A5087304694- Ear Surgery and Otitis Media
- Head and Neck Cancer Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Otolaryngology and Infectious Diseases
- Phonetics and Phonology Research
- Radiomics and Machine Learning in Medical Imaging
- Voice and Speech Disorders
- Cancer Diagnosis and Treatment
- Nasal Surgery and Airway Studies
- Bone Tumor Diagnosis and Treatments
- Head and Neck Surgical Oncology
- Facial Nerve Paralysis Treatment and Research
- Esophageal Cancer Research and Treatment
- Hearing Loss and Rehabilitation
- Head and Neck Anomalies
- Cancer Cells and Metastasis
- Biochemical Analysis and Sensing Techniques
- Conducting polymers and applications
- Cellular Mechanics and Interactions
- Nutrition and Health in Aging
- Phonocardiography and Auscultation Techniques
- Lung Cancer Research Studies
- Electron Spin Resonance Studies
- Oral health in cancer treatment
Semmelweis University
2011-2024
Hungarian Academy of Sciences
2008-2014
HUN-REN Institute of Experimental Medicine
2011
Despite great enthusiasm towards immunotherapy, reliable biomarkers are still lacking. The importance of subsets based on human papillomavirus (HPV) status is supported by a growing body evidence. However, role other possible subgroups such as anatomic localization primary tumor remains controversial. Our objective was to investigate immune cell infiltrate and checkpoint inhibitor proteins in above-mentioned head neck cancer subsets. Archival samples 106 laryngeal, oropharyngeal,...
Abstract Purpose The presence of cervical lymph node metastases is one the most influential prognostic factors in head and neck squamous cell carcinomas. management clinically N0 patients with cancer remains controversial: elective dissection has relatively high morbidity, adversely affecting quality life, however, abandoning known to compromise overall survival numerous primaries. purpose this study was evaluate accuracy conventional imaging modalities (CT, MRI, US) fine-needle aspiration...
This study aimed to determine the ability of multimodal evaluation with multiparametric 3T-MRI (MPMRI) and positron emission tomography - computed (PET/CT) detect cancer unknown primary origin (CUP) neck lymph node (LN) metastasis. The group comprised 38 retrospectively analysed consecutive patients LN metastasis in head (HN) region without known tumours (PTs). Statistical values FDG-PET/CT scans were evaluated. Of CUPs, conventional native T1-, T2-weighted STIR sequences detected 6 PTs....
The survival benefit with higher body mass index (BMI) of patients suffering from head and neck squamous cell carcinoma (HNSCC) is documented as BMI paradox. As the early re-nourishment high-risk determine survival, we searched for a nutritional status marker suitable everyday screening. Grouping based on 8th Edition TNM Classification, investigated first time candidate markers among TNM8 subgroups, including newly introduced p16 positive oropharyngeal cancer (OPSCC) patients.
Abstract Purpose Our aim was to determine whether perioperatively administered corticosteroid treatment has any beneficial effect on the outcome of stapes surgery, with special regard audiological results and early postoperative morbidity. Methods 84 CO 2 laser stapedotomies performed in our institute between 2013 2018 were included investigation. All cases underwent preoperative mid-term pure-tone audiometric evaluation. Vestibular complications also evaluated. The subdivided into two...
<i>Objectives and Methods:</i> Tumor dormancy resistance to cytotoxic agents are key limiting events in the treatment of malignant diseases. To determine whether both influenced by extracellular milieu which tumors reside, HT1080 human fibrosarcoma, MCF-7 breast carcinoma OSCORT osteosarcoma cell proliferation, viability, apoptosis cytoreductive-treatment-induced death were investigated presence or absence matrix (ECM). <i>Results:</i> ECM-adherent, but not...
To evaluate the efficacy of ossicular chain reconstruction (OCR) in primary and revision surgeries, to investigate impact number previous surgeries on hearing outcomes.Retrospective analysis cases with OCR due chronic otitis a tertiary center between January 2018 September 2021.Altogether, 147 ossicle involvement were assessed. In 91.83% (n = 135) was performed, 96.26% them titanium TORP/PORP 130), two autologous prosthesis three piston. Mean follow-up 8.8 months. The ABG significantly...
Age-related hearing loss (ARHL), a sensorineural of multifactorial origin, increases its prevalence in aging societies. Besides aids and cochlear implants, there is no FDA approved efficient pharmacotherapy to either cure or prevent ARHL. We hypothesized that selegiline, an antiparkinsonian drug, could be promising candidate for the treatment due complex neuroprotective, antioxidant, antiapoptotic, dopaminergic neurotransmission enhancing effects. monitored by repeated Auditory Brainstem...
Introduction: Head and neck cancers represent a major health problem in Hungary. With their high incidence mortality rates, Hungary is one of the world leaders these indicators. The length patient delay, defined as time from onset symptoms to first medical consultation, unknown Hungarian patients with head cancer. We aimed use representative sample cancer population determine delay according disease localization stage identify correlations other clinical parameters. Methods: In our...
The administration of immune checkpoint inhibitors (ICIs) often leads to immune-related adverse events. However, their effect on auditory function is largely unexplored. Thorough preclinical studies have not been published yet, only sporadic cases and pharmacovigilance reports suggest significance. Here we investigated the anti-PD-1 antibody treatment (4 weeks, intraperitoneally, 200 μg/mouse, 3 times/week) hearing cochlear morphology in C57BL/6J mice. ICI did influence thresholds click or...
Introduction: Tenotomy of the tendon stapedius and tensor tympani (TT) muscles is a minimal-invasive surgical therapeutic procedure in Ménière's disease (MD). It has been assumed that TT medializes stapes into oval window, resulting changes perilymphatic pressures inner ear. By cutting tendons both middle ear muscles, they affect pressure dynamics by not augmenting this even further. Aim: The immediate long-term investigation effect muscle tenotomy on quality life patients suffering from...
Although otitis media with effusion (OME) is a common cause of hearing impairment in children, little known about its microbiological background. We aimed to analyse the microbiome middle ear fluid (MEF) OME identify microbiological, demographic and environmental factors that may potentially influence microbiome. In addition, we compare results conventional culture techniques PCR-based methods.Thirty-nine samples from children were investigated using 16S rRNA sequencing. Bioinformatic...
Introduction Revision stapes surgeries are difficult to perform, and their audiological results inferior primary surgeries. Objective Our goal was identify the most common influential postoperative reasons that cause persistent air-bone gap (ABG) after surgery. focus concentrated on mechanical dysfunctions in middle ear, with special regard adhesion formation. Methods We performed a retrospective case series study 23 cases underwent revision stapedotomies. Results A significant improvement...