A5026575127- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Childhood Cancer Survivors' Quality of Life
- Sarcoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Fungal Infections and Studies
- Bone and Joint Diseases
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- Oral health in cancer treatment
- Hemoglobinopathies and Related Disorders
- Antifungal resistance and susceptibility
- Parvovirus B19 Infection Studies
- Cytomegalovirus and herpesvirus research
- Antibiotics Pharmacokinetics and Efficacy
- Genetic and phenotypic traits in livestock
- Immune Cell Function and Interaction
- Blood groups and transfusion
- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Cancer Diagnosis and Treatment
- Hair Growth and Disorders
- Neonatal Respiratory Health Research
- Chemotherapy-related skin toxicity
- Tumors and Oncological Cases
Toowoomba Hospital
2024
Leiden University
2003-2017
Leiden University Medical Center
2004-2015
University of Amsterdam
2008
Dalhousie University
1998
Centers for Disease Control and Prevention
1998
Alder Hey Children's Hospital
1991
University of Liverpool
1991
Royal Hospital for Children
1989
Michigan State University
1989
Background Mesenchymal stromal cells are employed in various different clinical settings order to modulate immune response. However, relatively little is known about the mechanisms responsible for their immunomodulatory effects, which could be influenced by both cell source and culture conditions.Design Methods We tested ability of a 5% platelet lysate-supplemented medium support isolation ex vivo expansion mesenchymal from full-term umbilical-cord blood. also investigated...
Background Granulocyte transfusion has been proposed as a bridging therapy for patients with prolonged periods of chemotherapy-induced neutropenia, who suffer from severe fungal and bacterial infections. To recover, adequate numbers granulocytes are required when the refractory to standard treatment. The aim this study was assess functional characteristics efficacy granulocyte colony-stimulating factor/dexamethasone-mobilized used transfusions.Design Methods Granulocytes leukapheresis...
Varicella zoster virus (VZV) reactivation following hematopoietic stem cell transplantation (HSCT) may cause significant morbidity and mortality. We undertook a retrospective study to determine the frequency risk factors associated with VZV reactivation, including underlying disease, use of fludarabine in high-risk leukemia chemotherapy protocols, immune status before HSCT.We studied 163 children who underwent first HSCT between 2002 2008, introduction routine prophylaxis on our unit....
Candida albicans and non-C. species are increasingly being isolated from patients in high-risk categories, most notably, those who have undergone stem cell transplantation (SCT). Identification of the presence early course transplant procedure is important, as these exhibit different sensitivities to available antifungal treatments cause mortality at rates that vary for C. albicans. Amplified fragment length polymorphism (AFLP) analysis has been shown be a reliable method reproducibly...
Hematopoietic stem cell transplantation is an effective therapy for life-threatening hematological diseases. Parents may be asked to donate hematopoietic cells their child when no compatible related or unrelated donor available.Parents donating G-CSF mobilized peripheral blood simultaneously and uniquely fulfill the dual role of caregiver ill child. The experiences both sibling donors have been extensively reported but not those parental donors.We therefore undertook a study specifically...
Abstract Background Although delayed red cell engraftment and/or hemolysis have been thoroughly documented in association with ABO incompatibility between donor and recipient patients undergoing hematopoietic stem transplantation (HSCT), there are no studies defining the general, long term clinical outcome a large group of pediatric patients. Methods We undertook retrospective single center analysis children allogeneic to determine influence donor/recipient incompatibility. Outcome was...
Pediatric myelodysplastic syndrome (MDS) is a heterogeneous disease covering spectrum ranging from aplasia (RCC) to myeloproliferation (RAEB(t)). In adult-type MDS there increasing evidence for abnormal function of the bone-marrow microenvironment. Here, we extensively studied mesenchymal stromal cells (MSCs) derived children with MDS. MSCs were expanded 17 patients (RCC: n=10 and advanced MDS: n=7) pediatric controls (n=10). No differences observed respect phenotype, differentiation...