Abstract Research ethics education is critical to developing a culture of responsible conduct research. Many countries in sub-Saharan Africa (SSA) have high burden infectious diseases like HIV and malaria; some, Uganda, recurring outbreaks. Coupled with the increase non-communicable diseases, researchers access large populations test new medications vaccines. The need develop multi-level capacity research Uganda still huge, being compounded by disease challenging public health issues. Only...

Abstract Introduction Treatment abandonment contributes significantly to poor survival of children with cancer in low‐ and middle‐income countries (LMIC). In order inform an approach this problem, we investigated why caregivers withdraw their from treatment. Methods a qualitative study, carried out October November 2020, in‐depth interviews were conducted who had abandoned treatment at the Pediatric Cancer Unit Mbarara Regional Referral Hospital south‐western Uganda. Recorded transcribed...

A survey of asymptomatic children in Uganda showed Plasmodium malariae and P. falciparum parasites 45% 55% microscopy-positive samples, respectively. Although 36% samples were negative by rapid diagnostic test, 75% or ovale PCR, indicating that routine testing misses many non-P. malarial infections.

Events such as the Tuskegee syphilis study shaped how public perceives and trusts medical research globally. However, few studies have examined trust in developing countries. We tested hypothesis that levels of may be lower among community members compared to hospitalized persons Uganda. enrolled 296 participants rural northern Uganda, 148(50%) were from community, 192(65%) female. Mean level for was higher (p = 0.0001). Previous participation 0.03), willingness participate future 0.001)...

Diabetic nephropathy (DN) is a common finding in diabetic patients. Microalbuminuria the earliest clinical evidence of DN. Early detection microalbuminuria very important; it allows timely interventions to prevent progression macroalbuminuria and later end-stage renal disease (ESRD).To determine prevalence patients establish its association with traditional serum markers assessment incipient nephropathy.This cross-sectional study involved 140 participants diabetes mellitus (DM) attending...

Despite the potential benefit of primaquine in reducing Plasmodium falciparum transmission and radical cure vivax ovale infections, concerns over risk hemolytic toxicity individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDd) have hampered its deployment. A cross-sectional survey was conducted 2014 to assess G6PDd prevalence among 631 children between 6 59 months age southwestern Uganda, an area where may be a promising control measure. determined using three detection methods:...

Population based cancer registries (PBCRs) are accepted as the gold standard for estimating incidence in any population. However, only 15% of world's population is covered by high quality with coverage low 1.9% settings such Africa. This study was conducted to assess operational feasibility using a retrospective "catchment population" approach Uganda.A 2018 identify all newly diagnosed cases between 2013 and 2017 Mbarara district. Data were extracted from medical records health facilities...

The use of bacteria to clean up oil-contaminated soils is widely considered the most desirable bioremediation strategy. majority research has focused on contaminated in large oil-producing countries. However, accidental spills or poor handling and disposal petroleum hydrocarbons (PHs) products, which happen at automobile maintenance garages leakages fuel stations contaminate soil. There limited information PH-degrading soil patches around for their possible potential. We characterized with...

Purpose: We aimed at determining the distribution of ACE insertion/deletion gene polymorphisms among type 2 diabetic patients and their association with nephropathy biomarkers metabolic indicators. Patients Methods: Data were collected from 237 adult diabetes mellitus receiving healthcare clinic Mbarara Regional Referral Hospital. Peripheral blood genomic DNA was amplified using a conventional PCR technique analyzed for homozygous forms insertion (II), deletion (DD) heterozygous (ID)...

Early diagnosis of suspected malaria cases with a rapid diagnostic test (RDT) has been shown to be an effective control tool used in many resource-constrained settings. However, poor quality and assurance hinder the accurate reporting diagnoses. Recent use portable, battery operated RDT reader (Deki Reader™, Fio Corporation) have high agreement visual inspection across diverse health centre settings, however evidence its feasibility usability during cross sectional surveys are limited. This...

Background: Given the importance of CD4-T-lymphocyte monitoring in HIV/ART management, we established CD4/CD8 reference ranges Uganda and studied factors associated with a normal population. Methods: Blood samples for 206 HIV seronegative healthy volunteers from Mbarara Kampala districts were analyzed using PanLeucogating protocol. Results: The reported include data 172 participants no current or serious recent health problems. 95% absolute CD4 (ACD4) count was 418-2105 cells/µL, 2561619 CD8...

We describe the diversity of Plasmodium falciparum populations in western Uganda and assess role that asymptomatic malaria carriers with sickle cell trait (HbAS) may be playing on population structure. genotyped P. 291 samples using merozoite surface protein (MSP) 1 2 loci. Extensive genetic was detected among symptomatic children Mbarara (20 MSP1 alleles; 31 MSP2 alleles) Kagando, Kasese (19 30 alleles). Multiplicity infection (MOI) significantly higher than Mbarara, 2.7 2.1 genotypes/PCR...

An assessment of iron status was made on 96 pregnant women and 29 non-pregnant, non-lactating menstruating comparable age group as controls. Anaemia (haemoglobin < 110 g/l) present in 84.4% the 48.3% control group. Iron deficiency (serum ferritin 12.0 micrograms/l) 51.1% 37.9% Prevalence anaemia with 54.7% anaemic women. Serum correlated significantly low haemoglobin (P 0.05). Median serum declined progressively until 31 weeks gestation. Preliminary studies their dietetics showed that animal...

Background. Laboratory animals are commonly fed on cereal-based diets (CBDs) whose nutrient composition is unknown and may confound the metabolic response to study interventions. Purified such as AIN-93M therefore recommended, their known. However, few studies have evaluated use adequate control diets. The aim of this was compare nutrition status Swiss albino mice either CBD or for 15 weeks. Methods. Twenty aged 6–8 weeks weighing 21.7 g ± 0.6 were diet Their nutritional using anthropometric...

Background Kidney dysfunction is a common finding among patients with diabetes mellitus. We sought to determine the prevalence and contributors kidney type 2 mellitus (T2D) patients. Methods In this descriptive analytical cross-sectional study, we received consent enrolled 148 T2D attending diabetic clinic of Soroti Regional Referral Hospital in eastern Uganda from May 2023 July 2023. used questionnaires obtain participants' socio-demographic behavioral characteristics. Blood urine samples...

Abstract Background In this cross-sectional study, we aimed at determining the association between biomarkers of nephropathy and ACE insertion/deletion gene polymorphisms among type 2 diabetic patients. Methods Data were collected from 237 adult diabetes mellitus patients receiving healthcare clinic Mbarara Regional Referral Hospital. Peripheral blood genomic DNA was amplified using a conventional PCR technique analyzed for homozygous forms insertion (II), deletion (DD) heterozygous (ID)...

Introduction Zinc deficiency (ZnD) impairs the development of acquired immunity and contributes to growth failure in children under five years age. However, prevalence ZnD its association with this age group Uganda have not been well explored. This study aimed determine explore associations between low serum zinc levels total white blood cell count, differential counts, IL-1 IL-2 aged 12 59 months. Methods In cross-sectional study, we enrolled months upon admission pediatrics ward Masaka...

A cross-sectional study was conducted in five districts South Western Agro-Ecological Zone (SWAEZ), Uganda, to map pig breed distribution and determine their abundance population structure. Purposive snowball sampling methods were used identify farmers whose pigs included the study. Pig breeds identified using NAADS user guide on husbandry. The that properly Camborough, Landrace, Large White; crosses locally adapted populations not differentiated into specific breeds. Camborough least...

The study to document phenotypic characteristics of locally adapted pigs was carried out in South-Western Agro-ecological Zone (SWAEZ) Uganda. 784 households were included; keeping a total 3032 including piglets. Only one adult pig each household used for recording characteristics. These included 252 males and 1032 females totalling 1284 pigs. Piglets (0-3 months old) constituted slightly bigger percentage the population 1149 (38%), followed by 1084 (34%), growing 361 (11.9%), (8.3%) (7.8%),...

Introduction - Treatment abandonment contributes significantly to poor survival of children with cancer in low-middle-income countries (LMICs). In order inform an approach this problem at our Cancer Unit, we investigated why caregivers withdraw their from treatment. Methods – a qualitative study, in-depth interviews were conducted who had abandoned treatment the Paediatric Unit (PCU) Mbarara Regional Referral Hospital (MRRH) South Western Uganda, between May 2017 and September 2020. Recorded...