Gan Sha

ORCID: 0009-0008-1966-8656
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About
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Research Areas
  • Plant-Microbe Interactions and Immunity
  • Photosynthetic Processes and Mechanisms
  • Plant biochemistry and biosynthesis
  • CRISPR and Genetic Engineering
  • Microbial Natural Products and Biosynthesis
  • Legume Nitrogen Fixing Symbiosis
  • Plant Gene Expression Analysis
  • Plant Stress Responses and Tolerance
  • Fungal and yeast genetics research
  • Plant Virus Research Studies
  • Power Systems and Technologies
  • Weed Control and Herbicide Applications
  • Antimicrobial Peptides and Activities
  • Nanoparticles: synthesis and applications
  • Autophagy in Disease and Therapy
  • Service-Oriented Architecture and Web Services
  • Evolution and Genetic Dynamics
  • Polysaccharides and Plant Cell Walls
  • Insect-Plant Interactions and Control
  • Probiotics and Fermented Foods
  • Advanced Computational Techniques and Applications
  • Biochemical and Structural Characterization

Huazhong Agricultural University
2022-2025

South China Agricultural University
2024-2025

State Key Laboratory of Agricultural Microbiology
2022

As with the majority of hemibiotrophic fungal pathogens, rice blast fungus Magnaporthe oryzae uses highly specialized infection structures called appressoria for plant penetration. Appressoria differentiated from germ tubes rely on enormous turgor pressure to directly penetrate cell, in which process lipid metabolism plays a critical role. In this study, we characterized MoPAH1 gene M. oryzae, encoding putative conserved phosphatidate phosphatase. The expression was up-regulated during...

10.1111/mpp.13193 article EN Molecular Plant Pathology 2022-02-21

The widely used rice variety Lijiangxintuanheigu (LTH) shows a universal susceptibility to thousands of Magnaporthe oryzae isolates, the causal agent devastating blast, making LTH an ideal line in resistance (R) gene cloning. However, underlying genetic mechanism has not been fully revealed because lack high-quality genome. Here, we took genomic approach together with experimental assays investigate LTH's blast. Using Nanopore long reads, assembled chromosome-level Millions variants were...

10.1016/j.csbj.2022.01.030 article EN cc-by Computational and Structural Biotechnology Journal 2022-01-01

Phosphatidic acid (PA) functions as a cell membrane component and signaling molecule in plants. PA metabolism has multiple routes, one of which is converted into cytidine diphosphate diacylglycerol (CDP-DAG) by CDP-DAG synthases (CDSs). CDS genes are highly conserved Here, we found that knock-down the gene enhanced resistance Arabidopsis thaliana to pathogens, with growth penalty. When leaves were treated chitin or flg22, reactive oxygen species (ROS) production cds mutants was significantly...

10.1101/2025.01.24.634677 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2025-01-27

Phosphatidic acid (PA) functions as a cell membrane component and signaling molecule in plants. PA metabolism has multiple routes, one of which is converted into cytidine diphosphate diacylglycerol (CDP-DAG) by CDP-DAG synthases (CDSs). CDS genes are highly conserved Here, we found that knock-down the gene enhanced resistance Arabidopsis thaliana to pathogens, with growth penalty. When leaves were treated chitin or flg22, reactive oxygen species (ROS) production cds mutants was significantly...

10.1080/15592324.2025.2471503 article EN cc-by-nc Plant Signaling & Behavior 2025-02-25

10.1016/j.tim.2023.09.007 article EN Trends in Microbiology 2023-09-29

Plant pathogens cause devastating diseases, leading to serious losses agriculture. Mechanistic understanding of pathogenesis plant lays the foundation for development fungicides disease control. Mitophagy, a specific form autophagy, is important fungal virulence. The role cardiolipin, mitochondrial signature phospholipid, in mitophagy and largely unknown pathogenic fungi. functions enzymes involved cardiolipin biosynthesis relevant inhibitors were assessed using set assays, including genetic...

10.1111/pce.15021 article EN Plant Cell & Environment 2024-07-01

Phosphatidic acid (PA) is considered as a second messenger that interacts with protein kinases, phosphatases and NADPH oxidases, amplifying the signal to initiate plant defense signaling responses (Li Wang, 2019). In rice, mutation of RBL1 causes accumulation PA, enhancing multipathogen resistance (Sha et al., 2023). our previous study, we attempted rescue rbl1 mutant by overexpressing phosphatidate phosphohydrolase ( PAH ) genes. However, overexpression PAH2 reduced PA level but did not...

10.1101/2024.07.04.602136 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-07-08

This study addresses the critical need for new antibacterial drugs in face of bacterial multidrug resistance resulting from antibiotic overuse. It highlights significance antimicrobial peptides as essential components innate immunity animals and plants, which have been proven effective against multidrug-resistant bacteria are difficult to develop against. successfully synthesizes a broad-spectrum peptide, BsR1, with strong inhibitory activities various Gram-positive Gram-negative bacteria....

10.1128/spectrum.02578-23 article EN cc-by Microbiology Spectrum 2023-11-10

Abstract Plant pathogens cause devastating diseases, leading to serious losses agriculture. Mechanistic understanding of pathogenesis plant lays the foundation for development fungicides disease control. Mitophagy, a specific form autophagy, is important fungal virulence. The role cardiolipin, mitochondrial signature phospholipid, in mitophagy and largely unknown pathogenic fungi. functions enzymes involved cardiolipin biosynthesis relevant inhibitors were assessed using set assays,...

10.1101/2024.06.16.599186 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2024-06-17
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