Ryuhei Miyake
A5092122866- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- GABA and Rice Research
- Memory and Neural Mechanisms
- Cardiac electrophysiology and arrhythmias
- Phosphodiesterase function and regulation
- Electrolyte and hormonal disorders
- Renin-Angiotensin System Studies
- Genetics and Neurodevelopmental Disorders
- Renal function and acid-base balance
- Tryptophan and brain disorders
- Heart Rate Variability and Autonomic Control
- Stress Responses and Cortisol
RIKEN Center for Brain Science
2023-2024
Gunma University
2023
Increased levels of lactate, an end-product glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These in lactate can result decreased brain pH, which has implicated patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed five mouse models schizophrenia, bipolar disorder, and autism, suggesting shared endophenotype among these disorders rather than mere artifacts due...
Human genetics strongly support the involvement of synaptopathy in psychiatric disorders. However, trans-scale causality linking synapse pathology to behavioral changes is lacking. To address this question, we examined effects synaptic inputs on dendrites, cells, and behaviors mice with knockdown SETD1A DISC1, which are validated animal models schizophrenia. Both exhibited an overrepresentation extra-large (XL) synapses, evoked supralinear dendritic somatic integration, resulting increased...
Increased levels of lactate, an end-product glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These in lactate can result decreased brain pH, which has implicated patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed five mouse models schizophrenia, bipolar disorder, and autism, suggesting shared endophenotype among these disorders rather than mere artifacts due...
Increased levels of lactate, an end-product glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These in lactate can result decreased brain pH, which has implicated patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed five mouse models schizophrenia, bipolar disorder, and autism, suggesting shared endophenotype among these disorders rather than mere artifacts due...
Increased levels of lactate, an end-product glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These in lactate can result decreased brain pH, which has implicated patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed five mouse models schizophrenia, bipolar disorder, and autism, suggesting shared endophenotype among these disorders rather than mere artifacts due...
Major depressive disorder (depression) is a leading cause of disability. The severity depression affected by many factors, one which being comorbidity with diabetes mellitus (DM). DM major public health concern due to the high incidence both conditions and their mutually exacerbating pathophysiology. However, mechanisms exacerbates remain largely unknown, elucidating these regulatory would contribute significant unmet clinical need. We generated comorbid mouse model (comorbid model), was...
Increased levels of lactate, an end-product glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These in lactate can result decreased brain pH, which has implicated patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed five mouse models schizophrenia, bipolar disorder, and autism, suggesting shared endophenotype among these disorders rather than mere artifacts due...