasonography (PDUS). This randomised, placebo-controlled, Phase 3 (ULTIMATE) included biologic-naïve patients PsA active PDUS inadequate response to conventional synthetic disease-modifying antirheumatic drugs. The consisted treatment periods; in...
Calprotectin may be a sensitive biomarker of rheumatoid arthritis (RA) disease activity.In the current study, we investigated whether calprotectin is better than CRP for predicting clinical activity and ultrasound parameters in patients with RA.A total 160 RA underwent (swollen joint count-SJC, tender count-TJC, Disease Activity Score-DAS28, Clinical Index-CDAI, simplified Index-SDAI) (German US7) examination. laboratory measures were correlated findings using Spearman´s correlation...
Objective To assess the construct validity of novel Outcome Measures in Rheumatology (OMERACT) ultrasound (US) semiquantitative scoring system for morphological lesions major salivary glands by comparing it with magnetic resonance imaging (MRI) and unstimulated whole flow rates (U-WSFRs) patients primary Sjögren syndrome (pSS). Methods Nine sonographers applied OMERACT 0-3 grayscale parotid (PGs) submandibular (SMGs) 11 pSS who also had MRIs performed. These were evaluated 2 radiologists...
Abstract Background The presence of ACPA significantly increases the risk developing RA. Dysregulation lymphocyte subpopulations was previously described in Our objective to propose predictive model for progression clinical arthritis based on peripheral subsets and individuals who are at Methods study included 207 at-risk defined by arthralgias either additional positivity or meeting EULAR definition clinically suspect arthralgia. For construction models, 153 with symptom duration ≥12 months...
Restoring normal physical functioning is a major therapeutic aim in the management of rheumatoid arthritis (RA). It unknown, whether extent synovial inflammation quantified by musculoskeletal ultrasound (US) can predict current or future capacity for functioning. To answer this question we investigated longitudinal relationship between function assessed health assessment questionnaire (HAQ) and German 7-joint score (US7S) prospective cohort patients with RA. Patients RA (n = 185 (46 incident...
Objective Clinical remission in some patients with rheumatoid arthritis (RA) may be associated ongoing synovial inflammation that is not always detectable on clinical examination or reflected by laboratory tests but can visualized musculoskeletal ultrasound. The goal of our study was to determine the levels serum calprotectin, a major leukocyte protein, RA and investigate ability calprotectin distinguish ultrasound-defined from those residual ultrasound subclinical inflammation. Methods...
Abstract Individuals carrying anti-citrullinated protein antibodies (ACPA) are considered at high risk of developing rheumatoid arthritis (RA). The altered expression miRNAs contributes to the pathogenesis RA. We aimed identify differentially expressed in peripheral blood ACPA-positive individuals with arthralgia RA compared healthy controls (HC) and determine their implications preclinical phase A comprehensive analysis revealed dysregulation miR-451 mononuclear cells (PBMC) plasma from...
Individuals carrying antibodies against citrullinated proteins (ACPA) are at high risk of developing RA. EULAR provided a clinical definition individuals with arthralgia suspicious for progression to RA (clinically suspect arthralgia, CSA). The alteration monocyte subpopulations in patients established has been previously described. We analysed peripheral blood RA.We included 70 at-risk individuals, defined as having without arthritis and being either ACPA+ or meeting the CSA definition, 23...
<h3>Background</h3> In a systematic literature review (SLR), we identified halo sign, stenosis, occlusion, compression sign and decreased vessel wall pulsation as elementary ultrasound (US) lesions in giant cell arteritis (GCA). <h3>Objectives</h3> To establish consensus-based definitions for the key US GCA. <h3>Methods</h3> We invited 25 rheumatologists from 13 countries experienced musculoskeletal vascular to participate Delphi exercise. Based on results SLR international expert consensus...