A5020931494- Malaria Research and Control
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Pregnancy and preeclampsia studies
- Complement system in diseases
- Neonatal Health and Biochemistry
- Hemoglobinopathies and Related Disorders
- Methemoglobinemia and Tumor Lysis Syndrome
- Child Nutrition and Water Access
- Parasites and Host Interactions
- Travel-related health issues
- COVID-19 Impact on Reproduction
- SARS-CoV-2 and COVID-19 Research
- Neuroendocrine regulation and behavior
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- Computational Drug Discovery Methods
- Trypanosoma species research and implications
- Pregnancy and Medication Impact
- Drug-Induced Hepatotoxicity and Protection
- Poverty, Education, and Child Welfare
- Reproductive System and Pregnancy
- Viral Infections and Outbreaks Research
- Vaccine Coverage and Hesitancy
University of California, San Francisco
2016-2025
Global Brain Health Institute
2023-2025
U.S. President's Malaria Initiative
2024-2025
Washington University in St. Louis
2020-2022
Potrero Medical (United States)
2021
University of South Florida
2020
Yale University
2016-2017
Mbarara University of Science and Technology
2016
Epicentre Uganda
2016
Médecins Sans Frontières
2016
SummaryBackgroundIn Africa, the scale-up of malaria-control interventions has reduced malaria burden, but progress towards elimination stalled. Mass drug administration (MDA) is promising as a transmission-reducing strategy, evidence from low-to-moderate transmission settings needed. We aimed to assess safety, coverage, and effect three cycles MDA with dihydroartemisinin–piperaquine plus single, low-dose primaquine on Plasmodium falciparum incidence prevalence in southeast Senegal.MethodsWe...
BackgroundPrimaquine and methylene blue are gametocytocidal compounds that could prevent Plasmodium falciparum transmission to mosquitoes. We aimed assess the efficacy safety of primaquine in preventing human mosquito P among glucose-6-phosphate dehydrogenase (G6PD)-normal, gametocytaemic male participants.MethodsThis was a phase 2, single-blind, randomised controlled trial done at Clinical Research Centre Malaria Training (MRTC) University Bamako (Bamako, Mali). enrolled participants aged...
Significance The myeloproliferative neoplasms (MPNs) are a group of hematological malignancies characterized by increased numbers myeloid blood cells, such as platelets, erythrocytes, and neutrophils. main causes illness death in patients with MPNs arterial venous clotting also, conversely, bleeding complications. However, the these conditions poorly understood. In this paper, we use mouse model to determine cell types responsible for abnormal MPNs. We demonstrate that endothelial type lines...
Abstract Background To better understand transmission dynamics, we characterized Plasmodium falciparum genetic diversity in Eswatini, where is low and sustained by importation. Methods Twenty-six P. microsatellites were genotyped 66% of confirmed cases (2014–2016; N = 582). Population within-host used to characterize differences between imported locally acquired infections. Logistic regression was assess the added value metrics classify local infections beyond epidemiology data alone....
Trials of intermittent preventive treatment (IPTp) malaria in pregnant women that compared dihydroartemisinin-piperaquine with the standard care, sulfadoxine-pyrimethamine, showed was superior at preventing infection, but not improving birthweight. We aimed to assess whether sulfadoxine-pyrimethamine shows greater non-malarial benefits for birth outcomes than does dihydroartemisinin-piperaquine, and antimalarial sulfadoxine-pyrimethamine.We defined as random assignment or before pooling...
In March 2020, the government of Uganda implemented a strict lockdown policy in response to COVID-19 pandemic. Interrupted time series analysis (ITSA) was performed assess whether major changes outpatient attendance, malaria burden, and case management occurred after onset epidemic rural Uganda.Individual level data from all visits collected April 2017 2021 at 17 facilities were analysed. Outcomes included total visits, cases, non-malarial proportion patients with suspected malaria, tested...
Abstract Background Trials evaluating antimalarials for intermittent preventive treatment in pregnancy (IPTp) have shown that dihydroartemisinin-piperaquine (DP) is a more efficacious antimalarial than sulfadoxine-pyrimethamine (SP); however, SP associated with higher birthweight, suggesting demonstrates “nonmalarial” effects. Chemoprevention of nonmalarial febrile illnesses (NMFIs) was explored as possible mechanism. Methods In this secondary analysis, we leveraged data from 654 pregnant...
Importance Two interventions to prevent severe respiratory syncytial virus (RSV) in infants were approved 2023—a bivalent prenatal RSV prefusion F protein–based (RSVpreF) vaccine and an infant monoclonal antibody (nirsevimab). Understanding their uptake clinical outcomes is essential for public health planning. Objective To describe of the RSVpreF nirsevimab. Design, Setting, Participants This retrospective cohort study was conducted at a single academic center among 647 pregnant individuals...
Background We conducted a double-blinded, randomized, controlled trial of 2757 pregnant women in Uganda, where resistance malaria parasites to sulfadoxine-pyrimethamine is widespread. Women were randomly assigned (1:1:1) monthly IPTp with sulfadoxine-pyrimethamine, dihydroartemisinin-piperaquine, or dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine. The primary outcome was the risk composite adverse birth defined as any following: spontaneous abortion, stillbirth, low birthweight...
Effective and safe COVID-19 vaccines have been developed resulted in decreased incidence severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can decrease secondary transmission. However, there are concerns about dampened immune responses to vaccination among immunocompromised patients, including people living with HIV (PLWH), which may blunt the vaccine's efficacy durability protection. This study aimed assess qualitative SARS-CoV-2 vaccine immunogenicity PLWH...
Indoor residual spraying of insecticide (IRS) is a key intervention for reducing the burden malaria in Africa. However, data on impact IRS pregnancy and birth outcomes limited. An observational study was conducted within trial intermittent preventive therapy during Tororo, Uganda. Women were enrolled at 12–20 weeks gestation between June October 2014, provided with insecticide-treated bed nets, followed through delivery. From December 2014 to February 2015, carbamate-containing implemented...
A survey of asymptomatic children in Uganda showed Plasmodium malariae and P. falciparum parasites 45% 55% microscopy-positive samples, respectively. Although 36% samples were negative by rapid diagnostic test, 75% or ovale PCR, indicating that routine testing misses many non-P. malarial infections.
Abstract Gametocyte density and sex ratio can predict the proportion of mosquitoes that will become infected after feeding on blood patients receiving nongametocytocidal drugs. Because primaquine methylene blue sterilize gametocytes before affecting their ratio, mosquito experiments are required to demonstrate early transmission-blocking effects.
Oxytocin is a potent uterotonic agent administered to nearly all patients during childbirth in the United States. Inadequate oxytocin response can necessitate Cesarean delivery or lead uterine atony and postpartum hemorrhage. Thus, it may be clinically useful identify at risk for poor develop strategies sensitize uterus oxytocin. Previously, we showed that V281M variant receptor (OXTR) gene impairs OXTR trafficking cell surface, leading decreased cells. Here, sought pharmacological...
Despite scale-up of seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine (SP-AQ) in children 3-59 months age Burkina Faso, incidence remains high, raising concerns regarding SMC effectiveness selection drug resistance. Using a case-control design, we determined associations between levels, resistance markers, presentation malaria.