Margaret C. Hardy

ORCID: 0000-0001-5033-4322
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About
Contact & Profiles
Research Areas
  • Insect and Pesticide Research
  • Insect Resistance and Genetics
  • Monoclonal and Polyclonal Antibodies Research
  • Health and Medical Research Impacts
  • Venomous Animal Envenomation and Studies
  • Doctoral Education Challenges and Solutions
  • Antimicrobial Peptides and Activities
  • scientometrics and bibliometrics research
  • Transgenic Plants and Applications
  • Salmonella and Campylobacter epidemiology
  • Species Distribution and Climate Change
  • Rabies epidemiology and control
  • Career Development and Diversity
  • Insect Pest Control Strategies
  • Toxin Mechanisms and Immunotoxins
  • Radiopharmaceutical Chemistry and Applications
  • Fire effects on ecosystems
  • T-cell and B-cell Immunology
  • Conservation, Ecology, Wildlife Education
  • Disaster Response and Management
  • Mycobacterium research and diagnosis
  • Education Discipline and Inequality
  • Melanoma and MAPK Pathways
  • Biochemical and Structural Characterization
  • Immunotherapy and Immune Responses

Rocky Mountain Research (United States)
2024

Rocky Mountain Research Station
2024

University of the Sunshine Coast
2023

Cancer Council Australia
2020

Australian Diabetes Society
2019

National Center for Emerging and Zoonotic Infectious Diseases
2019

Centers for Disease Control and Prevention
2019

CDC Foundation
2019

Powerscreen (United Kingdom)
2018

The University of Queensland
2012-2017

Abstract Biochar production from woody biomass generated during forest management (slash) offers significant benefits for soil health and carbon emissions, yet its adoption remains limited in the western United States (U.S.). To address this challenge, U.S. Department of Agriculture (U.S.D.A.) Forest Service Rocky Mountain Research Station organized two workshops focused on management-centric biochar production. These convened a diverse group stakeholders, including investors, land...

10.1007/s42773-023-00290-2 article EN cc-by Biochar 2024-01-02

Many insect pests have developed resistance to existing chemical insecticides and consequently there is much interest in the development of new insecticidal compounds with novel modes action. Although spiders deployed toxins their venoms for over 250 million years, no evolutionary selection pressure on these possess oral activity since they are injected into prey predators via a hypodermic needle-like fang. Thus, it has been assumed that spider-venom peptides not orally active therefore...

10.1371/journal.pone.0073136 article EN cc-by PLoS ONE 2013-09-11

Over-expression of Aurora-A (Aurora 2 kinase, STK-15), a protein found in centrosomes thought to be associated with genetic instability, has been previously documented prostate cancer [Pihan et al.: Cancer Res 61(5):2212-2219, 2001]. It is unknown if this also over-expressed high-grade prostatic intraepithelial neoplasia (PIN) lesions.PIN lesions were examined for increased using immunohistochemical staining on archival paraffin embedded prostatectomy tissue. expression was scored size,...

10.1002/pros.20247 article EN The Prostate 2005-03-07

Powerline rights-of-way (ROWs) often provide habitat for early successional bird species that have suffered long-term population declines in eastern North America. To determine how the abundance of shrubland birds varies with within ROW corridors and land use patterns surrounding corridors, we ran Poisson regression models on data from 93 plots ROWs compared coefficients. We also determined nest success rates a 1-km stretch ROW. Seven were common powerline corridors. However, prairie warbler...

10.1371/journal.pone.0031520 article EN cc-by PLoS ONE 2012-02-20

Spider neurotoxins are commonly used as pharmacological tools and a popular source of novel compounds with therapeutic agrochemical potential. Since venom peptides inherently toxic, the host spider must employ strategies to avoid adverse effects prior use. It is partly for this reason that most toxins encode protective proregion upon enzymatic cleavage excised from mature peptide. In order identify toxin sequence directly transcripts, without resorting protein sequencing, propeptide site in...

10.1371/journal.pone.0066279 article EN cc-by PLoS ONE 2013-07-22

Conventional chemical control compounds used for the management of insect pests have been much maligned, but still serve a critical role in protecting people and agricultural products from pests, as well conserving biodiversity by eradicating invasive species. Although biological can be an effective option area-wide established methods are important use integrated pest (IPM) programs, export treatments, recently arrived species, minimizing population explosions vectors human disease....

10.3390/insects5010227 article EN cc-by Insects 2014-01-23

AbstractThe bulk of "neighborhood effects" research examines the impact neighborhood conditions cross-sectionally. However, it is critical to understand whether effects context are situational and they endure over time. In this study, we take seriously notion that there enduring consequences exposure deleterious conditions. Using a rich set longitudinal data on adolescents from Project Human Development in Chicago Neighborhoods, estimate effect violence both internalizing (depression...

10.1080/07418825.2012.737471 article EN Justice Quarterly 2012-11-09

Abstract Enteric glia, the support cells of myenteric ganglia, have been widely studied with respect to their morphology and immunohistochemical phenotype, but little is known about functional properties. We developed a method for amplification enteric glia from newborn guinea pigs further characterize these cells. Treatment combination basic fibroblast growth factor adenylate cyclase activator, cholera toxin, permitted expansion glial cultures confluence serial passage up 8 months. The...

10.1002/jnr.490340104 article EN Journal of Neuroscience Research 1993-01-01

Abstract When discussing the postdoctoral period in a researcher’s life, lack of career progression often boils down to “is it you, or is me?” Is reduction quality candidates, fact that there are now too many candidates for rapidly shrinking pool jobs? Australia provides an ideal case study, as large and decentralized country with government mandate build STEMM (Science, Technology, Engineering, Mathematics Medicine) workforce. The goal present study was 1) provide baseline experiences...

10.1057/palcomms.2016.93 article EN cc-by Palgrave Communications 2016-12-13

In the field of melanoma, clinical trials evaluating impact sentinel node biopsy, completion lymph dissection and adjuvant medical therapies on patient outcomes have provided evidence that has changed practice significantly over past five years.The aim this article is to discuss key informed new Cancer Council Australia melanoma management guidelines.General practitioners play a critical role in diagnosis follow-up. Complete excisional biopsy achieve accurate tumour microstaging essential...

10.31128/ajgp-02-20-5238 article EN cc-by Australian Journal of General Practice 2020-11-01

Academic, medical, and research communities are struggling to quickly effectively address unethical conduct within their professional ranks. Without a policy in place, individuals institutes subject convoluted procedures unnecessary consequences. In addition policies geared prevent harassment assault, it is important protect the ethical basis for provide set of guidelines how professionals treat each other, students, trainees. Since drafting this nature complex, 10 provided as framework...

10.3390/admsci6040016 article EN cc-by Administrative Sciences 2016-11-24

Centers for Disease Control and Prevention (CDC), health departments, other state federal partners have linked contact with live poultry to 70 human Salmonella outbreaks in the United States from 2000 2017, which resulted a total of 4,794 illnesses, 894 hospitalizations, 7 deaths. During salmonellosis environmental sampling is rarely conducted as part outbreak investigation. CDC was contacted by officials on June 12, 2018, provide support during an investigation risk factors infections...

10.3382/ps/pez529 article EN cc-by-nc-nd Poultry Science 2019-10-03

Our paper describes the introduction of large fragments both human heavy and light chain Ig genes into mouse germline to create a strain capable producing broad repertoire antigen-specific, fully antibodies. The immunoglobulin gene sequences were functional in context machinery for antibody recombination expression, either presence or absence endogenous genes. This was demonstrated by their ability undergo diverse rearrangement, be expressed at significant levels, exclude expression...

10.1111/j.1749-6632.1995.tb55878.x article EN Annals of the New York Academy of Sciences 1995-09-01

Antimicrobial resistance has rendered certain species of Mycobacterium difficult to treat clinically, particularly the nontuberculous and abscessus. While veterinary medicine human share many classes antibiotics, there are several antibiotics which uniquely licensed but not medicine. It was, therefore, aim this study examine action eight a population multi- pan-resistant M. abscessus, isolated from sputum patients with cystic fibrosis (CF).Antibiotic susceptibility studies were performed on...

10.4103/ijmy.ijmy_73_18 article EN cc-by-nc-sa International Journal of Mycobacteriology 2018-01-01

Obstructive sleep apnoea (OSA) affects up to 28 % of the adult population in Western countries. The detection and management OSA by general practitioners (GPs) can be poor. study aimed examine what influence enhanced invitations had on uptake on-line learning modules for GPs, whether recent referrals patients specialists influenced uptake. Practicing GPs regional Australia were identified randomised receive either an or standard invitation letter a new education module OSA. included...

10.1186/s13104-016-2157-5 article EN cc-by BMC Research Notes 2016-07-19

The lack of a representative scientific workforce is challenge being addressed by federal agencies, funding bodies, and research institutes. As organizational units emphasize the work training, recruiting, retaining, promoting an inclusive body, issues around bias metrics appear frequently in literature. goal this manuscript to introduce some most commonly misunderstood areas bias, ways adjust hiring promotion practices; focus on innovative quantify outputs through other than journal impact...

10.1093/aesa/sax059 article EN Annals of the Entomological Society of America 2017-06-28

ABSTRACT Two scaffolding proteins orchestrate ϕX174 morphogenesis. The internal protein B mediates the formation of pentameric assembly intermediates, whereas external D organizes 12 these intermediates into procapsids. Aromatic amino acid side chains mediate most coat-internal interactions. One residue in and three coat constitute core binding cleft. gene codons were randomized separately to ascertain chemical requirements encoded acids morphogenetic consequences mutation. resulting mutants...

10.1128/jvi.01384-17 article EN Journal of Virology 2017-10-05
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