A5040018416- Genomics and Chromatin Dynamics
- Chemical Synthesis and Analysis
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Computational Drug Discovery Methods
- Plant Molecular Biology Research
- Estrogen and related hormone effects
- Enzyme Structure and Function
- Crystal structures of chemical compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- NF-κB Signaling Pathways
- S100 Proteins and Annexins
- Plant nutrient uptake and metabolism
- Radiopharmaceutical Chemistry and Applications
- Aerogels and thermal insulation
- Synthesis and Catalytic Reactions
- Mesoporous Materials and Catalysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Ubiquitin and proteasome pathways
- Medicinal Plant Pharmacodynamics Research
- Energetic Materials and Combustion
- Chromatin Remodeling and Cancer
- Genomic variations and chromosomal abnormalities
- Cytokine Signaling Pathways and Interactions
Institut de génétique et de biologie moléculaire et cellulaire
2023
Inserm
2023
Centre National pour la Recherche Scientifique et Technique (CNRST)
2023
Université de Strasbourg
2023
University of Ottawa
2012-2017
Cornell University
2012
New York University
2006-2010
University of Padua
2005
Histone variants have been proposed to act as determinants for posttranslational modifications with widespread regulatory functions. We identify a histone-modifying enzyme that selectively methylates the replication-dependent histone H3 variant H3.1. The crystal structure of SET domain lysine-27 (H3K27) methyltransferase ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (ATXR5) in complex H3.1 peptide shows ATXR5 contains bipartite catalytic specifically "reads" alanine-31 Variation at position 31...
In plants, the histone H3.1 lysine 27 (H3K27) mono-methyltransferases ARABIDOPSIS TRITHORAX RELATED PROTEIN 5 and 6 (ATXR5/6) regulate heterochromatic DNA replication genome stability. Our initial studies showed that ATXR5/6 discriminate between H3 variants preferentially methylate K27 on H3.1. this study, we report three regulatory mechanisms contributing to specificity of ATXR5/6. First, show ATXR5 methylates R/F-K*-S/C-G/A-P/C motif with striking preference for hydrophobic aromatic...
ABSTRACT BCL7 proteins are among the most recently identified subunits of mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complex and absent from unicellular version complex. Mutations in associated with different kind cancers including blood malignancies. The information on molecular function structure is to date very limited. Here we report that directly bind nucleosome core particle (NCP) free DNA high affinity. We demonstrate form defined complexes NCP identify conserved N-terminal...