A5078046676- Global Maternal and Child Health
- Child Nutrition and Water Access
- Malaria Research and Control
- Pneumonia and Respiratory Infections
- Mosquito-borne diseases and control
- Neonatal Respiratory Health Research
- Tuberculosis Research and Epidemiology
- Healthcare Systems and Reforms
- Child and Adolescent Health
- Infant Nutrition and Health
- Global Health Care Issues
- Poverty, Education, and Child Welfare
- Ocular Diseases and Behçet’s Syndrome
- Ocular Infections and Treatments
- Adolescent Sexual and Reproductive Health
- Child Nutrition and Feeding Issues
- Health disparities and outcomes
- Retinal and Optic Conditions
- Infant Development and Preterm Care
- Food Security and Health in Diverse Populations
- Respiratory viral infections research
- Breastfeeding Practices and Influences
- Maternal Mental Health During Pregnancy and Postpartum
- Eating Disorders and Behaviors
- Pharmaceutical studies and practices
Centre de Recherche en Santé de Nouna
2013-2025
Université Joseph Ki-Zerbo
2022-2023
Agence de Médecine Préventive
2021
Repeated mass distribution of azithromycin has been shown to reduce childhood mortality by 14% in sub-Saharan Africa. However, the estimated effect varied location, suggesting that intervention may not be effective different geographical areas, time periods, or conditions.
BackgroundMass distribution of azithromycin to children 1 59 months age has been shown reduce childhood all-cause mortality in some sub-Saharan African regions, with the largest reduction seen among infants younger than 12 age. Whether administration at routine health care visits for would be effective preventing death is unclear.MethodsWe conducted a randomized, placebo-controlled trial single dose (20 mg per kilogram body weight) as compared placebo, administered during infancy (5 weeks...
Background. Methylene blue (MB) has been shown to be safe and effective against falciparum malaria in Africa have pronounced gametocytocidal properties. Methods. Three days of treatment with artesunate (AS)-amodiaquine (AQ) combined MB was compared AS-AQ a randomized controlled phase IIb study; the study included 221 children aged 6–59 months uncomplicated Burkina Faso. The primary end point gametocyte prevalence during follow-up, as determined by microscopy real-time quantitative nucleic...
Body dissatisfaction and eating disorders (ED) among young females may increase in limited-resource settings as exposure to media higher-resource cultures increases. We examined ED prevalence its predictors adolescent girls rural north-western Burkina Faso.
Multimorbidity is a health issue of increasing importance worldwide, and likely to become particularly problematic in low-income countries (LICs) as they undergo economic, demographic epidemiological transitions. Knowledge the burden consequences multimorbidity LICs needed inform appropriate interventions.A cross-sectional household survey collected data on morbidities frailty, disability, quality life physical performance individuals aged over 40 years age living Nouna Health Demographic...
Abstract Background Delays in care-seeking for childhood illness may lead to more severe outcomes. We evaluated whether community distance from a primary healthcare facility was associated with decreased utilization rural district of northwestern Burkina Faso. Methods conducted passive surveillance all government-run facilities Nouna District, Faso March 1 through May 31, 2020. All visits children under 5 years age were recorded on standardized form sick children. the age, sex, and residence...
BACKGROUND: Biannual mass azithromycin administration reduces all-cause childhood mortality in some sub-Saharan African settings, with the largest effects children 1 to 5 months of age. Azithromycin has not been distributed younger than month age because risk infantile hypertrophic pyloric stenosis (IHPS). METHODS: In this 1:1 placebo-controlled trial, neonates 8 27 days were randomly assigned a single oral dose (20 mg/kg) or an equivalent volume placebo five regions Burkina Faso during 2019...
Abstract Background Maternal age is increasingly recognized as a predictor of birth outcomes. Given the importance and growth outcomes for children’s development, wellbeing survival, this study examined effect maternal on infant at 6 months mortality. Additionally, we conducted quantitative bias analysis (QBA) to estimate role selection unmeasured confounding Methods We used data from randomized–controlled trials (RCTs) 21 555 neonates in Burkina Faso 2019–2020. Newborns mothers aged 13–19...
Mass antibiotic distribution to preschool children resulted in alterations of the gut microbiome months after distribution. This individually randomized, placebo-controlled trial evaluated changes and resistome aged 8 days 59 one dose oral azithromycin Burkina Faso. A total 450 were randomized a 1:1 ratio either placebo or azithromycin. Rectal samples collected at baseline, 2 weeks, 6 randomization subjected DNA deep sequencing. Gut diversity normalized antimicrobial resistance determinants...
BackgroundSexual victimisation and peer are pervasive increase risk for mental illness. Longitudinal studies that compare their unique cumulative effects scarce have been done predominantly in high-income countries. The aims of this study were to examine the prevalence, prospective associations, gender differences sexual health a low-income, African setting.MethodsIn cohort study, data obtained from 2017 ARISE Adolescent Health Study, population-representative, two-wave, adolescents (aged...
Background Antibiotic use during early infancy has been linked to childhood obesity in high-income countries. We evaluated whether a single oral dose of azithromycin administered infant-well visits led changes infant growth outcomes at 6 months age setting with high prevalence undernutrition rural Burkina Faso. Methods and findings Infants were enrolled from September 25, 2019, until October 22, 2022, randomized controlled trial designed evaluate the efficacy (20 mg/kg) compared placebo when...
To assess the efficacy of methylene blue (MB) monotherapy in semi-immune adults with uncomplicated malaria Burkina Faso.In an open-label controlled phase II study 60 falciparum Nouna, north-western Faso, MB (390 mg twice daily) was given sequentially to groups 20 for 7 days (MB7), 5 (MB5) and 3 (MB3), respectively. The primary outcome rate adequate clinical parasitological response (ACPR) on day 28 follow-up.Of population, 27/58 (47%) 5/51 (10%) patients still had parasites 2 3,...
Little is known about the prevalence of frailty and normal values for physical performance among older individuals in low-income countries, particular those sub-Saharan Africa. We describe phenotypic frailty, correlates several measures a cohort middle-aged people living rural Burkina Faso, one world's poorest communities.
Malariometric information is needed to decide how introduce malaria vaccines and evaluate their impact in sub-Saharan African countries. This cross-sectional study (NCT01954264) was conducted between October November, 2013, corresponding the high transmission season, four sites with Health Demographic Surveillance Systems (DSS) [two moderate-to-high endemicity Burkina Faso (Nouna Saponé) two low Senegal (Keur Socé Niakhar)]. Children (N = 2421) were randomly selected from DSS lists of...
To contribute to the current understanding of depressive disorders in sub-Saharan African (SSA) countries by examining association symptoms with cardiovascular and cardiometabolic conditions a population-based study middle-aged older adults rural Burkina Faso.This was conducted Nouna Health Demographic Surveillance System north-western Faso, mixed small-town environment. The data were obtained between May July 2018.Consenting over 40 years age (n=3026).Depressive assessed using Patient...
ABSTRACT. This study examines the association between antenatal care (ANC) attendance and infant mortality growth outcomes. The used data from Nouveux-nés et Azithromycine: une Innovation dans le Traitement des Enfants (NAITRE) trial conducted in Burkina Faso. analysis included 21,795 neonates aged 8 to 27 days who were enrolled had ANC available. Infants followed until 6 months of age. adjusted for potential confounders including infant’s sex, maternal age, education, urbanicity, geographic...
Abstract Objective: Most evidence supporting screening for undernutrition is children aged 6–59 months. However, the highest risk of mortality and incidence wasting occurs in first 6 months life. We evaluated relationships between neonatal anthropometric indicators, including birth weight, weight-for-age Z -score (WAZ), weight-for-length Z-score (WLZ), length-for-age (LAZ) mid-upper arm circumference (MUAC) growth at age among infants Burkina Faso. Design: Data arose from a randomised...
Childhood malnutrition remains a major challenge to public health in poor countries. Data on determinants African children are scarce. A cross-sectional survey was performed eight villages of Burkina Faso June 2009, including 460 aged 6–31 months. Demographic, socioeconomic, parasitological, clinical and anthropometric characteristics were collected. The main outcome variable weight-for-length (WFL) z-score (i.e. wasting). multiple regression model identified village, age group, religion the...
The relationship between malaria infection and malnutrition is complex. Using data from a randomized controlled trial of 450 children 0-5 years age in Burkina Faso, we examined the effect on short-term changes anthropometric measures, infection, whether modified baseline measures infection. Malaria assessed by blood smear microscopy weight, height, mid-upper arm circumference, height-for-age z-score, weight-for-age weight-for-height z-score were measured at three time points: baseline, 2...
Abstract Background Biannual, mass azithromycin distribution has previously been shown to reduce all-cause child mortality in sub-Saharan Africa. Subgroup analysis suggested that the strongest effects were youngest children, leading hypothesis targeting younger age groups might be an effective strategy prevent mortality. We present methods of two randomized controlled trials designed evaluate and targeted for prevention Burkina Faso, West Methods/design The Child Health with Azithromycin...
Abstract Objective For measurement of progress towards the Millennium Development Goal (MDG) 1, reliable data on nutrition indicators specific countries are essential. Malnutrition is also main determinant for childhood mortality, which addressed in MDG 4. Methods In health and demographic surveillance area Kossi Province north‐western Burkina Faso, nutritional parameters were compared two cohorts young children same age range from eight villages. Surveys took place June December year 1999...
Observational studies have linked early-life antibiotic exposure to increased risk of obesity in children high income settings. We evaluated whether neonatal led changes infant growth at 6 months age Burkina Faso. Neonates aged 8 27 days who weighed least 2,500 g the time enrollment were randomized a 1:1 fashion single oral 20-mg/kg dose azithromycin or equivalent volume placebo from April 2019 through December 2020. Weight, length, and mid-upper-arm circumference (MUAC) measured baseline...
Biannual mass azithromycin distribution to children aged 1-59 months has been shown reduce all-cause mortality. Children under 28 days of age were not treated in studies evaluating for child mortality due concerns related infantile hypertrophic pyloric stenosis (IHPS). Here, we report the design a randomised controlled trial evaluate efficacy and safety administration single dose oral during neonatal period. The Nouveaux-nés et Azithromycine: une Innovation dans le Traitement des Enfants...
Of 61 355 visits by children <5 years old to 48 government-run primary healthcare facilities in Nouna District, Burkina Faso, 30 975 had an antibiotic prescribed (58% for pneumonia diagnoses). A minority of prescriptions were diagnoses not requiring antibiotics, including malaria, nonbloody diarrhea, and cough without pneumonia.