A5102714525- Estrogen and related hormone effects
- Genomics, phytochemicals, and oxidative stress
- Effects and risks of endocrine disrupting chemicals
- Phytochemicals and Antioxidant Activities
- Computational Drug Discovery Methods
- Plant Stress Responses and Tolerance
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Adipose Tissue and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Pluripotent Stem Cells Research
- NF-κB Signaling Pathways
- Biological Activity of Diterpenoids and Biflavonoids
- Bioactive natural compounds
- Free Radicals and Antioxidants
- Stress Responses and Cortisol
- PARP inhibition in cancer therapy
- RNA Interference and Gene Delivery
- Steroid Chemistry and Biochemistry
- Hormonal and reproductive studies
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Physiological and biochemical adaptations
- Sirtuins and Resveratrol in Medicine
- Natural product bioactivities and synthesis
Jilin Academy of Agricultural Sciences
2019-2025
Nanjing Medical University
2015-2025
Jilin University
2023
Tianjin Medical University
2009
Tianjin Medical University General Hospital
2009
Numerous studies have reported that tangeretin is a polymethoxylated flavone with variety of biological activates, but little research has been done on the antioxidant mechanism tangeretin. Hence, we investigated effect nuclear factor erythroid 2-related 2 (Nrf2)/antioxidant response element (ARE) pathway and its potential molecular mechanisms by in vitro silico research. The results docking suggested bound at top central pore Kelch-like ECH-associated protein 1 (Keap1) Kelch domain,...
Background: A proliferation-inducing ligand (APRIL) is a tumor-necrosis factor (TNF) family member and novel cytokine crucial in sustaining lymphocytic leukemia B cell survival proliferation. However, its role gastric cancer (GC) remains unclear. In this study, we investigated the expression pattern prognostic of APRIL GC. Methods: Expression was assessed by immunohistochemistry real-time PCR. Prognostic evaluated. We also discovered effect on chemo-resistance GC cells underlying mechanisms....
ABSTRACT As natural furocoumarins, psoralen and its isomer isopsoralen are widely distributed in various fruits including Ficus carica L., vegetables celery, medicinal herbs Psoralea corylifolia L. Although have been used as dietary supplements because of their bioactivities such antibacterial anti‐inflammatory properties; however, the potential mechanisms underlying antioxidant activities these two furocoumarins still need to be explored. Hence, aims this work were examine activation...
Ablation is one of the main methods for local treatment hepatocellular carcinoma (HCC). Different from radiofrequency ablation (RFA), microwave (MWA) not limited by tissue conductivity, and can use multiple electrodes at same time to improve efficiency. In addition, MWA form a larger area, which makes it possible completely ablate large HCC. However, may be incomplete due factors such as tumors or in high-risk areas. The mechanism cellular tumor immune microenvironment (TIME) involved vitro...
This study was conducted to determine the endocrine-disrupting effects of phthalate esters (PAEs) on glucocorticoid receptor (GR) signaling. Potential (anti)glucocorticoid activities six typical PAEs including di (2-ethylhexyl) (DEHP), diisononyl (DINP), dibutyl (DBP), diisobutyl (DIBP), diethyl (DEP) and dimethyl (DMP) were evaluated human GR using cell viability assessment, reporter gene expression analysis, mRNA molecular docking simulation. For all tested chemicals, co-treatment DEHP...
Midazolam (MDZ) is an anaesthetic that widely used for anxiolysis and sedation. More recently, MDZ has also been described to be related the outcome of various types carcinomas. However, how influences progression hepatocellular carcinoma (HCC) its effects on biological function tumour immune microenvironment this type remain unknown.The proliferation, invasion, migration HCC cell lines were examined in vitro using Cell Counting Kit 8 (CCK8), 5-ethynyl-2'-deoxyuridine (EdU), Transwell, wound...
Phthalate esters (PAEs) are important pollutants in the environment, which can interfere with endocrine system by mimicking estrogen. However, limited information is available on modulating estrogen receptor (ER) of five PAEs including di (2-ethylhexyl) phthalate (DEHP), diisononyl (DINP), benzyl butyl (BBP), diphenyl (DPhP) and dicyclohexyl (DCHP). This study evaluated agonistic effects human ER. The cytotoxicity assay showed that there were a significant inhibition cell proliferation...
Background: Although glucocorticoids (GCs) are characterized as powerful agents to treat inflammatory afflictions, they accompanied by metabolic side effects which limit their usage. β-Sitosterol, a minor component found in extraction of vegetable oil, was reported have anti-inflammatory RAW 264.7 cells. Objective: To test whether β-sitosterol has an effect dissociate transrepression from transactivation selective novel GR binder, this work evaluated the dissociated characteristics...
Over the past decades, synthetic glucocorticoids (GCs) have been widely used in clinical practice and animal husbandry. Given health hazard of these toxic residues food, it is necessary to explore detailed interaction mechanisms typical GCs their main target glucocorticoid receptor (GR). Hence, this work compared GR binding agonist activities GCs. Fluorescence polarization assay showed that were potent ligands GR. Their affinities order...
Objective To optimize the transfecfion parameters for transfecting small interfering RNA (siR-NA) to endothelium of mouse angioma (EOMA) cells mediated by lentiviral vector. Methods According Poly-brene existing or not(8 μg/ml), series multiplicity infection (MOI) (1, 5, 10, 15, 20)and time infec-tion(4, 6, 12,24 h), EOMA were divided into 40 groups. 140 hours after transfection, counted un-der fluorescent microscope determine percentage transfected under each condition. The cell viability...