A5040625666- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- Cancer-related gene regulation
- COVID-19 epidemiological studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Acute Lymphoblastic Leukemia research
- Ubiquitin and proteasome pathways
- Thyroid Cancer Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Protein Degradation and Inhibitors
- Renal Transplantation Outcomes and Treatments
- Immunotherapy and Immune Responses
- DNA Repair Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Biochemical and Molecular Research
- Cancer Genomics and Diagnostics
- Thyroid Disorders and Treatments
- Animal Genetics and Reproduction
- Prenatal Screening and Diagnostics
- Peptidase Inhibition and Analysis
- SARS-CoV-2 and COVID-19 Research
- RNA Research and Splicing
- Viral-associated cancers and disorders
Universitätsmedizin Göttingen
2019-2023
University of Göttingen
1996-2022
BACKGROUND Cell-free DNA (cfDNA) from grafts in the circulation of transplant recipients is a potential biomarker rejection. Its usefulness was investigated after heart transplantation during maintenance phase by use microarrays and massive parallel sequencing donor recipient DNA. Disadvantages these methods are high costs, long turnaround times, need for Therefore, we sought to develop rapid cost-effective method using digital droplet PCR (ddPCR). METHODS Plasma samples were collected...
Background: Thiopurine S-methyltransferase (TPMT) is an excellent example of enzyme whose pharmacogenetic polymorphisms affect efficacy and toxicity a drug. The association between TPMT activity thiopurine-related myelosuppression well recognized. To study the significance deficiency in thiopurine metabolism immunosuppressive vitro, we established RNA interference-based knockdown (kd) Jurkat cell line. Results: In kd cells, expression was reduced to 73% at level 83% protein level. cells were...
Hemophilia B is a classical monogenic, X-chromosomal, recessively transmitted bleeding disorder caused by genetic variants within the coagulation factor IX gene (F9). Although hemophilia has been described in dogs, it not yet reported Hovawart breed. Here we describe identification of family transmitting typical signs an X-linked disorder. Five males were to suffer from recurrent hemorrhagic episodes. A blood sample one these with only 2% normal concentration plasma together samples seven...
ever, all of the modifications that we have considered are significantly more complicated and would most likely result in a lower cloning efficiency.
Atherosclerosis is an important risk factor in the development of cardiovascular diseases. In addition to increased plasma lipid concentrations, irregular/oscillatory shear stress and inflammatory processes trigger atherosclerosis. Inhibitors transcription modulatory bromo- extra-terminal domain (BET) protein family (BETi) could offer a possible therapeutic approach due their epigenetic mechanism anti-inflammatory properties. this study, influence laminar stress, inflammation BETi treatment...
Despite recent advances in prophylactic vaccination, SARS-CoV-2 infections continue to cause significant morbidity. A better understanding of immune response differences between vaccinated individuals with and without later breakthrough infection is urgently needed. CoV-ADAPT a prospective long-term study comparing humoral (anti-spike-RBD-IgG, neutralization capacity, avidity) cellular (spike-induced T-cell interferon-γ [IFN-γ] release) responses against at four different time points (three...
Thyroid-stimulating hormone (TSH) is the routine primary screening test to assess thyroid function and rapid measurement of TSH levels highly desirable especially in emergency situations. In present study, we compared analytical performance a commercially available point-of-care (AFIAS-1) five laboratory-based systems.Left over material 60 patient plasma samples was collected from care used respective assay. For statistical analysis produced data Bland-Altman Passing-Bablok regression were...
Hemophilia B is a classical monogenic X-chromosomal recessively transmitted bleeding disorder caused by genetic variants within the coagulation factor IX gene (F9). Although hemophilia has been described in 32 dog breeds hitherto, it not yet reported Hovawart. Here we describe identification of Hovawart family transmitting typical signs an X-linked disorder. Five males had to suffer from recurrent hemorrhagic episodes, four them be euthanized finally and one died due severe blood loss. A...
Schütz,, E.; Wieland, Andag, R.; Armstrong, V. W.; Oellerich, M. Author Information