A5112483045- Vestibular and auditory disorders
- Visual perception and processing mechanisms
- Tactile and Sensory Interactions
- Ophthalmology and Eye Disorders
- Balance, Gait, and Falls Prevention
- Hearing, Cochlea, Tinnitus, Genetics
- Spaceflight effects on biology
- Ocular Surface and Contact Lens
- Multisensory perception and integration
- Motor Control and Adaptation
- Glaucoma and retinal disorders
- Neural and Behavioral Psychology Studies
- Hearing Loss and Rehabilitation
- Spatial Cognition and Navigation
- Ophthalmology and Visual Impairment Studies
- Virtual Reality Applications and Impacts
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Inertial Sensor and Navigation
- Noise Effects and Management
- Neuroscience and Neural Engineering
- Space Exploration and Technology
- Target Tracking and Data Fusion in Sensor Networks
- stochastic dynamics and bifurcation
- Migraine and Headache Studies
The Ohio State University
2017-2025
The Ohio State University Wexner Medical Center
2021-2024
Harvard University
2011-2024
Massachusetts Eye and Ear Infirmary
2011-2024
Wright-Patterson Air Force Base
2022-2024
Massachusetts Institute of Technology
1992-2020
Harvard–MIT Division of Health Sciences and Technology
2017-2020
Naval Aerospace Medical Research Laboratory
2019
Cleveland State University
2019
Laryngograph (United Kingdom)
2012-2013
A “sensory conflict” model of spatial orientation was developed. This mathematical based on concepts derived from observer theory, optimal and the properties coordinate rotations. The primary hypothesis is that central nervous system squirrel monkey incorporates information about body dynamics sensory to develop an internal model. output this (expected afference) compared actual afference, with difference defined as conflict”. conflict is, in turn, used drive estimates angular velocity...
To investigate the neural mechanisms that humans use to process ambiguous force measured by otolith organs, we vestibuloocular reflexes (VORs) and perceptions of tilt translation. One primary goal was determine if same, or different, contribute vestibular perception action. We used motion paradigms provided identical sinusoidal inter-aural cues across a broad frequency range. accomplished this sinusoidally tilting (20 degrees, 0.005-0.7 Hz) subjects in roll about an earth-horizontal,...
We measured vestibular perceptual thresholds in 105 healthy humans (54F/51M) ranging from 18 to 80 years of age. Direction-recognition were using standard methods. The motion consisted single cycles sinusoidal acceleration at 0.2 Hz for roll tilt and 1.0 yaw rotation about an earth-vertical axis, inter-aural earth-horizontal translation (y-translation), inferior-superior (z-translation), tilt. A large subset this population (99 105) also performed a modified Romberg test standing balance....
To assess the contributions of vestibular system to whole-body motion discrimination in dark, we measured direction recognition thresholds as a function frequency for yaw rotation, superior-inferior translation ("z-translation"), interaural ("y-translation"), and roll tilt 14 normal subjects 3 patients following total bilateral ablation. The had significantly higher average threshold measurements than (p < 0.01) rotation (depending upon frequency, 5.4× 15.7× greater), z-translation (8.3×...
All linear accelerometers measure gravitoinertial force, which is the sum of gravitational force (tilt) and inertial due to acceleration (translation). Neural strategies must exist elicit tilt translation responses from this ambiguous cue. To investigate these neural processes, we developed a model human simulated number motion paradigms used tilt/translation ambiguity. In model, separation GIF into estimates gravity accomplished via an internal made up three principal components: 1)...
To compare and contrast the neural mechanisms that contribute to vestibular perception action, we measured vestibuloocular reflexes (VOR) perceptions of tilt translation. We took advantage well-known ambiguity otolith organs respond both linear acceleration with respect gravity investigated by which this is resolved. A new motion paradigm combined roll inter-aural translation ("Tilt&Translation") was used; subjects were sinusoidally (0.8 Hz) tilted but their ears above or below rotation...
We previously published vestibular perceptual thresholds and performance in the Modified Romberg Test of Standing Balance 105 healthy humans ranging from ages 18 to 80 ( 1 ). Self-motion dark included roll tilt about an earth-horizontal axis at 0.2 Hz, yaw rotation earth-vertical y-translation (interaural/lateral) z-translation (vertical) Hz. In this study, we focus on multiple variable analyses not reported earlier study. Specifically, investigate correlations (1) among five measured (2)...
When making perceptual decisions, humans have been shown to optimally integrate independent noisy multisensory information, matching maximum-likelihood (ML) limits. Such ML estimators provide a theoretic limit precision (i.e., minimal thresholds). However, how the brain combines two interacting not independent) sensory cues remains an open question. To study achieved when combining signals, we measured roll tilt and rotation thresholds between 0 5 Hz in six normal human subjects. Primary...
Vestibular migraine (VM) is the most common cause of spontaneous vertigo but remains poorly understood. We investigated hypothesis that central vestibular pathways are sensitized in VM by measuring self-motion perceptual thresholds patients and control subjects characterizing vestibulo-ocular reflex (VOR) headache symptom severity. were abnormally sensitive to roll tilt, which co-modulates semicircular canal otolith organ activity, not motions activate canals or organs isolation, implying...
Controlling posture requires continuous sensory feedback about body motion and orientation, including from the vestibular organs. Little is known role of tilt vs. translation rotation cues. We examined whether intersubject differences in function were correlated with postural control. Vestibular was assayed using direction-recognition perceptual thresholds, which determine smallest that can be reliably perceived by a subject seated on motorized platform dark. In study A, we measured...
We have reported preliminary results regarding a prototype semicircular canal prosthesis and concluded that it can provide rotational cues to the nervous system. This paper presents system design of prosthesis, also reports performance effectiveness. The delivers electrical pulses nerve branch innervating horizontal on one side via implanted electrodes. To allow us encode both directions angular velocity, baseline stimulation pulse frequency was set at 150 Hz, which is somewhat higher than...
All linear accelerometers, including the otolith organs, respond equivalently to gravity and acceleration. To investigate how nervous system resolves this ambiguity, we measured perceived roll tilt reflexive eye movements in humans dark using two different centrifugation motion paradigms (fixed radius variable radius) combined with subject orientations (facing-motion back-to-motion). In fixed trials, at which was seated held constant while rotation speed changed yield changes centrifugal...
We are developing prosthetics for patients suffering from peripheral vestibular dysfunction. tested a sensory-replacement prosthesis that stimulates neurons innervating the system by providing chronic pulsatile stimulation to electrodes placed in monkeys' lateral semicircular canals, which were plugged bilaterally, and used head angular velocity modulate current pulse rate. As an encouraging finding, we observed vestibulo-ocular reflexes continued be evoked motion-modulated months after...
We are developing two types of vestibular prosthetics that electrically stimulate afferent neurons. One type replaces absent sensory function by providing stimulation modulates above and below a baseline established with the head stationary. The other provides constant is turned on only when necessary, for example, to override unnatural variations like those experienced patients suffering from MÉniÈre's syndrome; this prosthesis does not provide motion information. Both prostheses require...
Vestibular symptoms caused by migraine, referred to as vestibular are a frequently diagnosed but poorly understood entity. Based on recent evidence that normal subjects generate vestibular-mediated percepts of head motion and reflexive eye movements using different mechanisms, we hypothesized may be abnormal in migraine. We therefore measured detection thresholds patients with migraine no history symptoms, the following paradigms: roll rotation while supine (dynamically activating...