A5052062225- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- COVID-19 diagnosis using AI
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Family and Patient Care in Intensive Care Units
- Sarcoidosis and Beryllium Toxicity Research
- Sepsis Diagnosis and Treatment
- Air Quality Monitoring and Forecasting
- Machine Learning in Healthcare
- Long-Term Effects of COVID-19
- Cardiac Imaging and Diagnostics
- Amyloidosis: Diagnosis, Treatment, Outcomes
- COVID-19 Impact on Reproduction
- COVID-19 epidemiological studies
- RNA Interference and Gene Delivery
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Ultrasound in Clinical Applications
- Autoimmune Bullous Skin Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA regulation and disease
- Time Series Analysis and Forecasting
- Acute Kidney Injury Research
Icahn School of Medicine at Mount Sinai
2020-2025
Mount Sinai Hospital
2020-2022
Mount Sinai Hospital
2020-2021
Cardiovascular Institute of the South
2021
Northwell Health
2011-2012
University of Bristol
2012
Feinstein Institute for Medical Research
2012
Ochsner Medical Center
2011
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a new human with few effective treatments1. Convalescent plasma, donated persons who have recovered from COVID-19, the acellular component of blood that contains antibodies, including those specifically recognize SARS-CoV-2. These when transfused into patients infected SARS-CoV-2, are thought to exert an antiviral effect, suppressing virus replication before mounted their own...
Approximately 20-30% of patients with COVID-19 require hospitalization, and 5-12% may critical care in an intensive unit (ICU). A rapid surge cases severe will lead to a corresponding demand for ICU care. Because constraints on resources, frontline healthcare workers be unable provide the frequent monitoring assessment required all at high risk clinical deterioration. We developed machine learning-based prioritization tool that predicts transfer within 24 h, seeking facilitate efficient use...
Background Since December 2019, Coronavirus Disease 2019 (COVID-19) has become a global pandemic, causing mass morbidity and mortality. Prior studies in other respiratory infections suggest that convalescent plasma transfusion may offer benefit to some patients. Here, the outcomes of thirty-nine hospitalized patients with severe life-threatening COVID-19 who received were compared against cohort retrospectively matched controls. Methods Plasma recipients selected based on supplemental oxygen...
Objectives: To examine whether increasing time between admission and intubation was associated with mortality in patients coronavirus disease 2019 who underwent mechanical ventilation. Design: Retrospective cohort study of severe acute respiratory syndrome 2 infection were admitted January 30, 2020, April ventilation prior to May 1, 2020. Patients followed up through August 15, Setting: Five hospitals within the Mount Sinai Health System New York City, NY. Patients: Adult Interventions:...
The third wave of COVID-19 is unique in that vaccines have been widely available; however, the highly transmissible Delta variant has predominant strain. Temporal changes hospitalized patient characteristics should continue to be analyzed as progresses.Compare demographics and outcomes patients during New York City's first two waves.Retrospective cohort study across five hospitals within Mount Sinai Health System, a quaternary academic medical system City. Participants were adult inpatients...
Background Early prediction of the need for invasive mechanical ventilation (IMV) in patients hospitalized with COVID-19 symptoms can help allocation resources appropriately and improve patient outcomes by monitoring treating at greatest risk respiratory failure. To complexity deciding whether a needs IMV, machine learning algorithms may bring more prognostic value timely systematic manner. Chest radiographs (CXRs) electronic medical records (EMRs), typically obtained early admitted...
Acute hypoxemic respiratory failure is the major complication of coronavirus disease 2019, yet optimal support strategies are uncertain. We aimed to describe outcomes with high-flow oxygen delivered through nasal cannula and noninvasive positive pressure ventilation in 2019 acute identify individual factors associated failure.Retrospective cohort study rates and/or success (live discharge without endotracheal intubation). Fine-Gray subdistribution hazard models were used patient...
Human immunodeficiency virus (HIV)-1 has been reported to cause tubular cell injury both in vivo and vitro studies. In the present study, we evaluated role of oxidative stress induction apoptosis HIV gene expressing mouse cells (Tg26, a transgenic model HIV-associated nephropathy) (tubular were transduced with pNL4-3: ΔG/P-GFP, VSV.G psueudo typed virus) Although Tg26 mice showed enhanced reactive oxygen species (ROS) generation apoptosis, renal tissue did not display robust antioxidant...
Abstract Purpose Intravenous fluids are mainstay of management acute kidney injury (AKI) after sepsis but can cause fluid overload. Recent literature shows that restrictive strategy may be beneficial in some patients with AKI, however, identifying these is challenging. We aimed to develop and validate a machine learning algorithm identify who would benefit from strategy. Methods included developed AKI within 48 hours ICU admission defined as receiving <500mL 24 AKI. Our primary outcome...
Abstract Objectives Mortality risk scores, such as SOFA, qSOFA, and CURB-65, are quick, effective tools for communicating a patient’s prognosis guiding therapeutic decisions. Most use simple calculations that can be performed by hand. While several COVID-19 specific scores exist, they lack the ease of these simpler scores. The objectives this study were (1) to design, validate, calibrate simple, easy-to-use mortality score patients (2) recalibrate CURB-65 in hospitalized population. Design...
Background: The coronavirus disease 2019 (COVID-19) pandemic resulted in a surge of critically ill patients. This was especially true New York City. We present roadmap for hospitals and healthcare systems to prepare Pandemic.Methods: retrospective review how Mount Sinai Hospital (MSH) able rapidly handle the pandemic. MSH, largest academic hospital within Health System, expanded intensive care unit (ICU) bed capacity, including creating new ICU beds, workforce, created guidelines.Results:...
Coronavirus disease 2019 has been a worldwide pandemic since early 2020 with New York City being the epicenter in United States during 2020. Although cases of decreased coronavirus summer, began to rise once more fall-winter period. Little is known about trends patient characteristics, medical care, and outcome between these time periods. We report initial characteristics outcomes from large quaternary referral center Spring (March June), Summer (July September), Winter (October December),...
We aim to describe the demographics and outcomes of patients with severe disease Omicron variant. The acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus continues mutate, availability vaccines boosters continue rise, it is important understand health care burden new variants. analyze admitted intensive units (ICUs) in a large Academic Health System during New York City's fourth surge beginning on November 27, 2021.All an ICU were included primary analysis. Key retrospectively...
ABSTRACT Rationale Acute hypoxemic respiratory failure (AHRF) is the major complication of coronavirus disease 2019 (COVID-19), yet optimal support strategies are uncertain. Objectives To describe outcomes with high-flow oxygen delivered through nasal cannula (HFNC) and non-invasive positive pressure ventilation (NIPPV) in COVID-19 AHRF identify individual factors associated failure. Methods We performed a retrospective cohort study hospitalized adults treated HFNC and/or NIPPV to rates...
Background: New York City was the epicenter of initial surge COVID-19 pandemic in United States. Tracheostomy is a critical procedure care patients with COVID-19. We hypothesized that early tracheostomy would decrease length time on sedation, mechanical ventilation, intensive unit stay, and mortality. Methods: A retrospective analysis outcomes for all who underwent during first year at Mount Sinai Hospital City, York. All adult units Hospital, Patients/subjects: 888 admitted to Results:...
The decision to extubate patients on invasive mechanical ventilation is critical; however, clinician performance in identifying liberate from the ventilator poor. Machine Learning-based predictors using tabular data have been developed; these fail capture wide spectrum of available. Here, we develop and validate a deep learning-based model routinely collected chest X-rays predict outcome attempted extubation. We included 2288 serial admitted Medical ICU at an urban academic medical center,...