Hikari Otabi
A5065568461- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- GABA and Rice Research
- Child and Adolescent Psychosocial and Emotional Development
- Memory and Neural Mechanisms
- Mindfulness and Compassion Interventions
- Cardiac electrophysiology and arrhythmias
- Early Childhood Education and Development
- Neurotransmitter Receptor Influence on Behavior
- Attachment and Relationship Dynamics
- Nerve injury and regeneration
- Endoplasmic Reticulum Stress and Disease
- Gastrointestinal motility and disorders
- Child Abuse and Trauma
- Animal Genetics and Reproduction
- Bat Biology and Ecology Studies
- Gut microbiota and health
- Renin-Angiotensin System Studies
- Animal Behavior and Welfare Studies
- Genetics and Neurodevelopmental Disorders
Ibaraki University
2015-2024
Tokyo University of Agriculture and Technology
2020-2024
Kagawa University
2023-2024
Setsunan University
2021-2023
Lactate has diverse roles in the brain at molecular and behavioral levels under physiological pathophysiological conditions. This study investigates whether lysine lactylation (Kla), a lactate-derived post-translational modification macrophages, occurs cells if it does, Kla is induced by stimuli that accompany changes lactate levels. Here, we show regulated neural excitation social stress, with parallel These increase Kla, which associated expression of neuronal activity marker c-Fos, as...
Increased levels of lactate, an end-product glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These in lactate can result decreased brain pH, which has implicated patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed five mouse models schizophrenia, bipolar disorder, and autism, suggesting shared endophenotype among these disorders rather than mere artifacts due...
Early child maltreatment, such as abuse and neglect, is well known to affect the development of social skills. However, mechanisms by which an adverse environment interrupts skills remain unelucidated. Identifying period brain regions that are susceptible environments can lead appropriate developmental care later in life. We recently reported excitatory/inhibitory imbalance low activity during behavior medial prefrontal cortex (mPFC) maternal separation (MS) animal model early life neglect...
Increased levels of lactate, an end-product glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These in lactate can result decreased brain pH, which has implicated patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed five mouse models schizophrenia, bipolar disorder, and autism, suggesting shared endophenotype among these disorders rather than mere artifacts due...
We generated a knock-in mouse line in which the gene encoding brain-derived neurotrophic factor (Bdnf) was replaced with sequence for proBDNF containing human single nucleotide polymorphisms arginines proximal to cleavage site (R125M and R127L). The ratio of mature form BDNF (mBDNF) precursor (proBDNF) hippocampal tissue lysates decreased manner dependent on number copies mutant gene, indicating that mutations inhibited proteolytic conversion into mBDNF. Although homozygous mice had...
There have been high expectations in recent years of using xenotransplantation and regenerative medicine to treat humans, pigs utilized as the donor model. Pigs used for these clinical applications must be microbiologically safe, that is, free infectious pathogens, prevent infections not only livestock, but also humans. Currently, however, full spectrum pathogens can infect human host or cause disease transplanted porcine organs/cells has fully defined. In present study, we thus aimed...
Abstract Epidemiological studies have indicated that child maltreatment, such as neglect, is a risk factor of escalated aggression, potentially leading to delinquency and violent crime in the future. However, little known about mechanisms by which an early adverse environment may later cause behavior. In this study, we aimed thoroughly examine association between aggression against conspecific animals activity amygdala subnuclei using maternal separation (MS) model, common model life stress....
Nest building is an instinctive behavior toward protection from predators, body temperature regulation, and courtship. Previously, we discovered that acute chronic social defeat stress suppresses the onset of nest-building in male mice (C57BL/6J). Here, analyzed nest other behavioral deficits induced by (ASDS). We utilized a customized cage specifically developed observational programs for building, avoidance, behaviors using infrared depth camera to acquire three-dimensional (3D) data...
Increased levels of lactate, an end-product glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These in lactate can result decreased brain pH, which has implicated patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed five mouse models schizophrenia, bipolar disorder, and autism, suggesting shared endophenotype among these disorders rather than mere artifacts due...
Probiotics and prebiotics have become viable alternatives of growth-promoting antimicrobials in animal production. Here, we tested partially hydrolyzed guar gum (PHGG) as a possible prebiotic for piglets the commercial farm. Five hundred ninety-four were used experiments, with 293 given normal pig feed (control), while rest plus 0.06% (w/w) PHGG (PHGG). One three months post-PHGG supplementation, fecal samples collected from randomly selected 20 each group analyzed microbiota organic acid...
Abstract Lactate is known to have diverse roles in the brain at molecular and behavioral levels under both physiological pathophysiological conditions, such as learning memory regulation of mood. Recently, a novel post-translational modification called lysine lactylation has been found histone H3 mouse macrophages, paralleled intracellular lactate 1 . However, it unknown whether occurs cells, if does, induced by stimuli that accompany changes levels. Herein, we reveal cells regulated...
Stress contributes to mental disorders as well functional gastrointestinal disorders. In disorders, motility is thought play a role. Therefore, we evaluated the effects of chronic social defeat stress on in C57BL/6J mice, by measuring gastric emptying, fecal pellet output, and transit. mice subjected 10 days stress, serum corticosterone concentrations were significantly higher, relative tissue weights spleen adrenal gland tissues heavier, thymus sizes smaller than control mice. Stressed...
Lactate has diverse roles in the brain at molecular and behavioral levels under both physiological pathophysiological conditions. It is unknown whether a novel post-translational modification called lysine lactylation (Kla), recently discovered macrophages, occurs cells if it does, Kla induced by stimuli that accompany changes lactate levels. Herein, we reveal regulated neural excitation social stress, paralleled with These increased Kla, which were associated expression of neuronal activity...
Increased levels of lactate, an end-product glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These in lactate can result decreased brain pH, which has implicated patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed five mouse models schizophrenia, bipolar disorder, and autism, suggesting shared endophenotype among these disorders rather than mere artifacts due...
Increased levels of lactate, an end-product glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These in lactate can result decreased brain pH, which has implicated patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed five mouse models schizophrenia, bipolar disorder, and autism, suggesting shared endophenotype among these disorders rather than mere artifacts due...
社会的ストレスのような動物の個体間に生じるストレスは,様々な健康リスクを増加させる.我々は,マウスを実験モデルとして用いて,マウスの個体間におこる社会的ストレスが巣作り行動の遅延を引き起こすことを明らかにした.この巣作り遅延現象をうつ様症状の評価系として構築するために,簡易的な向精神薬スクリーニング方法の開発とその妥当性を評価した.また,赤外線深度センサを使用して社会的ストレスを受けたマウスの客観的および詳細な行動解析を行った.その結果,巣作り遅延は暗期の初期以降に徐々に軽減されていき,自発活動量の増加やリアリング行動の低下を示した.また,巣作り遅延と社会的忌避行動の間に正の相関にある傾向が示された.これらの研究は動物やヒトのストレス研究における基礎的なメカニズムを解明できる可能性があり,赤外線深度センサを使用した異常行動の検出は大型動物への応用が期待される.