A5089530556- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Preterm Birth and Chorioamnionitis
- Sphingolipid Metabolism and Signaling
- Prenatal Screening and Diagnostics
- Erythrocyte Function and Pathophysiology
- Reproductive System and Pregnancy
- Biomarkers in Disease Mechanisms
- Connective tissue disorders research
- Acute Myocardial Infarction Research
- Blood Coagulation and Thrombosis Mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Immunodeficiency and Autoimmune Disorders
- Zebrafish Biomedical Research Applications
- Long-Term Effects of COVID-19
- Neonatal and Maternal Infections
- Diet and metabolism studies
- PARP inhibition in cancer therapy
- Rheumatoid Arthritis Research and Therapies
- Parvovirus B19 Infection Studies
- Retinoids in leukemia and cellular processes
- Gestational Diabetes Research and Management
- Infant Nutrition and Health
- Parathyroid Disorders and Treatments
Medical University of Białystok
2014-2024
Center for Rheumatology
2023
Copenhagen University Hospital
2019
Rigshospitalet
2019
Intramuscular accumulation of bioactive lipids leads to insulin resistance and type 2 diabetes (T2D). There is lack consensus concerning which the lipid mediators has greatest impact on muscle action in vivo Our aim was elucidate effects high-fat diet (HFD) metformin (Met) skeletal (IR) rats. We employed a [U-13C]palmitate isotope tracer mass spectrometry measure content fractional synthesis rate (FSR) intramuscular long-chain acyl-CoA (LCACoA), diacylglycerols (DAG) ceramide (Cer). Eight...
Introduction. Nowadays it is thought that the main cause of premature birth subclinical infection. However, none currently used methods provide effective prevention to preterm labor. The aim study was determine concentration selected chemokines in sera patients with without clinical signs infection (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>62</mml:mn></mml:math>), threatened labor...
The aim of the study was to analyse a panel 11 sphingolipids in plasma and three blood fractions (platelet-poor plasma, platelets red cells) women with mild preeclampsia.We recruited 21 between 25-40 weeks gestation diagnosed preeclampsia group 36 healthy uncomplicated pregnancies, who corresponded according gestational age, control group. To assess concentration fractions, we used ultra-high performance liquid chromatography coupled triple quadrupole mass spectrometry (UHPLC/MS/MS).We...
Objective. To profile maternal plasma metabolome in spontaneous preterm birth. Method. In this retrospective case-control study, we have examined of patient with birth (between 22 and 36 weeks pregnancy (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>57</mml:mn></mml:math>)), threatened labor 23 id="M2"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>49</mml:mn></mml:math>)), term delivery...
Introduction Sphingolipids can be potentially involved in the formation of central and peripheral nervous systems, which are particularly connected with pathogenesis Down syndrome. The aim study was to determine concentration selected sphingolipids plasma amniotic fluid pregnant patients fetal Material Methods Out 190 amniocentesis we had 10 confirmed For purpose our control chose 14 women without chromosomal aberration. To assess 11 blood used an ultra-high performance liquid chromatography...
Chemokines exert different inflammatory responses which can potentially be related to certain fetal chromosomal abnormalities. The aim of the study was determine concentration selected chemokines in plasma and amniotic fluid women with Down syndrome.Out 171 amniocentesis, we had 7 patients confirmed syndrome (15th-18th weeks gestation). For purpose our control, chose 14 without aberration. To assess blood fluid, used a protein macroarray, allows simultaneous determination 40 per sample.We...
Preeclampsia has the highest rate of obstetric morbidity and mortality.We recruited 21 women with preeclampsia 27 uncomplicated pregnancies. We used a quantitative protein macroarray that allowed for analysis 40 proteins.We found statistically significant increase in concentration DR3, LIF decrease VEGF, PlGF, syndecan-4 galectin-2, plasma preeclampsia.There are no previous studies assessing syndecan 4, galectin 2, DR3 concentrations preeclampsia; Our results indicate these proteins new...
Angiogenic factors are proteins that can potentially be related to certain foetal chromosomal abnormalities. The goal of this study was determine the concentrations 60 angiogenic in amniotic fluid women carrying foetuses with Down syndrome (DS).After analysis karyotyping results, for purpose study, we chose 12 DS. For control group, selected healthy patients uncomplicated pregnancies (15-18 weeks gestation) who delivered newborns at term. To assess fluid, used a protein macroarray, which...
Imbalance in the metabolites levels which can potentially be related to certain fetal chromosomal abnormalities stimulate mother’s immune response produce autoantibodies directed against proteins. The aim of study was determine concentration 9000 maternal plasma detect Down syndrome. Method. We performed 190 amniocenteses and found 10 patients with confirmed syndrome (15th–18th weeks gestation). For purpose our control we chose 11 women without aberration. To assess expression blood plasma,...
Objective and design Angiogenic factors are proteins that related to certain foetal chromosomal abnormalities. The aim of this study was determine the concentration 60 angiogenic in plasma women with offspring possessing trisomy 21/Down syndrome (DS). Method After analysing karyotyping results, we selected 20 patients foetuses DS, for control group, 28 healthy uncomplicated pregnancies who delivered newborns at term (i.e., 15–18 weeks gestation). To assess blood plasma, used a protein...
4-pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR) is a nicotinamide derivative, considered new oncometabolite. 4PYR formation induced cytotoxic effect on the endothelium. Elevated blood concentration was observed in patients with cancer. Still, little known about metabolic and functional effects of this pathology. The study aimed to investigate whether toxic accumulation may affect activity anticancer therapy cyclophosphamide orthotropic model breast Female Balb/c mice were injected 4T1...
The human HEPC-CB.1 cell line with many characteristics of endothelial progenitor cells (EPC) was tested for its proangiogenic properties as a potentially therapeutic compound. cells' potential to differentiate into revealed after treating the mixture ATRA, cAMP and VEGF, shown by reduced expression levels CD133, CD271 CD90 antigens, augmentation CD146 CD31, decrease in clonogenicity. cooperation HSkMEC.2 resulted formation common network. Tube significantly more effective when resulting...
Objectives A widely accepted treat-to-target strategy for rheumatoid arthritis (RA) requires the patient’s per-spective in making treatment decisions. However, data on preferences and expectations of Polish patients with RA are scarce. The aim study was to determine satisfaction nature therapeutic mod-erate severe RA. Material methods Fifty-two adult moderately highly active were asked complete pa-tient-reported outcomes patient-provided information questionnaires. Additionally, patient...
Background: The exact role of individual inflammatory factor in heart failure with reduced ejection fraction (HFrEF) remains elusive. study aimed to evaluate three monocyte subsets (classical-CD14++CD16−, intermediate-CD14++CD16+, and nonclassical-CD14+CD16++) HFrEF patients assess the effect cardiac resynchronization therapy (CRT) on changes compartment. Methods: included 85 stable HFrEF. Twenty-five them underwent CRT device implantation subsequent 6-month assessment. control group...
The aim of this review was discussion on the new protein and lipid factors their role in pathomechanism preeclampsia. Sphingolipids discussed review: Sph (sphingosine), S1P (sphingosine- 1-phosphate), C20-Cer (ceramides containing arachidic acid), C18-Cer stearic C16-Cer palmitic C18: 1-Cer oleic C22-Cer (ceramide behenic acid) C24: nervonic acid). Angiogenic Hb-EGF (heparin-binding EGF-like growth factor), HGF (hepatocyte LIF (leukaemia inhibitory leptin, PDGF-BB (platelet-derived factor...