A5101792503- Phytochemistry and biological activity of medicinal plants
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Ovarian cancer diagnosis and treatment
- Circular RNAs in diseases
- Click Chemistry and Applications
- Cell death mechanisms and regulation
- Pelvic floor disorders treatments
- Urinary and Genital Oncology Studies
- Polymer crystallization and properties
- Autophagy in Disease and Therapy
- Synthesis and biological activity
- Endometrial and Cervical Cancer Treatments
- Cancer Risks and Factors
- Calcium signaling and nucleotide metabolism
- Urological Disorders and Treatments
- X-ray Diffraction in Crystallography
- Quinazolinone synthesis and applications
- RNA Research and Splicing
- HIV Research and Treatment
- Protein Degradation and Inhibitors
- Bioactive Compounds and Antitumor Agents
- Microtubule and mitosis dynamics
- Land Rights and Reforms
China Medical University
2006-2024
Sichuan University
2010-2021
West China Hospital of Sichuan University
2021
Wenzhou Medical University
2012-2013
Capsaicin, one of the major pungent ingredients found in red peppers, has been recently demonstrated to induce apoptosis various malignant cell lines through an unclear mechanism. In this study, effect capsaicin on proliferation and human pancreatic cancer line PANC‑1 its possible mechanism(s) action were investigated. The results a Cell Counting Kit-8 (CCK‑8) assay revealed that significantly decreased viability cells dose-dependent manner. Capsaicin induced G0/G1 phase cycle arrest as by...
Background Dyschromatosis symmetrica hereditaria (DSH, MIM 127400) is a dominantly inherited skin disease associated with mutations in ADAR, the gene that encodes double‐stranded RNA‐specific adenosine deaminase. We previously reported two novel ADAR (p.Q513X and p.R916W) confirmed role of Chinese patients DSH. Both haploinsufficiency dominant‐negative effect have been suggested as potential mechanism by which cause Objectives To identify additional DSH families to obtain insight into...
Capsaicin, main pungent ingredient of hot chilli peppers, has been shown to have anticarcinogenic effect on various cancer cells through multiple mechanisms. In this study, we investigated the apoptotic capsaicin human pancreatic in both vitro and vivo systems, as well possible mechanisms involved. , treatment (PANC-1 SW1990) with resulted growth inhibition, G0/G1 phase arrest, apoptosis a dose-dependent manner. Knockdown arrest- DNA damage-inducible gene 153 (GADD153), marker...
The aim of this study was to evaluate whether emodin can overcome the chemoresistance gemcitabine-resistant cancer cell line (Bxpc-3/Gem) in vitro. Bxpc-3/Gem derived from human pancreatic Bxpc-3. We found that cells were characterized by a series morphological changes with resistance index 43.51 comparing parental line. Emodin reduced proliferation dose-dependent manner. and gemcitabine combination treatments resulted decreased increased apoptosis cells. In addition, downregulation gene...
Gemcitabine is currently the best treatment available for pancreatic cancer (PaCa); however, patients with disease develop resistance to drug over time. Agents that can either enhance effects of gemcitabine or overcome chemoresistance are required PaCa. Oridonin one such agent which safe and multitargeted, has been linked suppression survival, proliferation, invasion angiogenesis cancer. In this study, we investigated whether oridonin could sensitize PaCa in vitro vivo. vitro, inhibited...
Abstract: Ovarian cancer accounts for the major part of mortality attributable to female reproductive system malignant tumors worldwide. Recently, incidence ovarian has been increasing annually, and there remains a lack suitable treatment methods that can significantly improve 5-year survival rates patients. Therefore, it is necessary identify more effective treatments cancer. It established microRNAs (miRNAs) have important roles in diagnosis specific miRNA, miR-762, promote development...
The Rab GTPase family protein Rab14 has been implicated in cancer development. However, its clinical significance ovarian cancers and biological effects have not examined. present study aims to examine the significance, roles, molecular mechanism of progression. We examined expression pattern 122 cases specimens using immunohistochemistry found overexpression correlated with FIGO stage (p = 0.0041). depleted SKOV3 cells siRNA overexpressed SW626 cells. Knockdown inhibited cell growth...
Paclitaxel (PTX) resistance is a great obstacle for the treatment of ovarian cancer. A previous study indicated that tetrandrine (TET) could induce apoptosis cancer cells. This aimed to explore effect TET in combination with PTX on cells.CCK-8 assay, flow cytometry and wound healing assays were used detect proliferation, migration PTX-resistant SKOV3 cells (SKOV3/PTX). The expressions Bax, Bcl-2, cleaved caspase 3, β-catenin, c-Myc, cyclin D1 p21 SKOV3/PTX detected Western blot. In vivo...
Background: Dairy product consumption is associated with ovarian cancer (OC) incidence. However, limited evidence available on its influence OC mortality. Methods: The association between pre-diagnostic dairy intake and mortality was investigated in the follow-up study, which included a hospital-based cohort (n = 853) of women diagnosed epithelial 2015 2020. Pre-diagnosis diet information collected using validated food frequency questionnaire. Deaths were ascertained up to March 31, 2021 via...
MUC1 is a type I transmembrane glycoprotein and overexpressed in various epithelial tumor tissues. Some researchers have demonstrated that the glycosylation status of can affect MUC1-mediated growth cell differentiation. In our previous study, we proved abilities proliferation, adhesion, invasion metastasis, drug resistance were enhanced ovarian cancer cells stably expressing Lewis(y). Therefore, hypothesized Lewis(y) antigen may play central role regulating expression, differentiation be...
Abstract Objective Long non-coding RNAs (lncRNAs) and microRNAs (miRs) are differentially expressed in ovarian cancer (OC) cells influence OC progression. This study intended to explore the underlying roles of LINC00115 miR-30a OC. Methods Gene Expression Omnibus database was used find microarray datasets bioinformatics analysis predicted potential molecular mechanism stem (OCSCs) surface marker isolated from human cell line identified. CD133 + OCSCs were transfected with LINC00115, SOX9...
The relationship between intake of fish and n-3 fatty acids endometrial cancer risk has not been consistent across epidemiological studies. We quantitatively assessed the aforementioned association through a systematic review meta-analysis. PubMed Embase were searched March 2017 for eligible Fixed or random-effects models used to pool relative risks (RRs) 95% confidence intervals (CIs). dose-response was also evaluated. Based on literature search, five prospective studies 11 case-control...
The aims of this retrospective study were to determine the accuracy transvaginal sonography for diagnosing cystitis glandularis in women and describe sonographic features masses confirmed cases. For 90 patients with clinically or sonographically suspected glandularis, we retrospectively reviewed imaging files. Twenty-one cases by histopathologic examination. All had undergone evaluate bladder a standardized manner no more than 1 week before Findings from preoperative described compared...
Squalene synthase (SQS) is the key precursor in synthesis of cholesterol. Located downstream relation to hydroxy methylglutaryl coenzyme A reductase and having no influence on formation biologically necessary isoprenoids make it an interesting target for development cholesterol lowering drugs with fewer side effects. To discover novel SQS inhibitors, three‐dimensional quantitative structure‐activity relationship pharmacophore models were built further validated by cost function analysis,...
Bromodomain is a recognition module in the signal transduction of acetylated histone. BRD 4, one bromodomain members, emerging as an attractive therapeutic target for several types cancer. Therefore, this study, attempt has been made to screen compounds from integrated database containing 5.5 million 4 inhibitors using pharmacophore‐based virtual screening, molecular docking, and dynamics simulations. As result, two molecules twelve hits were found be active bioactivity tests. Among...