A5100318932- earthquake and tectonic studies
- Geological and Geochemical Analysis
- Geochemistry and Geologic Mapping
- Geology and Paleoclimatology Research
- High-pressure geophysics and materials
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Landslides and related hazards
- Geological formations and processes
- Paleontology and Stratigraphy of Fossils
- Geological Studies and Exploration
- Geochemistry and Elemental Analysis
- Environmental Toxicology and Ecotoxicology
- Remote Sensing and Land Use
- Land Use and Ecosystem Services
- Geological and Geophysical Studies
- Mineralogy and Gemology Studies
- Cardiomyopathy and Myosin Studies
- Receptor Mechanisms and Signaling
- Pharmacological Effects and Assays
- Geological Modeling and Analysis
- Nicotinic Acetylcholine Receptors Study
- Lipid metabolism and biosynthesis
- Remote-Sensing Image Classification
- RNA Research and Splicing
Guangxi Maternal and Child Health Hospital
2025
National Institute of Hospital Administration
2021-2024
Sun Yat-sen University
2023
Peking University
2012-2022
Peking University First Hospital
2022
King University
2022
China Earthquake Administration
2016-2021
Yunnan University
2020-2021
Institute of Disaster Prevention
2020-2021
Chinese Academy of Geological Sciences
2015-2020
In clinical practice, the emergence of ST11-K64 carbapenem-resistant Klebsiella pneumoniae (ST11-K64 CRKP) has become increasingly alarming. Despite this trend, limited research been conducted to elucidate and molecular characteristics these strains. This study aimed comprehensively investigate characteristics, antimicrobial resistance patterns, virulence-associated genes, epidemiology CRKP in Southwest China. A retrospective analysis was performed on patients infected with (CRKP) a tertiary...
Rationale: During the transition from compensated hypertrophy to heart failure, signaling between L-type Ca 2+ channels in cell membrane/T-tubules and ryanodine receptors sarcoplasmic reticulum becomes defective, partially because of decreased expression a T-tubule–sarcoplasmic anchoring protein, junctophilin-2. MicroRNA (miR)-24, junctophilin-2 suppressing miR, is upregulated hypertrophied failing cardiomyocytes. Objective: To test whether miR-24 suppression can protect structural...
Rationale: In cardiac dyads, junctional Ca 2+ directly controls the gating of ryanodine receptors (RyRs), and is itself dominated by RyR-mediated release from sarcoplasmic reticulum. Existing probes do not report such local signals because probe diffusion, so a junction-targeted sensor should reveal new information on excitation–contraction coupling its modification in disease states. Objective: To investigate signaling nanoscopic space dyads targeting sensitive biosensor (GCaMP6f) to space....
This study was initiated to evaluate mammalian target of rapamycin (mTOR) activation in renal tissue LN patients.This retrospective included 187 patients, 20 diabetic nephropathy (DN) 10 minimal change disease (MCD) patients and normal controls (NCs). Seven had repeated biopsies. mTORC1/2 evaluated by immunohistochemistry multiplexed immunofluorescence. The association with the clinicopathologic indices prognostic outcomes analysed among patients. Proteomics performed biopsies employed...
The contraction of a heart cell is controlled by Ca2+-induced Ca2+ release between L-type channels (LCCs) in the membrane/T-tubules (TTs) and ryanodine receptors (RyRs) junctional sarcoplasmic reticulum (SR). During failure, LCC–RyR signalling becomes defective. purpose present study was to reveal ultrastructural mechanism underlying defective contractility. In rat models failure produced transverse aortic constriction surgery, stereological analysis transmission electron microscopic images...
We investigate the growth of northern Tibetan Plateau and associated climate change by applying oxygen carbon isotopic compositions in Cenozoic strata southwestern Qaidam basin. The X-ray diffraction studies reveal that carbonate minerals are mainly authigenic they do not preserve any evidence for detrital diagenesis. isotope data show large fluctuations δ18O δ13C values middle–late Eocene, indicating relatively warm seasonal dry climate. positive correlation Oligocene shift from Eocene to...
Based on a digital elevation model (DEM) and GIS technology, we extracted analyzed stream geomorphic indices—such as the slope, relief degree of land surface (RDLS), hypsometric integral (HI) channel steepness index (ksn)—of Cangshan Piedmont Fault, Fengyi–Dingxiling Fault Midu Basin Margin in northern segment Red River Zone. This work indicates that all indices show higher values, with highest values along followed by lowest forming decreasing trend from north to south. lithology, climate...
βARs (β-adrenergic receptors) are prototypical GPCRs (G protein-coupled that play a pivotal role in sympathetic regulation. In heart cells, β1AR signaling mediates global response, including both l-type Ca2+ channels the sarcolemma/T tubules and RyRs (ryanodine SR (sarcoplasmic reticulum). contrast, β2AR local with little effect on function of proteins.To investigate relationship between β1ARs β2ARs.Using whole-cell patch-clamp analyses combined confocal imaging, we found activation...
Abstract The Bayin River, the largest river in northeastern Qaidam basin, plays an important role source‐to‐sink system and landscape evolution at basin‐mountain boundary between Qilian Mountains basin northern Tibetan Plateau. In this study, we conduct field observation, topographic analysis, zircon U–Pb dating, apatite (U–Th)/He dating to constrain tectonic of River watershed. Bedrock indicates age group 420–450 Ma for far‐source sediments >1,700 near‐source Detrital results from...
Abstract This study focuses on the Cenozoic provenance and tectonic evolution of southwestern Qaidam Basin through geochemical analysis detrital garnet, tourmaline rutile. The variation mineral compositions indicates that can be divided into three stages: (i) before deposition upper Xiaganchaigou Formation (before 37.8 Ma); (ii) between Shangganchaigou (from to 22 (iii) since Xiayoushashan (since Ma). In first stage, abundant garnets from high‐grade meta‐basic ultramafic rocks in sediments...
The migration of multiples can provide complementary information about the subsurface, but crosstalk artifacts caused by interference between different-order reduce its reliability. To mitigate artifacts, least-squares reverse time (LSRTM) is suggested some researchers. Multiples are more affected attenuation than primaries because longer travel path. avoid incorrect waveform matching during inversion, we propose to include viscosity in LSRTM implementation. A method introduced based on a...