A5113913938- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Chemical Synthesis and Analysis
- Crystallization and Solubility Studies
- Phytochemistry and Biological Activities
- Superconducting Materials and Applications
- X-ray Diffraction in Crystallography
- Enzyme Catalysis and Immobilization
- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Organic and Inorganic Chemical Reactions
- Epigenetics and DNA Methylation
- Advanced Radiotherapy Techniques
- Physics of Superconductivity and Magnetism
- Microfluidic and Capillary Electrophoresis Applications
- Asymmetric Synthesis and Catalysis
- Magnetic confinement fusion research
- Fusion materials and technologies
- Bioactive Compounds and Antitumor Agents
- Coal Properties and Utilization
- Cancer, Stress, Anesthesia, and Immune Response
- Conservation Techniques and Studies
- Tea Polyphenols and Effects
- Quinazolinone synthesis and applications
- RNA modifications and cancer
Zhengzhou University
2009-2024
Ministry of Education of the People's Republic of China
2018-2024
Huazhong University of Science and Technology
2011-2024
Tongji Hospital
2024
University of Science and Technology of China
2018-2023
National Medical Products Administration
2019
Center for Drug Evaluation and Research
2018
Institute of Plasma Physics
2017-2018
Chinese Academy of Sciences
2017-2018
Fox Chase Cancer Center
2011-2012
Tumor microenvironment has a crucial role in cancer development and progression, whereas the mechanism of how it regulates angiogenesis is unclear. In this study, we simulated colorectal carcinoma by conditioned medium (CM) cell lines (SW620, HT-29, HCT116) supernatant or tissue homogenate to induce normal endothelial cells (NECs). We found that CM promoted tumor coercing NECs toward (TECs) with activation JAK/STAT3 signaling pathway. Antibody array analysis showed HT-29 contained numerous...
Experimental and modeling investigations on the DIII-D EAST tokamaks show attractive transport stability properties of fully noninductive, high poloidal-beta (βP) plasmas, their suitability for steady-state operating scenarios in ITER CFETR. A key feature high-βP regime is large-radius (ρ > 0.6) internal barrier (ITB), often observed all channels (ne, Te, Ti, rotation), responsible both excellent energy confinement quality properties. Experiments have shown that, with a ITB, very βN βP...
Abstract Jianshui purple pottery is a treasure in traditional Chinese ceramics. Its unique decorative techniques make it an excellent carrier of culture. With the development industrial technology, more bright colors chemical pigments are used ceramic decoration. This practice not only violates pure nature but also affects health pigments. In this paper, starting from raw materials pottery, combined with three local characteristic rock samples, minerals were tested by XRD, visible light...
Abstract Urinary‐modified nucleosides have a potential role as cancer biomarkers for number of malignant diseases. High performance liquid chromatography (HPLC) was combined with full‐scan mass spectrometry, MS/MS analysis and accurate measurements in order to identify purine purified from urine. Potential were assessed by their evident UV absorbance the HPLC chromatogram then further examined spectrometric techniques. In this manner, numerous modified identified urine samples patients...
Iron-based superconductors have caused great interest regarding high-field applications due to their good properties. A common fabrication route for 122-type wires and tapes is the ex situ powder-in-tube (PIT) process. From point of application in high magnetic field, where electromagnetic forces are present, conductor strength its tolerance mechanical load important issues. In order understand comparatively integrated critical current characterization Sr-122 tape under axial strain,...
A comprehensive work of the effects plasma current and heating schemes on divertor power footprint widths is carried out in experimental advanced superconducting tokamak (EAST). The widths, i.e., scrape-off layer heat flux decay length λq spreading S, are crucial physical engineering parameters for fusion reactors. Strong inverse scaling S with have been demonstrated both neutral beam (NB) lower hybrid wave (LHW) heated L-mode H-mode plasmas at inner target. For by combination two kinds...
Mesoporous silica nanoparticles could catalyze the <italic>de novo</italic> combination of benzodiazepine and isoindolinone, giving biologically relevant benzodiazepine-fused isoindolinone pseudo natural products.
Inductance is an essential parameter of a high-temperature superconducting (HTS) magnet. We have found that the inductance HTS magnets would vary with temperatures and transport currents. The input output properties magnet will change due to variation inductance. In this paper, electromagnetic model has been built according characteristics tapes analyze characteristic magnets. Four coils made verify model. result coil experiments basically agrees simulation results. According study, in can...
A series of small-membered heterocycle probes, so-called azaheterocycle-containing diphenylmethanol chiral solvating agents (CSAs), have been developed for NMR enantiodiscrimination. These sensors were readily synthesized inexpensive and efficiently used the analysis alpha-substituted carboxylic acids. The sensing method was operationally simple processing straightforward. Notably, we propose (S)-aziridinyl as a promising CSA, which has excellent discriminating properties offers multiple...
Skp1-CUL1-ROC1-F-box E3 ubiquitin ligases' main component S-phase kinase-associated protein 2 (Skp2) is responsible for specifically recognizing ubiquitination-modified substrates to be degraded such as p27 and p21 in the case of binding with adaptor Cks1. Pharmacological inhibition Skp2 has exhibited promising antitumor activity. Herein, we present design optimization a series [1,2,4]triazolo[1,5-
ABSTRACT The separation of rac‐o ‐chloromandelic acid 1 with enantiopure aryloxypropylamine via diastereomeric salt formation was investigated. ( R )‐ o , a key intermediate for the antithrombotic agent clopidogrel, obtained in 65% yield and 98% ee by Dutch resolution rac ‐ S )‐2‐hydroxyl‐3‐( p ‐chlorophenoxy) propylamine 5 as resolving ‐nitrophenoxy) 4 nucleation inhibitor. Chirality 24:1013–1017, 2012 . © Wiley Periodicals, Inc.
Abstract A series of novel Mahkoside derivatives was synthesized, and their in vitro cytotoxic activities were evaluated against the human cancer cell line Ec‐9706. Preliminary structure–activity relationship study showed compounds 7 8 have obvious (IC50: 30.0 12.5 µg · mL−1, respectively).
Biosafety of pathogenic microbiology laboratories generally highlights the use protective equipment, procedures, and operating practices to protect personnel environment from potentially hazardous biological materials. Under current complex situation where traditional non-traditional biosafety issues coexist, laboratory-acquired infection (LAI) microorganisms may cause illness, disability even death. Pathogenic also be carried surrounding environment, causing community infection, which...
Abstract Four indole derivatives synthesized from 2‐keto glycosides were analyzed by electrospray ionization tandem mass spectrometry (ESI‐MS n ) with low‐energy collision‐induced dissociation to establish a general structural elucidation of derivatives. Their fragmentation pathways are proposed on the basis MS studies and deuterium‐labeled experiments. Indole undergo complicated gas‐phase rearrangements in addition simple bond cleavages. A rearrangement, which involves contraction...
Abstract Background Previous research on monogenic IBD (m-IBD) has mainly focused very-early-onset (VEO-IBD) and Montreal classification A1 type patients. In non-A1 (age &gt; 16y) late-onset patients, some individuals also exhibit manifestations due to mutations. Here we systematically review the literature, using infantile-onset patients as a control, explore genetic characteristics, clinical presentations, treatment strategies of IBD. Methods Based onset age IBD, m-IBD was categorized...