A5101623193- Pain Mechanisms and Treatments
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Healthcare and Venom Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Neuroprotection
- Ion Channels and Receptors
- Tryptophan and brain disorders
- Acupuncture Treatment Research Studies
- Medical Research and Treatments
- Cardiac Ischemia and Reperfusion
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Metabolomics and Mass Spectrometry Studies
- Stress Responses and Cortisol
- Ideological and Political Education
- Circadian rhythm and melatonin
- Toxin Mechanisms and Immunotoxins
- Nitric Oxide and Endothelin Effects
- Traumatic Brain Injury and Neurovascular Disturbances
- Medicinal Plants and Bioactive Compounds
- Cancer, Stress, Anesthesia, and Immune Response
- Food Quality and Safety Studies
- Neurological Disease Mechanisms and Treatments
Qingdao University of Science and Technology
2025
State Key Laboratory of Chemical Engineering
2025
Fudan University
2025
Jinan University
2015-2024
Beijing Technology and Business University
2024
Nanjing Jiangning Hospital
2023
Jiangmen Central Hospital
2011
Nanjing University
2006
International Space Science Institute - Beijing
1998
Kyushu University
1998
Switching microglial polarization from the M1 to M2 phenotype is a promising therapeutic strategy for neuropathic pain (NP). Toll-like receptor 4 (TLR4) activated by lipopolysaccharide (LPS). Uncontrolled activation of TLR4 has been proven trigger chronic inflammation. Kaempferol, dietary flavonoid, known have anti-inflammatory properties. This study aimed investigate analgesic and effects underlying mechanisms kaempferol, which were explored with an NP model in vivo LPS-induced injury BV2...
Abstract Background This study aimed to investigate the potential mechanism of paeonol in treatment neuropathic pain. Methods Relevant mechanisms were explored through microglial pseudotime analysis and use specific inhibitors cell experiments. In animal experiments, 32 SD rats randomly divided into sham operation group, chronic constrictive injury (CCI) ibuprofen group. We performed behavioral testing, ELISA, PCR, Western blotting, immunohistochemistry, immunofluorescence analysis. Results...
Abstract Aims This study aimed to investigate the potential therapeutic applications of stigmasterol for treating neuropathic pain. Methods Related mechanisms were investigated by DRG single‐cell sequencing analysis and use specific inhibitors in cellular experiments. In animal experiments, 32 male Sprague–Dawley rats randomly divided into sham operation group, CCI ibuprofen group. We performed behavioral tests, ELISA, H&E staining immunohistochemistry, western blotting. Results Cell...
Constructing an efficient open hollow nut-like Co-MOF/Pt-based electrocatalyst via a partial etching strategy remains challenging. In this study, novel concurrent thermal polymerization-etching is introduced to prepare unique Co-PtSA decorated with CoPt@C layer (denoted as Co-PtSA/CoPt@C), exhibiting outstanding hydrogen evolution reaction performance. Co-PtSA/CoPt@C, the distinctive structure encapsulated within layer. The consists of CoPt@CNTs and core-shell. Electrochemical tests...
<title>Abstract</title> Microbial biosynthetic diversity holds immense potential for discovering natural products with therapeutic applications, yet a substantial quantity of derived from uncultivated microorganisms remains uncharacterized. The intricate nature enzymes poses major challenge in accurately predicting the chemical structures secondary metabolites solely based on genome sequences using current rule-based methods. Here, we present DeepSeMS, large language model designed to...
The research tries to establish Wistar rat’s model of atherosclerosis for evaluating the antiatherosclerotic effect hederagenin and exploring its antiatherosclerosis-related mechanisms. statistical data have shown that exhibits multiple pharmacological activities in treatment hyperlipidemia, antiplatelet aggregation, liver protection, anti-inflammation, indicating may exert a protective on vascular walls by improving lipid metabolism disorders deposition. results show can correct imbalance...
Abstract Therapeutic drugs of chronic neuralgia have a high risk addiction, making it crucial to identify novel for neuralgia. This study aimed explore the therapeutic effect paeoniflorin on sciatica via inhibiting Schwann cell apoptosis. 28 SD rats were randomly divided into four groups, including sham operation group, constriction injury (CCI) mecobalamin and group. The mechanism evaluated rat experiments. Mechanical, hot, or cold hyperalgesia was induced in after CCI operation, while...
This study explored the therapeutic effect of α-asarone on chronic sciatica. Thirty-two Sprague-Dawley (SD) rats were divided into four groups: sham group, constriction injury (CCI) pregabalin and group. Hot hyperalgesia was induced after CCI operation, found to relieve neuralgia. Furthermore, reduced IL1β, IL6, TNF-α, CRP, LPS levels increased IL10 in serum. α-Asarone decreased protein TRPA1, TRPM8, TRPV1-4 mRNA TRPV1-4, TNF-α dorsal root ganglion neurons. In sciatic nerve, treatment number...
1. Icaritin is a natural flavonoid with anti-osteoporosis activity. This study aimed to characterize icaritin glucuronidation by pooled human liver microsomes (HLM) and intestine (HIM), determine the contribution of individual UDP-glucuronosyltrans-ferase (UGT) enzyme glucuronidation. 2. Glucuronidation rates were determined incubating uridine diphosphate glucuronic acid (UDPGA)-supplemented microsomes. Kinetic parameters derived appropriate model fitting. Relative activity factors...
Hederagenin is one of the main components Tetrapanax papyriferus, and papyriferus ingredients Danggui Sini decoction. To explore whether hederagenin can alleviate mechanical pain, thermal hyperalgesia, cold pain at same time, we comprehensively investigated effects two drugs on levels p38 MAPK phosphorylation, TRP proteins, IL1β, IL6, TNF-α in serum.Firstly, obtained pain-related targets performed KEGG pathway enrichment these targets. Then, 42 SD rats were separated randomly into six...
Oxidative stress damage is known as one of the important factors that induce neuropathic pain (NP). Using antioxidant therapy usually achieves an obvious curative effect and alleviates NP. Previous pharmacological studies have shown higenamine (Hig) performs to be anti-inflammatory. However, protective mechanism Hig on NP are still unclear. This study mainly evaluated changes in reactive oxygen species (ROS) level, lipid peroxidation, system composed superoxide dismutase (SOD) glutathione...
Abstract (Switching from the microglial M1 phenotype to M2 is a promising therapeutic strategy for neuropathic pain (NP). This study aimed investigate potential use of stigmasterol treating NP. In animal experiments, 32 male Sprague–Dawley rats were randomly divided into sham operation group, chronic constriction injury (CCI) CCI + ibuprofen and group. We performed behavioral tests, enzyme‐linked immunosorbent assay, hematoxylin‐esoin staining (H&E) immunohistochemistry,...
The aim of this study was to find an effective drug cocktail pretreatment protect myocardial tissue the heart from ischemia-reperfusion (I/R) injury. mechanisms underlying effects were subsequently explored in order expand application Dang-gui-si-ni-tang (DGSN), a Traditional Chinese Medicine. active components DGSN serum following oral administration investigated using high-performance liquid chromatography. activity superoxide dismutase (SOD) and malondialdehyde (MDA) levels then analyzed...
The aim of the present study was to assess protective effects 18β‑GA against hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)‑induced injury. First, SMILES annotation for used search PubChem and reverse molecular docking in Swiss Target Prediction, Similarity Ensemble Approach Search Server TargetNet database obtain potential targets. Injury‑related molecules were obtained from GeneCards predicted targets injury treatment selected by Wayne diagram analysis. Subsequently, Kyoto Encyclopedia...
Oxaliplatin is a widely used chemotherapeutic agent that induces both acute and chronic peripheral neuropathy. Based on previous research indicating estrogen replacement may attenuate some forms of pain in ovariectomized animals, we examined the effects 17β-estradiol OXAIPN. We discovered local cold exposure an abnormal vascular response models OXAIPN (oxaliplatin-induced neuropathy) be as easy non-invasive method to predict which patients susceptible development severe, Neuropathy was...