A5100762298- Diabetes Management and Research
- RNA modifications and cancer
- Metallic Glasses and Amorphous Alloys
- SARS-CoV-2 and COVID-19 Research
- Stress Responses and Cortisol
- COVID-19 Clinical Research Studies
- Retinal and Macular Surgery
- Reading and Literacy Development
- Glass properties and applications
- Cognitive and developmental aspects of mathematical skills
- Circadian rhythm and melatonin
- Neuroendocrine regulation and behavior
- CAR-T cell therapy research
- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Corneal Surgery and Treatments
- Intraocular Surgery and Lenses
- Advanced Neuroimaging Techniques and Applications
- Phase-change materials and chalcogenides
- Environmental remediation with nanomaterials
- Preterm Birth and Chorioamnionitis
- Plasma Applications and Diagnostics
- MicroRNA in disease regulation
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Disease and Adiposity
Hangzhou Medical College
2024-2025
Zhejiang Provincial People's Hospital
2024-2025
Nanjing University of Chinese Medicine
2024-2025
Jiangsu Province Hospital
2025
University of Science and Technology of China
2025
Zhejiang Chinese Medical University
2024
Southeast University
2024
Sechenov University
2024
Nanjing University
2021-2024
Nanjing General Hospital of Nanjing Military Command
2021-2024
Chimeric antigen receptor (CAR) T cell therapy faces a number of challenges for the treatment non-small-cell lung carcinoma (NSCLC), and efficient migration circulating CAR cells plays an important role in anti-tumor activity. In this study, specific tumor mesothelin (Msln-CAR) was co-expressed with chemokine receptors CCR2b or CCR4. Findings showed that CCR4 enhanced Msln-CAR vitro by transwell assay. When incubated mesothelin-positive cells, Msln-CCR2b-CAR Msln-CCR4-CAR specifically...
COVID-19 pandemic caused by SARS-CoV-2 infection severely threatens global health and economic development. No effective antiviral drug is currently available to treat any other human coronavirus infections. We report herein that a macrolide antibiotic, carrimycin, potently inhibited the cytopathic effects (CPE) reduced levels of viral protein RNA in multiple cell types infected 229E, OC43, SARS-CoV-2. Time-of-addition pseudotype virus studies indicated carrimycin one or post-entry...
Abstract Non-invasive brain stimulation therapy for autism spectrum disorder (ASD) has shown beneficial effects. Recently, we and others demonstrated that visual sensory using rhythmic 40 Hz light flicker effectively improved cognitive deficits in mouse models of Alzheimer’s disease stroke. However, whether can ameliorate behavioral ASD remains unknown. Here, show 16p11.2 deletion female mice exhibit a strong social novelty deficit, which was ameliorated by treatment with long-term...
BACKGROUND The duodenum plays a significant role in metabolic regulation, and thickened mucous membranes are associated with insulin resistance. Duodenal mucosal resurfacing (DMR), new-style endoscopic procedure using hydrothermal energy to ablate this layer, shows promise for enhancing glucose lipid metabolism type 2 diabetes (T2D) patients. However, the mechanisms driving these improvements remain largely unexplored. AIM To investigate by which DMR improves disorders rat model. METHODS...
Alumina-based ceramic composites are widely used for cutting tools owing to their high strength and oxidation resistance. However, brittle nature low toughness adversely affect use performance. In this study, alumina/silicon carbide (Al2O3/SiC) with different mass fractions of Ni (5 %, 10 15 20 %) were prepared via vacuum hot-press sintering optimise toughness. The structural mechanical properties the characterised using various techniques. hardness bending Ni-doped Al2O3/SiC increased...
Abstract Homologous recombination repair (HRR) is crucial for maintaining genomic stability by repairing DNA damage. Despite its importance, HRR's role in cancer progression not fully elucidated. Here, this work shows that nuclear‐localized branched‐chain α‐ketoacid dehydrogenase kinase (BCKDK) acts as a modulator of HRR, promoting cell resistance against damage‐inducing therapy breast cancer. Mechanistically, demonstrates BCKDK localized the nucleus and phosphorylates RNF8 at Ser157,...
As a CGM-derived indicator, 'time in range' (TIR) is emerging as key indicator for accurate assessment of glycaemic control. However, there few report focusing on the correlation TIR with albumuria and renal fuction. The aim this work was to investigate whether TIR, well nocturnal hypoglycaemic events related presence severity albuminuria decrease eGFR type 2 diabetes.A total 823 patients were enrolled study. All received continuous glucose monitoring, indicating percentage time that blood...
Abstract Phonological awareness (PA) is an important predictor and outcome of reading. Yet, little known about the reciprocal relation between PA reading across development without consistent experience (e.g., as a result limited access to quality education late enrolment in school). We tested hypothesis that variable childhood influences neural activation regions involved language processing—left frontal temporoparietal cortex. Sixty‐nine primary‐school children ( M age = 10.4) from rural...
Recent studies suggested that the rich club organization promoting global brain communication and integration of information, may be abnormally increased in obsessive-compulsive disorder (OCD). However, structural functional basis this is still not very clear. Given heritability OCD, as by previous family-based studies, we hypothesize aberrant a trait marker for OCD. In present study, 32 patients with 30 unaffected first-degree relatives (FDR) healthy controls (HC) underwent diffusion tensor...
Time in range (TIR) is advocated as key metric of glycemic control and reported to be associated with microvascular complications diabetes. Sudomotor dysfunction among the earliest detectable diabetic peripheral neuropathy (DPN). We set about research relationship between TIR including overnight sudomotor function detected by SUDOSCAN intention exploring correlation early DPN type 1 diabetes (T1D).
In this study, the effects of discontinuous precipitation, a process known to enhance mechanical properties in alloys, on microstructure and (FeCoNi) 86 Al 7 Ti high‐entropy alloy (HEA) are investigated. Varying aging temperatures leads formation lamellar structures consisting face‐centered cubic (FCC) body‐centered phases, which significantly influence alloy. The treatments reveal an inverse relationship between temperature microhardness, with values decreasing from 890 700 HV as rises 550...
Objective Impaired interhemispheric connectivity and corpus callosum atrophy have been linked to cognitive impairment in Alzheimer’s disease (AD). Existing evidence indicates that repetitive transcranial magnetic stimulation (rTMS) targeting the bilateral precuneus may enhance function AD. This study aims investigate effects of rTMS on function, as well alterations functional (FC) its structural basis patients with subjective decline (SCD) mild (MCI). Methods A total 14 SCD 16 MCI were...
Phonological awareness (PA) is an important predictor and outcome of reading. Yet, little known about the reciprocal relation between PA reading across development without consistent experience (e.g., due to limited access quality education late enrolment in school). We tested hypothesis that variable childhood influences neural activation regions involved language processing—left frontal temporoparietal cortex. Sixty-nine primary-school children (Mage=10.4) from rural low-literacy...
<title>Abstract</title> Non-invasive brain stimulation therapy for autism spectrum disorder (ASD) has shown beneficial effects. Recently, visual sensory using rhythmic 40 Hz light flicker effectively improved cognitive deficits in mouse models of Alzheimer's disease and stroke. However, whether can ameliorate behavioral ASD remains unknown. Here, we show that 16p11.2<sup>+/−</sup> female mice exhibit a strong social novelty deficit, which was ameliorated by treatment with long-term...
Recent studies have introduced the weight-adjusted waist circumference index (WWI) as a viable obesity indicator that may better reflect centripetal and its associated risks. In examining connection between WWI prostate-specific antigen (PSA), this study leveraged data from National Health Nutrition Examination Survey 2003-2010, including 5732 participants. Our initial analysis indicated significant positive association PSA levels. However, subsequent models adjusted for covariates such age,...
To investigate the effects of elesclomol-Cu (ES-Cu) on proliferation and cuproptosis human acute myeloid leukemia (AML) cells.