A5074143068- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- COVID-19 diagnosis using AI
- Nanoplatforms for cancer theranostics
- Cardiac Valve Diseases and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Bladder and Urothelial Cancer Treatments
- Photodynamic Therapy Research Studies
- Cancer, Hypoxia, and Metabolism
- Aortic Disease and Treatment Approaches
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- Advanced Neuroimaging Techniques and Applications
- Breast Cancer Treatment Studies
- Brain Tumor Detection and Classification
- Cardiovascular Function and Risk Factors
- Gastric Cancer Management and Outcomes
- Urinary and Genital Oncology Studies
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Acute Kidney Injury Research
- Advanced Neural Network Applications
- Colorectal and Anal Carcinomas
Wuhan National Laboratory for Optoelectronics
2024
Huazhong University of Science and Technology
2024
Chinese PLA General Hospital
2023-2024
Chinese General Hospital College of Nursing and Liberal Arts
2023
Chinese People's Liberation Army
2021-2023
PLA Academy of Military Science
2022-2023
Chinese People’s Liberation Army 263 hospital
2023
Wuhan Institute of Virology
1985
Introduction: Currently, the incidence of liver cancer is on rise annually. Precise identification tumors crucial for clinicians to strategize treatment and combat cancer. Thus far, tumor contours have been derived through labor-intensive subjective manual labeling. Computers gained widespread application in realm segmentation. Nonetheless, segmentation remains a formidable challenge owing diverse range volumes, shapes, image intensities encountered. Methods: In this article, we introduce an...
We developed machine learning models that combine preoperative and intraoperative risk factors to predict mortality after cardiac surgery.Machine involving random forest, neural network, support vector machine, gradient boosting was compared with the scores of EuroSCORE I II, Society Thoracic Surgeons (STS), as well a logistic regression model. Clinical data were collected from patients undergoing adult surgery at First Medical Centre Chinese PLA General Hospital between December 2008 2017....
. Radiation therapy (RT) represents a prevalent therapeutic modality for head and neck (H&N) cancer. A crucial phase in RT planning involves the precise delineation of organs-at-risks (OARs), employing computed tomography (CT) scans. Nevertheless, manual OARs is labor-intensive process, necessitating individual scrutiny each CT image slice, not to mention that standard scan comprises hundreds such slices. Furthermore, there significant domain shift between different institutions' H&N data,...
Abstract Background Triple‐negative breast cancer (TNBC) is the most aggressive type of cancer. Immune checkpoint inhibitors (ICIs) have been widely used to treat various tumors and changed landscape tumor management, but data from real‐world studies ICIs for TNBC treatment remain limited. The aim this study was evaluate efficacy in patients with advanced a setting explore possible correlates. Methods clinical who received ICI Chinese People's Liberation Army (PLA) General Hospital were...
Immunotherapy has transformed cancer treatment patterns for advanced hepatocellular carcinoma (aHCC) in recent years. Therefore, the identification of predictive biomarkers important clinical implications.We collected medical records from 117 aHCC patients treated with anti-PD-1 antibody. Kaplan-Meier analysis and Cox proportional hazard regression were used to evaluate association between peripheral blood overall survival (OS) progression-free (PFS). Finally, prognostic nomogram was...
Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a major complication that results in short- and long-term mortality among patients. Here, we adopted machine learning algorithms to build prediction models with the overarching goal of identifying patients who are at high risk such unfavorable outcomes. Methods: A total 1686 (development cohort) 422 (validation cohort), 126 pre- intra-operative variables, were recruited from First Medical Centre Sixth Chinese PLA General...
Recurrent metastasis after radical resection in patients of colorectal cancer (CRC) is a great challenge for the world, which genomic alterations play major role tumorigenesis. MUC4 plays significant recurrence and tumor. This study aimed at exploring association between variants metastatic CRC.Forty-seven relapsing with 37 remaining disease-free postoperatively were enrolled. Next-generation sequencing (NGS) detected mutations. Mutation mRNA expression data downloaded from TCGA cBioPortal...
Combination therapy with immune checkpoint inhibitors (ICIs) and antiangiogenic agents is generally effective well tolerated might be for metastatic urothelial carcinoma (UC). However, ICI treatment often associated unique responses, such as pseudoprogression ICI-related pneumonitis (CIP), which may influence clinical decision making affect treatment. Although there have been many studies on the mechanism of CIP, characteristics relationship these special events in a setting remain rarely...
e13090 Background: Triple-negative breast cancer (TNBC) is the most aggressive type of cancer. The lack specific targets leads in fewer effective treatments and poor prognosis. Immunotherapy has become a new generation treatment approach addition to surgery, radiotherapy, chemotherapy, endocrine therapy targeted therapy. Immune checkpoint inhibitors (ICIs) have been widely used clinical various tumors changed landscape tumor treatment, but data from real-world studies ICIs for TNBC remain...
Hepatic ischemia-reperfusion (I/R) injury is the main cause of morbidity and mortality after hepatectomy; thus, new methods for reducing I/R are required. The aim this study to evaluate changes in average apparent diffusion coefficient (ADCavg) fractional anisotropy (FA) rabbits with partial hepatic magnetic resonance tensor imaging (DTI).The left lobe rabbit liver underwent 60 minutes ischemia followed by 0.5, 2, 6, 12, 24, 48 hours reperfusion. T2-weighted images (T2WI), T1-weighted...
Purpose: This study aims to investigate the process of small cell lung cancer (SCLC) patients from achieving optimal efficacy experiencing disease progression until death. It examines predictive value treatment response on free survival (PFS) and overall (OS) SCLC patients. Patients Methods: We conducted a retrospective analysis 136 diagnosed 1992 2018. Important prognostic factors were identified construct nomogram models. The performance models was evaluated using receiver operating...
Pancreatic ductal adenocarcinoma (PDAC) is in urgent need of a second-line or later-line treatment strategy. We aimed to analyze the efficacy and safety additional anlotinib, specifically anlotinib combination with immunotherapy, patients PDAC who have failed first-line therapy.
Abstract The authors report histopathologic effect of preoperative chemotherapy using 5‐Fu fat emulsion for a series 42 cases gastric carcinoma. To each patient 348–464 mg was given orally every day 10 days before operation. It well tolerated and no apparent side‐effects were encountered. overall response rate 57.14%. We hold that this regimen is beneficial cancer.
Abstract Background: Immunotherapy has transformed cancer treatment patterns for advanced hepatocellular carcinoma (aHCC) in recent years. Therefore, the identification of predictive biomarkers important clinical implications. Methods: We collected medical records from 117 aHCC patients treated with anti-PD-1 antibody. Kaplan-Meier analysis and Cox proportional hazard regression were used to evaluate association between peripheral blood overall survival (OS) progression-free (PFS). Finally,...
Photodynamic therapy (PDT) has limited effects in treating metastatic breast cancer. Immune checkpoints can deplete the function of immune cells; however, expression after PDT is unclear. This study investigates whether efficacy due to upregulated and tries combine checkpoint inhibitor observe efficacy. A cancer model was treated by mediated hematoporphyrin derivatives (HpD-PDT). The anti-tumor effect HpD-PDT observed, as well CD4[Formula: see text]T, CD8[Formula: text]T calreticulin (CRT)...
Abstract Purpose: A definition of human epidermal growth factor receptor-2 (HER2)-low was recently proposed with the development novel antibody-drug conjugates (ADCs). Current studies on HER2-low are associated metastatic breast cancer (BC), and less is known about early stage BC. Hence, a retrospective study conducted based BC to comprehensively analyze its clinicopathological features prognostic roles compared HER2 immunohistology(IHC) 0. Method: Patients HER2-negative (N = 999) diagnosed...