A5061040155- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Vibrio bacteria research studies
- Renal cell carcinoma treatment
- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- Head and Neck Cancer Studies
- Renal and related cancers
- Malaria Research and Control
- Biosimilars and Bioanalytical Methods
- Platelet Disorders and Treatments
- vaccines and immunoinformatics approaches
- Climate Change and Health Impacts
- Economic and Financial Impacts of Cancer
- Heparin-Induced Thrombocytopenia and Thrombosis
- Lung Cancer Treatments and Mutations
- Immune responses and vaccinations
- Thermal Regulation in Medicine
- Vaccine Coverage and Hesitancy
- Biotechnology and Related Fields
- Zoonotic diseases and public health
- Immunotherapy and Immune Responses
- Lung Cancer Diagnosis and Treatment
- Intramuscular injections and effects
Fundação Oswaldo Cruz
2017-2024
Instituto Nacional do Câncer
2013-2016
In 2009, Bio-Manguinhos conducted a dose-response study with the yellow fever vaccine, administering vaccine in usual mean dose of 27,476 IU (full dose, reference) and tapered doses (10,447 IU, 3013 587 158 31 IU) by subcutaneous route volume (0.5 mL). Tapered were obtained dilution manufacturer's laboratory, test batches presented industrial quality. Doses down to showed similar immunogenicity full (27,476, reference), while displayed lower immunogenicity. Seropositivity was maintained at...
In 2013, the World Health Organization (WHO) withdrew recommendation of booster doses yellow fever (YF) vaccine, based on retrospective and cross-sectional studies that showed lifelong protective immunity from a single dose. Currently, transmission in Brazil occurs only through jungle (sylvatic) cycle. However, high vector density Aedes aegypti , which transmits other orthoflaviviruses, is concern for expansion YF regions country. We conducted cohort study to assess duration vaccine-induced...
The present study aims to determine whether 17DD-YF-specific humoral and cellular immunological memory is maintained 8-years after primary vaccination with subdoses (10,447IU;3,013IU;587IU;158IU;31IU). Our results demonstrated that vaccinees, who had seroconverted following not been revaccinated, similar neutralizing antibodies levels YF-specific memory, particularly CMCD4 EMCD8 as compared the reference full dose (27,476IU). Although, PRNT seropositivity rates were across subgroups...
Essentials•New variants of SARS-CoV-2 led to the administration booster vaccines against COVID-19.•Vaccine-induced immune thrombotic thrombocytopenia (VITT) was recently reported in Brazil.•We describe 15 cases suspected VITT after third and fourth doses COVID-19 vaccine.•The estimated frequency ChAdOx1 0.33 per million.AbstractBackgroundThe emergence new has different mitigate COVID-19. Vaccines with adenoviral vectors have been rarely associated vaccine-induced (VITT).ObjectivesThis study...
The aim of this study was to assess the impact sunitinib treatment in a non-screened group patients with metastatic renal cell cancer (mRCC) treated by Brazilian Unified Health System (SUS) at single reference institution.Retrospective cohort study, which evaluated mRCC who received between May 2010 and December 2013.Fifty-eight were eligible. Most male 41 (71%), median age 58 years. Nephrectomy performed (71%) interval 16 months surgery initiation sunitinib. most prevalent histological...
A single dose of standard yellow fever (YF) vaccine is considered to provide life-long protection. In this study, we evaluate the seropositivity conferred by lower doses 10 years post-vaccination. 2009, Bio-Manguinhos/Fiocruz performed a dose-response study with 17DD vaccine, administering in usual mean 27.476 IU and decreasing (10.447 IU, 3.013 587 158 31 IU), volume route (0,5 ml subcutaneous). The were obtained dilution laboratory manufacturer lots test had quality control produced good...
In response to the coronavirus disease 2019 (Covid-19) pandemic, Brazil authorised Astra Zeneca/Fiocruz vaccine in January 2021. As Delta variant emerged May 2021, interval between doses was adjusted. By September Brazilian National Immunisation Program recommended a booster dose for individuals over 70, and later expanded recommendation all adults.
Introduction:The problem of inadequate supply yellow fever vaccine (YFV) is recurrent, due to a combination limited production capacity and expansion circulation the virus.In 2009 Bio-Manguinhos did dose-response study with YFV, administrated in usual mean dose 27,476 IU decreasing doses (10,447 IU, 3013 587 158 31 IU), by subcutaneous route volume (0.5mL).The were obtained dilution laboratory manufacturer lots test had industrial quality.Around 30 days after vaccination, down similar...
Introduction: Yellow fever is an acute febrile illness caused by the Fever Virus, which mainly transmitted mosquito bites in tropical and subtropical areas of Africa South America.The change epidemiology, risks urban outbreaks international spread, consequent intermittent epidemics with significant morbidity mortality rates, represent emerging threat to Global Health.Vaccination remains best strategy eliminate yellow fever.However, we eventually face falls coverage indicators lack access...