Motoaki Fukasawa
A5087829084- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Metabolism and Genetic Disorders
- Ion channel regulation and function
- GABA and Rice Research
- Advanced Sensor and Energy Harvesting Materials
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sperm and Testicular Function
- Mitochondrial Function and Pathology
- Peroxisome Proliferator-Activated Receptors
- Memory and Neural Mechanisms
- Reproductive biology and impacts on aquatic species
- Textile materials and evaluations
- Optical Coherence Tomography Applications
- Maternal and Perinatal Health Interventions
- Neurogenesis and neuroplasticity mechanisms
- Renal function and acid-base balance
- Sexual Differentiation and Disorders
- Genetics and Neurodevelopmental Disorders
- Electrochemical Analysis and Applications
- Anatomy and Medical Technology
- Neuroinflammation and Neurodegeneration Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- RNA regulation and disease
- Cardiac electrophysiology and arrhythmias
Fujita Health University
2009-2024
Fujita Health University Hospital
2017-2022
Increased levels of lactate, an end-product glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These in lactate can result decreased brain pH, which has implicated patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed five mouse models schizophrenia, bipolar disorder, and autism, suggesting shared endophenotype among these disorders rather than mere artifacts due...
Increased levels of lactate, an end-product glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These in lactate can result decreased brain pH, which has implicated patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed five mouse models schizophrenia, bipolar disorder, and autism, suggesting shared endophenotype among these disorders rather than mere artifacts due...
Cholesterol side chain cleavage cytochrome P450 ( P450scc , Cyp11a ) is responsible for the first step in steroidogenesis, catalyzing conversion of cholesterol to prognenolone. To investigate differentiation steroid‐producing cells and function sex steroids during gonadal teleost fish, medaka Oryzias latipes ), we isolated full length cDNA analyzed expression pattern mRNA development using situ hybridization. At hatching, just after initiation morphological differentiation, did not detect...
The testis consists of two types tissues, the interstitial tissue and seminiferous tubule, which have different functions are assumed to nutritional metabolism. localization enzymes mitochondrial fatty acid β-oxidation system in was investigated obtain a better understanding nutrient metabolism testis. Adult rat tissues were subjected immunoblot analysis for quantitation amounts enzyme proteins, DNA microarray gene expression, immunofluorescence immunoelectron microscopy localization....
Increased levels of lactate, an end-product glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These in lactate can result decreased brain pH, which has implicated patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed five mouse models schizophrenia, bipolar disorder, and autism, suggesting shared endophenotype among these disorders rather than mere artifacts due...
Abstract:
The Golgi apparatus, which plays a role in various biosynthetic pathways, is usually identified electron microscopy by the morphological criteria of lamellae. A 3-dimensional analyses with serial block-face scanning microscope (SBF-SEM), volume-SEM proficient obtaining large volumes data at whole-cell level, could be promising technique for understanding precise distribution and complex ultrastructure although optimal methods such remain unclear since observation can hampered sample charging...
Increased levels of lactate, an end-product glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These in lactate can result decreased brain pH, which has implicated patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed five mouse models schizophrenia, bipolar disorder, and autism, suggesting shared endophenotype among these disorders rather than mere artifacts due...
Increased levels of lactate, an end-product glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These in lactate can result decreased brain pH, which has implicated patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed five mouse models schizophrenia, bipolar disorder, and autism, suggesting shared endophenotype among these disorders rather than mere artifacts due...
Gene expression and localization of nutrient‐metabolizing enzymes in retinal Müller cells were examined order to clarify the meaning fatty acid beta‐oxidation retina. Adult rat tissues isolated from retina subjected western blot analysis, immuno‐fluorescent microscopy immuno‐electron for mitochondrial enzymes. related genes analyzed by DNA microarray. Western analysis on adult microarray showed that all enzyme their gene expressions are present but small amount about 1/10 liver tissue....
Sertoli cells are sustentacular which support spermatogenesis for nutritional metabolism in seminiferous epithelium, however, entire picture has not been clarified yet. The localization and gene expression of enzymes mitochondrial fatty acid beta‐oxidation related were examined, order to characterize the nutrient epithelium. Seminiferous tubules cells, isolated from adult rat testes, subjected light electron microscopic immunohistochemistry DNA microarray. Immunohistochemistry epithelium...
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The development of a tactile sensor for robots is proceeding, whereas, there are many problems such as flexibility and detection area. Human skin has softness, high sensitivity broad receptive field. structure the human gives us effective design sensors. Thus, we focused on subcutaneous tissue, have developed flexible based collagen fiber adipose tissue structure. In this study, verified effectiveness by using FEM analysis.