A5106484714- Protist diversity and phylogeny
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Connexins and lens biology
- Epigenetics and DNA Methylation
- Genetic Neurodegenerative Diseases
- MicroRNA in disease regulation
- Enzyme Production and Characterization
- Microbial Metabolic Engineering and Bioproduction
- Seaweed-derived Bioactive Compounds
- Calpain Protease Function and Regulation
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Protein Hydrolysis and Bioactive Peptides
- Supramolecular Self-Assembly in Materials
- Yersinia bacterium, plague, ectoparasites research
- Retinoids in leukemia and cellular processes
- Bacteriophages and microbial interactions
- Hydrogels: synthesis, properties, applications
- Heat shock proteins research
- Digestive system and related health
- Microbial Natural Products and Biosynthesis
- Food Industry and Aquatic Biology
Guangxi University
2023
Southern Medical University Shenzhen Hospital
2023
Beijing Children’s Hospital
2021
Capital Medical University
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2019
Peking Union Medical College Hospital
2011-2019
State Key Laboratory of Microbial Technology
2003-2015
Shandong University
2002-2015
Chinese People's Armed Police General Hospital
2011-2014
Chinese People's Armed Police Force
2011-2012
Abstract Complex environmental conditions can significantly affect bacterial genome size by unknown mechanisms. The So0157-2 strain of Sorangium cellulosum is an alkaline-adaptive epothilone producer that grows across a wide pH range. Here, we show the this 14,782,125 base pairs, 1.75-megabases larger than largest from S. reported previously. total 11,599 coding sequences (CDSs) include massive duplications and horizontally transferred genes, regulated lots protein kinases, sigma factors...
Background BMI-1 is a member of the polycomb group genes (PcGs), and it has been implicated in development progression several malignancies, but its role osteosarcoma remains to be elucidated. Methodology/Principal Findings In present study, we found that was overexpressed different types osteosarcomas. Downregulation by lentivirus mediated RNA interference (RNAi) significantly impaired cell viability colony formation vitro tumorigenesis vivo cells. knockdown sensitized cells...
Myxococcus fulvus HW-1 (ATCC BAA-855) is a halotolerant marine myxobacterium. This strain exhibits complex social behaviors in the presence of low concentrations seawater but adopts an asocial living pattern under oceanic conditions. The whole genome M. will enable us to further investigate details its evolution.
The gene encoding the GroEL chaperonin is duplicated in nearly 30% of bacterial genomes; and although groEL genes have been comprehensively determined to distinct physiological functions different species, mechanisms involved not characterized date. Myxococcus xanthus DK1622 has two copies gene, each which can be deleted without affecting cell viability; however, deletion either does result defects cellular heat-shock response, predation, development. In this study, we show that, from...
Recent studies revealed that the modification of N7-methylguanosine (m7G) has associations with many human diseases. Effectively identifying disease-associated m7G methylation sites would provide crucial clues for disease diagnosis and treatment. Previous have developed computational methods to predict based on similarities among However, few focused influence known m7G-disease association information calculating similarity measures site disease, which potentially promotes identification...
Genome sequencing of cellulolytic myxobacterium Sorangium cellulosum reveals many open-reading frames (ORFs) encoding various degradation enzymes with low sequence similarity to those reported, but none them has been characterized. In this paper, a predicted lipase gene (lipA) was cloned from S. strain So0157-2 and lipA is 981-bp in size, polypeptide 326 amino acids that contains the pentapeptide (GHSMG) catalytic triad residues (Ser114, Asp250 His284). Searching GenBank database shows LipA...
Sorangium cellulosum, a cellulolytic myxobacterium, is capable of producing variety bioactive secondary metabolites. Epothilones are anti-eukaryotic metabolites produced by some S. cellulosum strains. In this study, we analyzed interactions between 12 strains consisting epothilone-producers and non-epothilone producers isolated from two distinct soil habitats. Co-cultivation on filter papers showed that different inhibited one another's growth, whereas epothilone production the changed...
Extracellular alginate lyase secreted by marine Vibrio sp. YWA, isolated from decayed Laminaria japonica, was purified a combination of ammonium sulfate precipitation and diethylaminoethyl-Sephacel column chromatography. The results show that the molecular mass approximately 62.5 kDa, with an optimal pH temperature at 7.0 25 degrees C, respectively. K(m) 72.73 g/L. activity enzyme enhanced EDTA Zn(2+), but inhibited Ba(2+). substrates specificity analysis shows it specific for hydrolyzing...
Increased endogenous αB-crystallin protein levels have been shown to reduce cell apoptosis, although the effects of exogenous remain poorly understood. The present study established an acute ocular hypertension model in right eye Sprague-Dawley rats. Fluorogold retrograde tracing and immunofluorescence methods showed that number retinal ganglion cells decreased eyes caspase-3 expression increased following hypertension. Intravitreal injection reduced expression. Results demonstrated...
Abstract: Congenital upper limb anomalies (CULA) are a common birth defect and significant portion of complicated syndromic have involvement. Mostly the mortality babies with CULA can be attributed to associated anomalies. The cause majority was unknown until recently. Advances in genetic genomic technologies unraveled basis many syndromes-associated CULA, while at same time highlighting extreme heterogeneity genetics. Discoveries regarding biological pathways provide insights into...
A mitochondrial gene cluster encoding cytochrome c oxidase subunit III (COX3), an ORF (called ORF250) similar to NADH dehydrogenase VI (ND6), ten tRNA molecules, partial rRNA small and large from Trichoderma pseudokoningii S38 was cloned sequenced. These genes are tandemly clustered on the genome of S38. Phylogenetic analysis showed that C subunits exhibited high degree similarity sequences Hypocrea jecorina, Verticillium lecanii, Podospora anserine, Neurospora crassa Magnaporthe grisea (99,...
Retinal ganglion cells (RGCs) irreversibility apoptosis was the leading cause of optic nerve damage.RGCs death is a major visual impairment in neuropathies,including glaucoma,age related macular degeneration,diabetic retinopathy,uveoretinitis and vitreoretinopathy.Discharge patterns RGCs are primarily determined by presence ion channels.As most diverse group channels,potassium (K+) channels play key roles.Here to make review expression potassium its function. Key words: retinal ceils; ...