A5032871803- Gut microbiota and health
- Immune Response and Inflammation
- interferon and immune responses
- Influenza Virus Research Studies
- Tryptophan and brain disorders
- Clostridium difficile and Clostridium perfringens research
- Immune Cell Function and Interaction
- Pharmacological Effects of Natural Compounds
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- MicroRNA in disease regulation
- Head and Neck Cancer Studies
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Berberine and alkaloids research
- Sleep and Wakefulness Research
- Gout, Hyperuricemia, Uric Acid
- Neonatal Respiratory Health Research
- Hepatitis B Virus Studies
- Ultrasound and Hyperthermia Applications
- Acne and Rosacea Treatments and Effects
- Inflammatory Bowel Disease
- Vestibular and auditory disorders
- Lung Cancer Diagnosis and Treatment
Jinan University
2015-2024
Jiangnan University
2024
Guangzhou Medical University
2021-2023
Guangzhou Institute of Dermatology
2013-2023
Guangzhou University of Chinese Medicine
2019-2022
Second Affiliated Hospital of Guangzhou Medical University
2021
Jinan University
2015
Indiana University School of Medicine
2015
Ruijin Hospital
2010
The morbidity associated with cancer has rapidly increased in recent years, and the previous 5 years had a tendency to be leading cause of fatality compared cardiovascular disease. Therefore, effective measures are required an aim reduce incidence. Based on results clinical investigation, multidisciplinary treatment strategy for cancer, which includes radiotherapy, chemotherapy, surgery, targeted therapy immunotherapy, prominently used practice. However, therapies insufficient due multidrug...
Poria cocos polysaccharides (PCP) have been validated for several biological activities, including antitumor, anti-inflammatory, antioxidant, immunomodulatory, hepatoprotective and modulation on gut microbiota. In this research, we aim to demonstrate the potential prebiotic effects therapeutic efficacies of PCP in treatment antibiotic-associated diarrhea (AAD), confirm beneficial dysbiosis. Antibiotic-associated mice models were established by treating them with broad-spectrum antibiotics...
Abstract Climate and environmental changes threaten human mental health, but the impacts of specific conditions on neuropsychiatric disorders remain largely unclear. Here, we show impact a humid heat environment brain gut microbiota using conditioned housing male mouse model. We demonstrate that can cause anxiety-like behaviour in mice. Microbial 16 S rRNA sequencing analysis reveals caused dysbiosis (e.g., decreased abundance Lactobacillus murinus ), metabolomics an increase serum levels...
Berberine, a natural isoquinoline alkaloid isolated from the berberis species, has wide array of biological properties such as anti-inflammatory, antibacterial, antifungal, and antihelminthic effects. We evaluated antiviral effect berberine against influenza A/FM1/1/47 (H1N1) in vivo vitro. The results showed that strongly suppressed viral replication A549 cells mouse lungs. Meanwhile, relieved pulmonary inflammation reduced necrosis, inflammatory cell infiltration, edema induced by...
Influenza in humans is often accompanied by gastroenteritis-like symptoms. GeGen QinLian decoction (GQD), a Chinese herb formula, has been widely used to treat infectious diarrhea for centuries and the effect of restoring intestinal flora. Studies have also reported that GQD were patients with influenza. However, whether regulating flora one ways treats influenza not confirmed. In present research, we conducted systemic pharmacological study, results showed may acts through multiple targets...
Objective: The objective of this study was to observe the effects forsythoside A on controlling influenza virus (IAV) infection and improving prognosis IAV infection. Methods: Forty-eight SPF C57BL/6j mice were randomly divided into following four groups: Group A: normal control group (normal con); B: (V C: IAV+ oseltamivir treatment oseltamivir; 0.78 mg/mL, 0.2 mL/mouse/day); D: FTA; 2 μg/mL, mL/mouse/day). Real-time fluorescence quantitative PCR (RT-qPCR) used measure mRNA expression TLR7,...
Sepsis, a life-threatening condition whereby immune dysregulation develops, is one of the major causes death worldwide. To date, there still no clinically effective therapeutic method for sepsis. As natural product from traditional Chinese medicine, Shikonin has been demonstrated to have pleiotropic medical effects, including anti-tumor, anti-inflammation, and relieving PD-L1, as receptor PD-1, was also involved in exacerbating sepsis by inducing immunosuppression, but relationship between...
The objective of this study is to investigate the effects baicalin on controlling pulmonary infection and improving prognosis in influenza A virus (IAV) infection. PCR western blot were used measure changes some key factors RLRs signaling pathway. MSD electrochemiluminescence was expression inflammatory cytokines including IFN-γ, TNF-α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p70, KC/GRO. Flow cytometry detect proportion Th1, Th2, Th17, Treg. results showed that IAV led low body weight...
Herein, we demonstrate baicalin-loaded selenium nanoparticles with a liver-targeting folic acid moiety to treat HBV-infected liver cancer.
Abstract Sepsis is a systemic inflammatory response that may be induced by trauma, infection, surgery, and burns. With the aim of discovering novel treatment targets for sepsis, this current study was conducted to investigate effect potential mechanism which microRNA‐30a (miR‐30a) controls sepsis‐induced liver cell proliferation apoptosis. Rat models sepsis were established applying cecal ligation puncture (CLP) method simulate models. The binding site between miR‐30a suppressor cytokine...
Influenza virus is a single-stranded RNA that causes influenza in humans and animals. About 600 million people around the world suffer from every year. Upon recognizing viral molecules, TLR7 (Toll-like receptor) initiates corresponding immune responses. Traditional Chinese Medicines (TCMs), including Yinqiao powder, Xinjiaxiangruyin Guizhi-and-Mahuang decoction, have been extensively applied clinical treatment of influenza. Although therapeutic efficacy TCMs against vivo was reported...
Gout is a common disease with high incidence due to unhealthy diet and living habits. Simiao Powder, as classic formula consisted of four herbs, has been widely used in clinical practice since ancient times prevent treat gout. However, the pharmacological mechanism Powder still unclear.Based on network pharmacology, active compounds were identified TCMSP, ETCM BATMAN database, establish interaction between potential targets known therapeutic Subsequently, key are being for protein-protein...
Ulcerative colitis (UC) is characterized by chronic relapsing intestinal inflammation. Currently, there no effective treatment for the disease. According to our preliminary data, 1,8-cineole, which main active compound of Amomum compactum Sol. ex Maton volatile oil and an drug pneumonia, showed remarkable anti-inflammatory effects on pathogenesis. However, its mechanism action direct targets remain unclear. This study investigated through 1,8-cineole exerts using a dextran sulfate sodium...
Background There is growing evidence of associations between the gut microbiota and anxiety disorders, where changes in microbiotas may affect brain function behavior via microbiota-gut-brain axis. However, population-level studies offering a higher level for causality are lacking. Our aim was to investigate specific associated metabolites that closely related disorders provide mechanistic insights novel management perspectives disorders. Method This study used summary-level data from...
There have been some reports implicating the pharmacologic action of Dihydrosanguinarine (DHSA), but little research including effects it on cancer cells. PANC-1 cells mutations in K-Ras and TP53, which respectively express mutant p53 protein, Ras/p53 believed with closely relationship to occurrence various tumors.To reveal inhibition pancreatic (PANC-1 SW1990) proliferation by inducing G0/G1 G2/M phase arrest via downregulation mut-p53 apoptosis inhibiting invasiveness through Ras/Mek/Erk...
In recent years, Gegen Qinlian decoction (GQD) has been applied to treat influenza virus infection, and its clinical effectiveness shown. However, the potential mechanism by which GQD acts on A (IAV) not fully elucidated. Traditional Chinese medicine (TCM) formulas are well known have multiple targets effects. Our previous experiments examined TCM can be used from perspective of immune mechanism.To explore possible affects mice infected with FM1 strain virus.Forty-eight C57BL/6 were divided...