A5101837173- Prostate Cancer Treatment and Research
- Adrenal and Paraganglionic Tumors
- Prostate Cancer Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Urologic and reproductive health conditions
- Epigenetics and DNA Methylation
- Renal and Vascular Pathologies
- Electric Motor Design and Analysis
- RNA Research and Splicing
- Magnetic Bearings and Levitation Dynamics
- Diabetes and associated disorders
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Research in Cotton Cultivation
- Plant and Fungal Interactions Research
- Kruppel-like factors research
- Connexins and lens biology
- Magnetic Properties and Applications
- Intestinal Malrotation and Obstruction Disorders
- Wnt/β-catenin signaling in development and cancer
Peking Union Medical College Hospital
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Nanjing University of Posts and Telecommunications
2024
Academy of Medical Sciences
2021-2022
Weatherford College
2019
Creative Commons
2017-2019
Zhejiang A & F University
2019
Shandong First Medical University
2014
Prostate cancer (PCa) is one of the major men malignancies worldwide. Long noncoding RNAs (lncRNAs) have been reported as essential regulators in human cancers, including PCa. In present study, lncRNA forkhead box P4 antisense RNA 1 (FOXP4-AS1) was found to be highly expressed TCGA PCa samples. Upregulation FOXP4-AS1 further validated 64 tissues and predicted poor prognosis patients with Functionally, high level associated increased cell proliferation decreased apoptosis, indicating that...
Abstract Objective Adrenal hemangioma (AH) is a rare, benign adrenal tumor often detected incidentally by imaging. This retrospective study aimed to investigate the clinical characteristics of AH, including and diagnostic imaging features, improve recognition understanding AH. Methods We retrospectively analyzed medical records patients diagnosed with AH at Peking Union Medical College Hospital between 2008 2022. Clinical manifestations, hormone levels, findings, treatment approaches,...
Background We previously described the enrichment of plasma exosome metabolites in CRPC, PCa, and TFC cohorts, found significant differences pyrimidine metabolites. The PMGs is associated with clinical prognosis several cancers, but its biological role PCa still unclear.
Purpose: Open adrenalectomy (OA) remains the gold standard of surgical therapy for adrenocortical carcinoma, while role laparoscopic approach is controversial. We aim to explore influence approaches on oncologic prognosis carcinoma by comparing short-term outcomes patients undergoing OA with those (LA). Patients and methods: retrospectively analyzed baseline characteristics, perioperative data 42 diagnosed stage I–III receiving (n=22) LA (n=20) as primary therapy. The end point was first...
Abstract Background Emerging evidence has implied the importance of long non‐coding RNAs in cancer development, including prostate (PCa). Bioinformatic analyses have identified that ADAMTS9‐AS1 may play a role progression. Methods A quantitative real‐time polymerase chain reaction was conducted to measure expression level at messenger RNA level. In vitro functional were performed investigate cell behaviors status under different conditions. Moreover, rescue assays explore potential...
Prostate cancer (PCa) is the most prevalent among males. This study attempted to develop a clinically significant prostate (csPCa) risk nomogram including Imaging-Reporting and Data System (PI-RADS) score other clinical indexes for initial biopsy in light of different regions, internal validation was further conducted.A retrospective performed 688 patients who underwent ultrasound-guided transperineal magnetic resonance imaging fusion from December 2016 July 2019. We constructed nomograms...
Purpose.: Cataract-microcornea syndrome (CCMC) is an autosomal dominant inherited disease characterized by the association of congenital cataract and microcornea without any other systemic anomaly or dysmorphism. Although mutations several genes have been shown to cause CCMC, in many patients causative gene has not yet identified. Our aim was identify disease-associated Chinese with CCMC. Methods.: The CCMC from two unrelated families 26 sporadic were enrolled. All screened Sanger sequencing...
Accumulating evidence has revealed the critical roles of long noncoding RNAs (lncRNAs) in various cancers. LncRNA SNHG20 been shown to be a cancer-associated lncRNA several cancers with diverse mechanisms. However, clinical references, biological roles, and mechanisms action prostate cancer (PCa) are still unclear.The expression PCa tissues cell lines was detected by RT-qPCR. The correlations between clinicopathological features were analyzed χ2 test. proliferation migration CCK-8, EdU...
J Clin Hypertens (Greenwich) . 2012;14:802–805. ©2012 Wiley Periodicals, Inc. Recurrent cerebral hemorrhages caused by hypertension secondary to reninoma are extremely rare in children. Because of its detrimental effects on children’s health, the importance early diagnosis and treatment for should be emphasized. Here, authors present a 10‐year‐old boy with intermittent headaches neurologic deficiency symptoms hypertension. A right kidney was detected successfully treated laparoscopic partial...
Background: Renal cell carcinoma metastasizing to rectum is very rare, and the unusual metastatic sites should be paid attention during follow-up of renal carcinoma. Case summary: We describe a case 65-year-old male who was diagnosed with 10 years after right radical nephrectomy. Histopathology immunohistochemical examinations contribute making differential diagnosis between rectal metastasis primary clear Positron emission tomography-computed tomography fluorodeoxyglucose shows...
Abstract Background Prostate cancer is the second most common in men, and some new target genes are needed to predict risk of prostate progression treatment. Methods In this study, effects UAP1L1 (UAP1-like-1) on were investigated by detecting proliferation, migration, invasion apoptosis cells vitro using MTT, wound healing, Transwell flow cytometry assay, tumor growth vivo. The downstream pathways explored Ingenuity Pathway Analysis (IPA), screened qRT-PCR western blot. CDCA8 also verified...
Pheochromocytoma and paraganglioma (PHEO-PGL) cyanotic congenital heart disease (CCHD) are both rare diseases. We reported a 30-year-old patient with right adrenal gland nodule retroperitoneal mass history of functional single atrium ventricle. 123I-metaiodobenzylguanidine scintigraphy showed intense uptake in lesions. Laboratory investigation demonstrated elevated urinary norepinephrine. Preoperative α-blockade was initiated. A successful open resection masses performed. Pathological...
DNA methylation alterations play important roles in initiation and progression of clear cell renal carcinoma (ccRCC). In this study, we attempted to identify differentially methylated mRNA signatures with prognostic value for ccRCC.The expression profiling data 306 ccRCC tumors were downloaded from The Cancer Genome Atlas (TCGA) screen lncRNAs mRNAs (DMLs DMMs) between bad good prognosis patients. Uni- multivariable Cox regression analyses LASSO Cox-PH analysis used select mRNAs....
There has been no research on applying gene detection to differential diagnosis of adrenocortical carcinoma (ACC). We attempted explore a novel auxiliary method for between ACC with benign adenoma (ACA), based mutations target genes in tissues. Nine were chosen as genes, including TP53, CTNNB1, ARMC5, PRKAR1A, ZNRF3, RB1, APC, MEN1, and RPL22. Exons sequencing performed 98 cases tissue samples by FastTarget technology, 41 tissues, 32 ACA 25 normal adrenal gland Significant detected...
In the traditional control scheme of a 12/8-pole bearingless switched reluctance motor (BSRM), radial force and torque are usually controlled as compromise due to conflict between their effective output areas. Additionally, each phase requires individual power circuits is excited in turn produce continuous levitation force, resulting high device requirements controller costs. This paper discusses single-winding hybrid-rotor (HBSRM) with hybrid rotor consisting cylindrical salient-pole...
<title>Abstract</title> Background. B cells play a critical role in protecting against infections. Decreased cell number, altered phenotype and function were found from patients with sepsis/septic shock, however, the underlying molecular mechanisms not elucidated. In present study, we aimed to explore composition, gene expressions receptor (BCR) characterization septic shock. Methods. isolated peripheral blood of shock healthy controls (HCs). Bulk RNA sequencing, single-cell BCR sequencing...