A5069449538- Inflammatory Myopathies and Dermatomyositis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Muscle Physiology and Disorders
- Rheumatoid Arthritis Research and Therapies
- Immunodeficiency and Autoimmune Disorders
- Muscle and Compartmental Disorders
- S100 Proteins and Annexins
- Eosinophilic Disorders and Syndromes
- Biomarkers in Disease Mechanisms
- Clusterin in disease pathology
- Systemic Sclerosis and Related Diseases
- Parkinson's Disease and Spinal Disorders
- Gout, Hyperuricemia, Uric Acid
- Nuclear Structure and Function
- Exercise and Physiological Responses
- Heat shock proteins research
- Musculoskeletal Disorders and Rehabilitation
- Cell Adhesion Molecules Research
- Dermatological and Skeletal Disorders
- Genetic Neurodegenerative Diseases
- Peripheral Neuropathies and Disorders
- Metabolism and Genetic Disorders
- Receptor Mechanisms and Signaling
- Pneumocystis jirovecii pneumonia detection and treatment
- Neurogenetic and Muscular Disorders Research
Institute of Rheumatology
2016-2025
Charles University
2015-2025
Shanxi Medical University
2021
Second Hospital of Shanxi Medical University
2021
Center for Rheumatology
2016-2018
Swiss Integrative Center for Human Health
2012
Czech Academy of Sciences, Institute of Physiology
2008
Groote Schuur Hospital
1992
University of Cape Town
1992
Objectives. Immune-mediated necrotizing myopathy (IMNM) is characterized by the predominant presence of necrotic muscle fibres in biopsy and variable response to immunosuppressive treatment. The aims this study were analyse temporal trend IMNM incidence our centre over past 10 years explore role statins as possible causative agents. Methods. A retrospective evaluation results, clinical laboratory data, including antibody associations all patients with idiopathic inflammatory newly diagnosed...
<h3>Objective</h3> Fibrin deposits are characteristic of the synovial tissues in rheumatoid arthritis (RA). Once citrullinated, fibrin becomes an autoantigen and is thought to contribute this way perpetuate disease. Our study aimed analyse responses RA fibroblasts (RASF) native citrullinated fibrin. <h3>Methods</h3> The transcriptome induced by RASF was approached with whole-genome-based gene expression arrays. upregulation selected pro-inflammatory genes confirmed additional primary cell...
In order to critically define the apparently widespread condition 'sports anemia', red cell indices and iron Status of male distance runners triathletes, female ballet dancers were compared non-exercising controls both sexes. The mean hemoglobin (Hb) levels all groups within normal ranges there was no difference between athletic control each sex. serum ferritin (SF) concentration (79.8 ug/1) significantly lower than that triathletes (123.5 (138.3 ug/1). Iron deficiency (SF < 12 ug/1,%...
Abstract Objectives To compare clinical characteristics, including the frequency of cutaneous, extramuscular manifestations and malignancy, between adults with anti-synthetase syndrome (ASyS) DM. Methods Using data regarding from MYONET registry, a cohort DM patients anti-Mi2/-TIF1γ/-NXP2/-SAE/-MDA5 autoantibodies, ASyS anti-tRNA synthetase autoantibodies (anti-Jo1/-PL7/-PL12/-OJ/-EJ/-Zo/-KS) were identified. Patients sine dermatitis or discordant dual autoantibody specificities excluded....
Myositis is a heterogeneous group of autoimmune diseases, with different pathogenic mechanisms contributing to the subsets disease. The aim this study was test whether autoantibody profile in patients myositis associated type I interferon (IFN) signature, as systemic lupus erythematous (SLE). Patients were prospectively enrolled and compared healthy controls SLE. Autoantibody status analysed using an immunoassay system immunoprecipitation. Type IFN activity whole blood determined direct gene...
Calprotectin may be a sensitive biomarker of rheumatoid arthritis (RA) disease activity.In the current study, we investigated whether calprotectin is better than CRP for predicting clinical activity and ultrasound parameters in patients with RA.A total 160 RA underwent (swollen joint count-SJC, tender count-TJC, Disease Activity Score-DAS28, Clinical Index-CDAI, simplified Index-SDAI) (German US7) examination. laboratory measures were correlated findings using Spearman´s correlation...
Abstract Objectives Objective of this work was to examine myomiR levels in plasma, skeletal muscle, and muscle cells patients with idiopathic inflammatory myopathy (IIM), their interrelations the disease-related clinical phenotypes effects disease-modifying 6-month training-intervention. Methods Samples vastus lateralis (n = 12/13) plasma 20/21) were obtained from IIM healthy controls, respectively. Muscle before after a training-intervention 7 patients. MyomiRs miR-1,-206,-133a,-133b...
Objective. To determine the prevalence, distribution, and clinical manifestations of arthritis in a cohort patients with idiopathic inflammatory myopathies (IIM). Associations autoantibody status HLA genetic background were also explored. Methods. Consecutive IIM treated single center included this cross-sectional study (n = 106). History arthritis, 68-joint 66-joint tender swollen joint index, features IIM, profiles obtained by examination, personal interview, review patient records....
Low levels of vitamin D have been associated with several autoimmune diseases. A growing body evidence supports the association skeletal muscle damage, regeneration, and energy lipid metabolism. The aim was to analyse its receptor (VDR) in tissue patients idiopathic inflammatory myopathies (IIM) relate them clinical parameters Forty-six IIM 67 healthy controls (HC) were included study. 27 participated a 24-week exercise intervention. Muscle biopsies obtained from 7 before/after training, 13...
The purpose of this study was to evaluate and compare the serum levels local expression resistin in patients with idiopathic inflammatory myopathies controls, determine relationship between levels, inflammation disease activity. Serum were determined 42 27 healthy controls. association among inflammation, global activity muscle strength examined. tissues from controls evaluated. Gene protein release resistin-stimulated mononuclear cells assessed. In myopathies, significantly higher than...
Abstract Background The structural and functional changes of the skeletal muscles in idiopathic inflammatory myopathies (IIM) caused by inflammation immune can be severely disabling. objective this study was to assess effect a 24-week program combining supervised training activities daily living (ADL), resistance, stability with home exercise for improving muscle function, compared home-based representing regular outpatient care. Methods Fifty-seven patients IIM were consecutively...
Restoring normal physical functioning is a major therapeutic aim in the management of rheumatoid arthritis (RA). It unknown, whether extent synovial inflammation quantified by musculoskeletal ultrasound (US) can predict current or future capacity for functioning. To answer this question we investigated longitudinal relationship between function assessed health assessment questionnaire (HAQ) and German 7-joint score (US7S) prospective cohort patients with RA. Patients RA (n = 185 (46 incident...
In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated specific clinical phenotypes suggesting a pathogenic role of adaptive immunity. We explored if autoantibody profiles HLA genetic variants and manifestations in IIM.
Objective Clinical remission in some patients with rheumatoid arthritis (RA) may be associated ongoing synovial inflammation that is not always detectable on clinical examination or reflected by laboratory tests but can visualized musculoskeletal ultrasound. The goal of our study was to determine the levels serum calprotectin, a major leukocyte protein, RA and investigate ability calprotectin distinguish ultrasound-defined from those residual ultrasound subclinical inflammation. Methods...
The aim of this study was to investigate the systemic and skeletal muscle levels atrophy-associated myokines in patients with idiopathic inflammatory myopathies (IIM) their association clinical characteristics myositis.A total 94 IIM 162 healthy controls were recruited. Of those, 20 28 underwent a biopsy. Circulating concentrations myostatin, follistatin, activin A TGF-β1 assessed by ELISA. expression associated genes involved myostatin signalling pathway tissue determined real-time PCR.We...