A5113986719- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- RNA modifications and cancer
- Knee injuries and reconstruction techniques
- Orthopedic Surgery and Rehabilitation
- Drilling and Well Engineering
- Cancer, Hypoxia, and Metabolism
- RNA regulation and disease
- Tunneling and Rock Mechanics
- Sports injuries and prevention
- Orthopedic Infections and Treatments
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Lower Extremity Biomechanics and Pathologies
- Foot and Ankle Surgery
- Antimicrobial Peptides and Activities
- Cancer-related gene regulation
- Geotechnical and Geomechanical Engineering
- Tendon Structure and Treatment
- Antimicrobial agents and applications
- Virus-based gene therapy research
- Monoclonal and Polyclonal Antibodies Research
- Bone fractures and treatments
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2025
Jangan University
2025
Shenyang Sport University
2024
Northern Jiangsu People's Hospital
2020-2024
Chang'an University
2024
Bridge University
2024
Yangzhou University
2020-2023
Wuhan University of Science and Technology
2021-2022
Xijing Hospital
2021
Air Force Medical University
2020-2021
Cancer Susceptibility Candidate 9 (CASC9) is a novel gene generating long non-coding RNA (lncRNA) with oncogenic potential that was first identified in esophageal cancer. In this study, we have found CASC9 overexpressed gastric cancer (GC) compared to normal tissue. A higher expression level associated aggressive pathological characteristics, including deep invasion, poor differentiation and lymph node metastases. two cell lines, BGC823 SGC7901, were both of epithelial (GES-1). Moreover, the...
MicroRNAs (miRNAs) have been shown to be involved in the initiation and progression of glioma. However, underlying molecular mechanisms are still unclear. We performed microarray analysis evaluate miRNA expression levels 158 glioma tissue samples, examined miR-1231 samples healthy brain tissues using qRT-PCR. In vitro analyses were mimics, inhibitors, siRNA targeting EGFR. used flow cytometry, CCK-8 assays, colony formation assays examine proliferation cell cycle analysis. A dual luciferase...
A growing body of evidence implicates aberrant expression microRNAs (miRNAs) and dysregulation mRNA translation in the development growth cancer cells. However, little is known about mechanisms action miRNAs glioma, most common form adult‑onset malignant brain tumor. In present study, function miR‑767‑5p were examined human glioblastoma multiforme (GBM) tissue specimens cell lines. levels analyzed by quantitative reverse‑transcription PCR; proliferation was assessed CCK‑8, colony formation...
Glioma is considered one of the most common tumors and has a poor prognosis. Recently, microRNAs (miRNAs) have been reported to be strongly linked various human including glioma. In this study, we investigated new anticancer miRNA, miR-346, determine effects mechanism miR-346 its downstream target gene NFIB on tumors.Lentivirus transfection, real-time PCR, western blotting, immunohistochemistry, cell proliferation assays, mouse experiments were used examine relationship between regulation in...
To address the issue of performance testing hydraulic rock drills under specific working conditions, a stiffness–damping multi-stage adjustable simulation system has been proposed. Firstly, based on Kelvin theory, vibration model nonharmonic excitation is established. An integer-order created fluid mechanics theory. The characteristics granite and are studied, discussing influencing factors characteristics. Next, drop hammer calibration experiment an impact drilling for designed. Finally, in...
This study investigates the effect of Shenqi Shenkang granule (SQSKG) on chronic kidney disease (CKD), focusing regulating PI3K/AKT/mTOR pathway, autophagy, and mitochondrial homeostasis. The compounds targets SQSKG CKD were identified by network pharmacology validated molecular docking. LC-MS/MS was used to verify screened pharmacology. In vitro experiments based HK-2 cells assess its impact cell migration, viability, oxidative stress, key proteins fibrosis. Mitochondrial function...
Abstract Background Tendon adhesion is one of the most common clinical problems, which poses a considerable challenge to orthopedics doctors. Quercetin (QUE) as popular drug at present, it has various biological functions, including anti-inflammatory, anti-ischemic, anti-peroxidation, and antioxidant. The purpose this study was investigate effect quercetin on tendon whether can inhibit oxidative stress. Method Thirty-six rats were randomly divided into three groups, control group, low QUE...
Osteosarcoma (OS) is a primary malignant bone tumor, and the cure rate has stagnated in past three decades. Butein, plant polyphenol extracted from many herbs, been proved to possess anti-tumor activity. However, effect of butein on human OS underlying mechanisms remain be elucidated.The cell line 143B was used. The effects were evaluated through proliferation assay, flow cytometry, florescence transmission electron microscopy, western blotting. All statistical analyses performed using...
Glioma accounts for the majority of primary malignant brain tumors in adults and is highly aggressive. Although various therapeutic approaches have been applied, outcomes glioma treatment remain poor. MicroRNAs are a class small noncoding RNAs that function as regulators gene expression. Accumulating evidence shows microRNAs associated with tumorigenesis tumor progression. In this study, we found miR-105 significantly downregulated tissues cell lines. We identified suppressor Zeste 12...
Previous studies have demonstrated that long non‑coding RNAs (lncRNAs) serve a key role in the development and progression of several types cancer, including glioma. The lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) contributes to cancer growth through its effects on cell proliferation, migration, invasion drug resistance. However, exact regulatory mechanisms via which NEAT1 acts glioma are unclear. In present study, expression levels function tissues lines were examined <em>in...
Osteosarcoma (OS) is the most common primary malignant tumor in children and adolescents. Numerous studies have reported importance of miRNA OS. The purpose this study to predict potential biomarkers new therapeutic targets for OS diagnosis prognosis by analyzing miRNAs plasma samples from Gene Expression Omnibus (GEO) database.Data-sets were downloaded GEO analyzed using R software. Different expressions (DE-miRNAs) mRNAs (DE-mRNAs) patients identified. Funrich was used transcription...
Background: It is widely acknowledged that pathogenic germs delay wound healing to some extent. To explore factors influencing the process, current study was conducted evaluate antibacterial effect of topical application copper sulfide nanoparticles (CuS NPs) in vitro and on infected process rat model. Materials Methods: In this study, morphology size CuS NPs were detected. Staphylococcus aureus Escherichia coli used so ability could be evaluated better. addition, a 2-cm circular...
Osteoporosis is the most common skeletal disease characterized by an imbalance between bone resorption and remodeling. can lead to loss microstructural deterioration. This increases risk of fragility fracture, severely reducing patients’ mobility quality life. However, specific molecular mechanisms involved in development osteoporosis remain unclear. Increasing evidence suggests that multiple noncoding RNAs show differential expression state. Meanwhile, have been associated with increased...
Abstract Purpose Osteosarcoma (OS) is a differentiation disease caused by the genetic and epigenetic of mesenchymal stem cells into osteoblasts. OS common, highly malignant tumor in children adolescents. Fifteen to 20 % patients find distant metastases at their first visit. The purpose our study was identify biomarkers for tracking prognosis treatment improve survival rate patients. Materials methods In this study, which based on Therapeutically Applicable Research Generate Effective...
Background Patella fractures that require surgery are conventionally treated using Kirschner wires (K-wires) and stainless steel wires. In recent years, the nonabsorbable polyester has been reported to have excellent outcomes clinically. Therefore, goal of our study was evaluate effects combined with 5-Ethibond on treating patellar fractures. Methods From July 2018 January 2022, 22 patella fracture patients were 5-Ethibond. Radiographs knees used healing hardware complications. The clinical...
Purpose Infrapatellar pole fractures are challenging injuries that require appropriate treatment to ensure optimal functional outcomes. This study aimed introduce the application of Suture Bridge technique using 5-Ethibond for infrapatellar patella fracture. Methods Five cases fracture were treated at our institution between February 2020 and September 2021. The patients included one male four females, with an average age 66 years (range: 60–77 years). All preserve pole. Results operative...