A5021912995- Cervical Cancer and HPV Research
- Ocular Oncology and Treatments
- Cytomegalovirus and herpesvirus research
- Cancer, Lipids, and Metabolism
- Retinopathy of Prematurity Studies
- Urinary and Genital Oncology Studies
- Urologic and reproductive health conditions
- Nonmelanoma Skin Cancer Studies
- Diabetes Management and Research
- Gallbladder and Bile Duct Disorders
- Reproductive tract infections research
- Lymphoma Diagnosis and Treatment
- Prenatal Screening and Diagnostics
- Genital Health and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Parasites and Host Interactions
- Moringa oleifera research and applications
- Diabetes Management and Education
- Urological Disorders and Treatments
- Intestinal and Peritoneal Adhesions
- IgG4-Related and Inflammatory Diseases
- Drug-Induced Hepatotoxicity and Protection
- Abdominal Surgery and Complications
- Global Health and Surgery
- Lysosomal Storage Disorders Research
Mbarara University of Science and Technology
2018-2025
Mbarara National Referral Hospital
2024
Fatebenefratelli Hospital
2023
Soroti University
2023
Abstract Background In Sub-Saharan Africa, the prevalence of dyslipidemia is on rise, with studies showing as a contributing factor to progression premalignant lesions cervical cancer. Uganda, cancer and are common health concerns, considering increasing trends in general population inadequate information regarding lesions. This study aimed determine its association precancerous cancerous cervix among women attending clinic at Uganda Cancer Institute. Methods cross-sectional was conducted...
Background Antiretroviral therapy (ART) restores cellular immunity, significantly reducing AIDS-related mortality and morbidity thus improving the quality of life among People living with HIV (PLHIV). Studies done in several countries show a decline AIDS defining cancers (ADCs) introduction ART however increased longevity has led to increase Non-AIDS (NADCs). The study was aimed at studying changing spectrum trends cancer Human Immunodeficiency Virus (HIV) patients southwestern Uganda....
Reactivation of central nervous system (CNS) toxoplasmosis can be caused by immunosuppression (ISS) any kind. However, anti-cancer chemotherapy combined with human immunodeficiency virus (HIV) induced ISS results in an atypical presentation that is fatal. A 46 years old man a well-controlled infection the presented generalized tonic-clonic seizures following second dose for esophageal cancer. His brain's computerized tomography (CT) scan showed enlarged ventricles no space-occupying lesions....
The plasma-thrombin method is commonly used to make cell blocks from fine-needle aspiration (FNA) samples but requires centrifugation. We describe a modification this that does not require centrifugation for use in resource-limited settings.Pooled fresh plasma aliquoted into 2-mL Eppendorf tubes and the FNA sample directly rinsed plasma. Two drops of reconstituted thrombin are added gently mixed. A clot transferred tissue bag, fixed formalin, processed. This was applied 44 patients...
Population based cancer registries (PBCRs) are accepted as the gold standard for estimating incidence in any population. However, only 15% of world's population is covered by high quality with coverage low 1.9% settings such Africa. This study was conducted to assess operational feasibility using a retrospective "catchment population" approach Uganda.A 2018 identify all newly diagnosed cases between 2013 and 2017 Mbarara district. Data were extracted from medical records health facilities...
Introduction: Gaucher disease is a rare autosomal recessive lysosomal storage with unknown prevalence in Africa and no record of the exists Uganda. Case Presentation: We report case 12-year-old female, last born 6 from family known familial who presented non-neuronopathic superimposed malaria. The was initially misdiagnosed as hyperreactive malarial splenomegaly but subsequently confirmed by examination bone marrow smear core. managed supportively splenectomy done due to worsening...
Purpose: The determination of the presence or absence anaplasia in Wilms tumor is difficult sometimes creating diagnostic errors and worsened by use neoadjuvant chemotherapy, which causes cellular alterations that may mimic anaplasia. This study described histological features their association with WT1 p53 expression archived specimens South Western Uganda. Patients Methods: A series 308 formalin-fixed paraffin-embedded tissue blocks belonging to 85 children were retrospectively recruited...
Abstract Background Uganda has approximately 1.2 million people aged 15–64 years living with human immunodeficiency virus (HIV). Previous studies have shown a higher prevalence of premalignant cervical lesions among HIV-positive women than HIV-negative women. Additionally, HIV-infected are more likely to papilloma (HPV) infection progress cancer not infected HIV. We determined the and their association HIV attending screening clinic at Mbarara Regional Referral Hospital (MRRH) in...
Abstract Background Prostate cancer is the leading cause of cancer-related death and second most commonly diagnosed among men in Uganda countries Sub-Saharan Africa (SSA). The TMPRSS2-ERG fusion gene common genetic alteration seen prostate patients. There are several contradicting reports about association ERG protein with poor prognosis, high PSA, Gleason score. This study determined prevalence expression relationship score, Age patients Southwestern Uganda. Methods We reviewed 130 archived...
Introduction: There are high incidence and mortality rates of cervical cancer among females in East Africa. This is exacerbated by limited up-to-date data on premalignant lesions associated factors this setting. In study, we determined the prevalence intraepithelial women attending Mbarara Regional Referral Hospital clinic Southwestern Uganda. Methods: cross-sectional 364 participants were recruited from 1 April to 30 June 2023. On consent, study nurse collected demographic Pap smears, which...
Background . Hyperglycemia in pregnancy complicates up to 30% of pregnancies Africa, and this poses a major risk both the mother fetus. Although recommended by World Health Organization (WHO), universal screening for hyperglycaemia is not routinely done many hospital low- middle-income countries. This study sought determine frequency factors associated with first detected at general public South Western Uganda. Methods We conducted Itojo General Hospital (IGH) Ntungamo District, The followed...
The diagnosis of extrahepatic obstructive jaundice (EHOJ) remains a challenge and is often made late in low-resource settings. Systematic data are limited on the etiology prognosis patients with Uganda. objective this study was to determine etiology, clinical presentations, short-term treatment outcomes managed for EHOJ at Mbarara Regional Referral Hospital (MRRH) south-western Uganda.Between September 2019 May 2020, we prospectively enrolled cohort who presented MRRH. A pretested,...
Aim: Medicinal plants have played an important role in the treatment of different ailments including malaria developing countries particularly Africa. This study has evaluated antimalarial activities Azadirachta indica A. Juss (Meliaceae), Cymbopogon citratus Stapf. (Poaceae), Moringa oleifera Lam. (Moringaceae), Tithonia diversifolia (Hemsl) Grey (Asteraceae) and Vernonia amygdalina Del. which are commonly-used for Uganda.
 Study Design: is experimental laboratory report on some...
Extrapulmonary drug-resistant tuberculosis is extremely rare and almost always associated with poor treatment outcomes. This partly due to the difficulty in confirming diagnosis.A 40-year-old HIV-negative male presented a painless scrotal mass, low-grade fever, general malaise, night sweats, no pulmonary symptoms. He was initially treated for malaria improvement. His final diagnosis rifampicin-resistant following Xpert® MTB/RIF Ultra (Xpert-Ultra) assay performed on fine needle aspirate of...
Purpose: Head and Neck squamous cell carcinoma (HNSCC) is the seventh most common cancer in world. The prognosis of patients with HNSCC remains unsatisfactory, a 5-years survival rate only approximately 50%. In western Uganda, 1-year 1%. Programmed death ligand 1 (PD-L1) p16 have been shown to predict progression lesions, prognosticate survival, reveal new therapeutic targets, response agents. positive PD-L1 expression reported benefit from immunotherapy; however, data on Uganda Africa are...
<title>Abstract</title> <bold>Background: </bold>Nontraumatic ileal perforation is a cause of obscure peritonitis characterized by severe toxicity and high mortality. This burden disproportionately greater in LMICs due to poor hygiene practices, HIV infection, other comorbidities. study aimed determine the prevalence, anatomic-pathologic findings, associated factors nontraumatic at 3 selected hospitals Uganda. <bold>Methodology:</bold> was cross-sectional 149 consecutive sample participants...
Despite advances in hookworm control and prevention campaigns, the prevalence remains high sub-Saharan Africa. Iron deficiency anaemia is a major complication those with prolonged infection, burden, undernutrition, though most infected people are asymptomatic. While patients commonly diagnosed by presence of ova or cysts stool, gastrointestinal (GI) endoscopy required for negative stool tests chronic iron anaemia. A 48-year-old female symptoms nearly two years presented to Mbarara Regional...
To determine the association between MetS and its components with cervical cancer among women in South-western Uganda. We conducted an unmatched case-control study on 470 participants a 1:2 case-to-control ratio southwestern recruited 157 as cases 313 without controls at Mbarara Regional Referral Hospital Cervical Cancer Clinic. assessed for using National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) criteria. used multivariable binary logistic regression analysis...
Purpose: Formalin-fixed tissue biopsies submitted to the Histopathology Laboratory were explored for possible use in GeneXpert MTB/Rifampicin assay EPTB diagnosis, therefore this study aimed determine diagnostic utility of MTB/RIF detection formalin-fixed paraffin-embedded using Ziehl-Neelsen (ZN) and Haematoxylin Eosin (H&E) staining as a composite reference standard. Methods: A total 89 selected archived tissues with histological features tuberculosis included study. ZN H&E performed...
ABSTRACT Background: Schistosomiasis is an acute and chronic tropical disease caused by trematodes of the genus Schistosoma. It a public health concern mostly affects developing countries tropics. According to WHO burden as high 80-85%, principally in sub-Saharan Africa. Although majority infection often linked with morbidity, it also results considerable death. The overall annual mortality rate might exceed 200,000 people Africa due different complications urinary intestinal...
<title>Abstract</title> <bold>Background</bold>: Uganda has approximately 1.2 million people aged 15–64 years living with human immunodeficiency virus (HIV). Previous studies have shown a higher prevalence of premalignant cervical lesions among HIV-positive women than HIV-negative women. Additionally, HIV-infected womenare more likely to their papilloma (HPV) infection progress cancer non-HIV-infected We determined the and association HIV attending screening clinic at Mbarara Regional...