Honghai Li

ORCID: 0000-0001-5269-6917
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Research Areas
  • Membrane Separation Technologies
  • Membrane Separation and Gas Transport
  • Graphene and Nanomaterials Applications
  • Plant Molecular Biology Research
  • Covalent Organic Framework Applications
  • Membrane-based Ion Separation Techniques
  • X-ray Diffraction in Crystallography
  • Electrospun Nanofibers in Biomedical Applications
  • Cancer-related molecular mechanisms research
  • Crystallization and Solubility Studies
  • Traditional Chinese Medicine Studies
  • Ubiquitin and proteasome pathways
  • Neurological Disease Mechanisms and Treatments
  • MicroRNA in disease regulation
  • Ginger and Zingiberaceae research
  • Postharvest Quality and Shelf Life Management
  • interferon and immune responses
  • Autophagy in Disease and Therapy
  • Traditional Chinese Medicine Analysis
  • Biochemical and biochemical processes
  • Vitamin D Research Studies
  • Cell death mechanisms and regulation
  • Photosynthetic Processes and Mechanisms
  • Plant Stress Responses and Tolerance
  • Acupuncture Treatment Research Studies

Shaoxing People's Hospital
2023-2024

Southwest University
2024

Beijing Information Science & Technology University
2023-2024

Qingdao University of Science and Technology
2010-2023

Sichuan Academy of Forestry
2023

Korea University Medical Center
2023

Chongqing University
2019-2022

Chinese Academy of Sciences
2020-2021

East China University of Science and Technology
2020-2021

Qingdao Center of Resource Chemistry and New Materials
2021

<h3>Background</h3> The rapid spread of multidrug-resistant tuberculosis (MDR-TB) has attracted global concerns. This study aimed to identify factors contributing the high prevalence MDR-TB in China9s Heilongjiang province. <h3>Methods</h3> A cross-sectional survey following WHO/International Union Against Tuberculosis and Lung Disease guidelines was conducted with consecutive recruitment patients TB 30 counties selected at random 2004. total 1995 were tested for MDR-TB. Factors associated...

10.1136/thoraxjnl-2011-200018 article EN Thorax 2012-03-08

Abstract Ginger (Zingiber officinale), the type species of Zingiberaceae, is one most widespread medicinal plants and spices. Here, we report a high-quality, chromosome-scale reference genome ginger ‘Zhugen’, traditionally cultivated in Southwest China used as fresh vegetable, assembled from PacBio long reads, Illumina short high-throughput chromosome conformation capture (Hi-C) reads. The was phased into two haplotypes, haplotype 1 (1.53 Gb with contig N50 4.68 M) 0 (1.51 5.28 M)....

10.1038/s41438-021-00627-7 article EN cc-by Horticulture Research 2021-08-05

Ascorbic acid (AsA) is a multifunctional phytonutrient that essential for the human diet as well plant development. While much known about AsA biosynthesis in plants, how this process regulated tomato (Solanum lycopersicum) fruits remains unclear. Here, we found auxin treatment inhibited accumulation leaves and pericarps of tomato. The response factor gene SlARF4 induced by to mediate auxin-induced inhibition accumulation. Specifically, transcriptionally inhibits transcription SlMYB11,...

10.1093/plcell/koac262 article EN The Plant Cell 2022-08-24

Abstract The phytohormone ethylene is well known for its important role in the ripening of climacteric fruit, such as tomato (Solanum lycopersicum). However, and mode action other plant hormones fruit regulation are not fully understood. Here, we showed that exogenous GA treatment or increasing endogenous gibberellin content by overexpressing synthesis gene SlGA3ox2 specifically tissues delayed ripening, whereas with biosynthesis inhibitor paclobutrazol (PAC) accelerated ripening. Moreover,...

10.1093/hr/uhad275 article EN cc-by Horticulture Research 2023-12-18

Background & Aims: RNA interference (RNAi) is a powerful tool to silence gene expression. The adenoviral vector expressing small interfering (siRNA) highly effective in mammalian cells. However, its potential use as therapeutic target an oncogene specifically remains be seen. We applied the adenovirus-delivered siRNA (AdSiRNA) inhibit hepatocellular carcinoma (HCC) oncogene, p28GANK, HCC cell lines and investigated antitumor effects. Methods: T7-RNA polymerase system was used screen specific...

10.1053/j.gastro.2005.03.001 article EN cc-by Gastroenterology 2005-06-01

Tomato (Solanum lycopersicum) is a model plant for studying fruit development and ripening. In this study, we found that down-regulation of tomato bell-like homeodomain 4 (SlBL4) resulted in slightly darker-green phenotype increased accumulation starch, fructose, glucose. Analysis chlorophyll content TEM observations was consistent with these phenotypes, indicating SlBL4 involved chloroplast formation. Ripened SlBL4-RNAi plants had noticeably decreased firmness, larger intercellular spaces,...

10.1093/jxb/eraa272 article EN Journal of Experimental Botany 2020-05-29

The phenomenon of drug burst release is the main problem in field delivery systems, as it means that a good therapeutic effect cannot be acheived. Nanofibers developed by electrospinning technology have large specific surface areas, high porosity, and easily controlled morphology. They are being considered potential carriers for sustained release. In this paper, we obtained polycaprolactone (PCL)/polylactic acid (PLA) core-shell porous drug-carrying nanofibers using coaxial...

10.3390/nano11051316 article EN cc-by Nanomaterials 2021-05-17

Abstract Aluminum (Al) exists naturally in air, water, and soil, also our diet. Al can be absorbed into the human body accumulates different tissues, which has been linked to occurrence of Alzheimer's disease various neurological disorders. By using Vicia cytogenetic tests, are commonly used monitor genotoxicity environmental pollutants, effects aluminum (AlCl 3 ) were investigated this study. Present results showed that caused significant increases frequencies micronuclei (MN) anaphase...

10.1002/tox.20482 article EN Environmental Toxicology 2009-03-09

Capsaicin, main pungent ingredient of hot chilli peppers, has been shown to have anticarcinogenic effect on various cancer cells through multiple mechanisms. In this study, we investigated the apoptotic capsaicin human pancreatic in both vitro and vivo systems, as well possible mechanisms involved. , treatment (PANC-1 SW1990) with resulted growth inhibition, G0/G1 phase arrest, apoptosis a dose-dependent manner. Knockdown arrest- DNA damage-inducible gene 153 (GADD153), marker...

10.1155/2013/629750 article EN Evidence-based Complementary and Alternative Medicine 2013-01-01

Gemcitabine is currently the best treatment available for pancreatic cancer (PaCa); however, patients with disease develop resistance to drug over time. Agents that can either enhance effects of gemcitabine or overcome chemoresistance are required PaCa. Oridonin one such agent which safe and multitargeted, has been linked suppression survival, proliferation, invasion angiogenesis cancer. In this study, we investigated whether oridonin could sensitize PaCa in vitro vivo. vitro, inhibited...

10.3892/ijo.2012.1519 article EN International Journal of Oncology 2012-06-14

Current wound dressings have poor antimicrobial activities and are difficult to degrade. Therefore, biodegradable antibacterial urgently needed. In this article, we used the hydrothermal method side-by-side electrospinning technology prepare a gelatin mat with incorporated zinc oxide/graphene oxide (ZnO/GO) nanocomposites. The resultant fibers were characterized by field emission environment scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDX), diffractometry...

10.3390/molecules25051043 article EN cc-by Molecules 2020-02-26
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