A5016540837- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- T-cell and B-cell Immunology
- Natural product bioactivities and synthesis
- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- Autoimmune Neurological Disorders and Treatments
- RNA modifications and cancer
- Neurobiology and Insect Physiology Research
- Allergic Rhinitis and Sensitization
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Long-Term Effects of COVID-19
- CRISPR and Genetic Engineering
- Pharmacological Effects of Natural Compounds
- Viral Infections and Outbreaks Research
- Glycosylation and Glycoproteins Research
- Parkinson's Disease Mechanisms and Treatments
- Viral Infections and Vectors
- EEG and Brain-Computer Interfaces
- Cancer-related molecular mechanisms research
- Phytochemical compounds biological activities
- Heat shock proteins research
- Polyamine Metabolism and Applications
- Galectins and Cancer Biology
Air Force Medical University
2017-2025
State Key Laboratory of Food Science and Technology
2024-2025
Jiangnan University
2024-2025
Tianjin People's Hospital
2024
Jiangsu University of Science and Technology
2024
Sericultural Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
China Three Gorges University
2024
Sun Yat-sen University
2024
Tianjin Medical University
2024
Enhanced aerobic glycolysis constitutes an additional source of energy for tumor proliferation and metastasis. Human papillomavirus (HPV) infection is the main cause cervical cancer (CC); however, associated molecular mechanisms remain poorly defined, as does relationship between CC glycolysis. To investigate whether HPV 16/18 E6/E7 can enhance in CC, expression was knocked down SiHa HeLa cells using small interfering RNA (siRNA). Then, glucose uptake, lactate production, ATP levels,...
Abstract Background Alzheimer’s disease (AD) is a prevalent form of dementia leading to memory loss, reduced cognitive and linguistic abilities, decreased self-care. Current AD treatments aim relieve symptoms slow progression, but cure elusive due limited understanding the underlying mechanisms. Main content Stem cell technology has potential revolutionize research. With ability self-renew differentiate into various types, stem cells are valuable tools for modeling, drug screening, therapy....
Abstract Cervical cancer (CC) is the most common gynecologic malignancy, which seriously threatens health of women. Lipid metabolism necessary for tumor proliferation and metastasis. However, molecular mechanism relationship between CC lipid remains poorly defined. We revealed expression IGF2BP3 in exceeded adjacent tissues, was positively associated with stage using human tissue microarrays. The Cell Counting Kit-8, colony formation assay, 5-ethynyl-2′-deoxyuridine transwell assays,...
Melatonin (Mel) and its receptors (MT1 MT2) have a well-documented efficacy in treating different pain conditions. However, the anti-nociceptive effects of Mel neuropathic (NP) are poorly understood. To elucidate this process, behaviors were measured dorsal root ganglia (DRG)-friendly sciatic nerve cuffing model. We detected up-regulation MT2 expression DRGs cuff-implanted mice activation by agonist 8-M-PDOT (8MP). Also, attenuated mechanical thermal allodynia induced cuff implantation....
Incomplete immune recovery in people living with HIV/AIDS (PLWHA) remains an important clinical challenge the lack of effective strategy currently available to restore their T-cell response. This study aimed evaluate effect Albuvirtide (ABT) on immunological non-responders (INRs) and attempted explore potential mechanisms ABT functionality cells.
Purpose: To investigate the major allergen components associated with birch pollen allergy in northern China and elucidate clinical relevance to food syndrome (PFAS). Methods: Fifty-eight patients were recruited for a cross-sectional study categorized into two groups: PFAS group non-PFAS group, as well apple non-apple group. The sIgE levels of its components, namely Bet v 1, 2, 4, 6, analyzed. Results: Among 58 participants, 44 individuals (75.9%) reported PFAS. 32 out (72.7%) participants...
Tumor metastasis is the main cause of hepatocellular carcinoma (HCC) related death. Loss cell polarity may lead to weakened adhesion, epithelial-mesenchymal transition (EMT), and HCC. However, mechanism involved in HCC cells loss still less studied. Here, we found that BAP31 expression increased with tumor grade metastasis. Moreover, silencing inhibited invasion migration recovered cells. RNA-seq identified SPINK6 was a downstream gene BAP31, associated stage IP-MS IF assays showed bound RNA...
It is well demonstrated that immunosuppressants can reduce, but not eliminate the risk of generalized development in ocular myasthenia gravis (OMG). In this study, we aimed to explore predictive factors conversion OMG patients who received immunosuppressive treatments.OMG under treatments Tangdu Hospital from June 2008 2012 were retrospectively reviewed. Baseline clinical characteristics documented. Patients followed up regularly by face-to-face interview and main outcome measure was...
Guillain-Barré Syndrome (GBS), characterized by peripheral nerve demyelination and axonal damage, is initiated aggravated through various of immunopathogenesis. Ginsenoside Rd, main active components extracted from ginseng saponins, known to exhibit immune-regulate functions in many immune-mediated diseases. However, the evidence preventive effect Rd on GBS lacking. Experimental autoimmune neuritis (EAN) mice, classic model GBS, were established treated with GSRd or vehicle. Clinical score...
Abstract Background The crosstalk between the ubiquitin‐proteasome and immune system plays an important role in health pathogenesis of viral infection. However, there have been few studies ubiquitin activation severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Methods We investigated effect ubiquitination on SARS‐CoV‐2 infection patient prognosis by integrating published disease 2019 (COVID‐19) multi‐transcriptome data bioinformatics methods. Results differential expression...
Background Cognitive function impairment (CFI) and the Composite Dietary Antioxidant Index (CDAI) were investigated in this study. Methods Participants from 2011–2014 cycles of National Health Nutrition Examination Survey chosen to assess cognitive using Consortium Establish a Registry for Alzheimer’s Disease Word Learning Test, Animal Fluency Digit Symbol Substitution Test. scored below 25% percentile any three tests defined as having impairment. 24-h recalls diet collected calculate CDAI....
<title>Abstract</title> Hemorrhagic fever with renal syndrome (HFRS) occurs throughout Eurasia considerable morbidity and mortality. Currently, the absence of specific treatments or effective antiviral drugs for hantavirus infection makes developing safe vaccines a high priority. Here, we report development three novel nucleic acid vaccine candidates, mRNA, DNA, DNA encapsulated in lipid nanoparticles, encoding glycoproteins Hantaan virus (HTNV). To comprehensively evaluate potential...