A5019739502- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal and Anal Carcinomas
- Pregnancy and preeclampsia studies
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- Adrenal Hormones and Disorders
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Gestational Diabetes Research and Management
- Cancer Immunotherapy and Biomarkers
- Brain Metastases and Treatment
- Birth, Development, and Health
- Palliative Care and End-of-Life Issues
- Renal function and acid-base balance
- COVID-19 Clinical Research Studies
- COVID-19 Impact on Reproduction
- Genetic factors in colorectal cancer
- Pelvic and Acetabular Injuries
- HER2/EGFR in Cancer Research
- Cancer survivorship and care
- Cellular transport and secretion
IRCCS Materno Infantile Burlo Garofolo
2021-2025
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2015-2022
Aziende Socio Sanitarie Territoriale dei Sette Laghi
2020
European Institute of Oncology
2006-2016
University of Milan
1985-2016
Luigi Sacco Hospital
2011-2014
Ripamonti
2007-2011
San Raffaele University of Rome
2002
Sanofi (France)
2001
Vita-Salute San Raffaele University
1995
Elevated levels of circulating chromogranin A (CgA), a protein stored in the secretory granules many neuroendocrine cells and neurons, have been detected blood patients with tumors or heart failure. The pathophysiological role increased secretion CgA is unknown. Using mice bearing subcutaneous genetically engineered to secrete circulation, we found that this prevent vascular leakage induced by tumor necrosis factor-alpha (TNF) liver venous system. Structure-activity studies, carried out...
We have investigated the role of p55 and p75 tumor necrosis factor receptors 1 2 (TNFR1 TNFR2, respectively) in TNF-induced alteration endothelial permeability vitro vivo. Stimulation TNFR1 with an agonist antibody or a receptor-selective TNF mutein increased flux 125 I-albumin through cell monolayers. An antagonist anti-TNFR1 antibody, but not anti-TNFR2 antibodies, blocked activity vitro. TNFR1, induced cytoskeletal reorganization associated permeability. SB-203580, p38 mitogen-activated...
Preoperative endocrine therapy is effective in postmenopausal patients with breast cancers expressing oestrogen receptor. We investigated the activity of primary letrozole combination GnRH analogue premenopausal women T2–T4 N0–N2 cancer, whose tumours expressed and progesterone receptors. measured expression molecular factors involved responsiveness to agents including ERα, EGFR, HER2, MAP kinases (and phosphorylated forms) ER-β1, both at initial biopsy time surgery. Thirty-five were...
Gefitinib, an orally active inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, combined with chemotherapy, has shown efficacy as second-line treatment for advanced colorectal cancer (CRC). Gefitinib FOLFOX6 (oxaliplatin plus folinic acid and 5-fluorouracil) was tested a first-line therapy.Patients metastatic EGFR-positive CRC received gefitinib at dose 250 mg/day simplified FOLFOX6. continued maintenance in nonprogressing patients. Responses were assessed by Response...
Mild hyponatremia is frequently encountered in the pediatric emergency department (PED). Although usually of little clinical concern, its prognostic meaning as a possible marker more severe disease has not yet been well established.We retrospectively analyzed data from children and adolescents who performed blood sample with plasmatic sodium measurement on admission to PED IRCCS "Burlo Garofolo" Pediatric Hospital Trieste, Italy, 2019. We compared rate, length admissions laboratory...
Abstract Background The primary aim of this study was to compare the quality life between women with obstetric anal sphincter injury (OASI) and intact perineum or minor vaginal tears following their first birth through a validated urogynaecological questionnaire. As secondary aim, we wanted identify specific symptoms for pelvic floor dysfunction after birth. Methods One hundred thirty-three cases (III- IV-degree tears) 133 controls (intact I- II-degree tear) were asked fill PFDI-20...
Chronic school absenteeism is a common problem in childhood and adolescence, it frequently observed patients with somatic symptom related disorders (SSRDs). This study aimed to determine whether what extent the presence of may be risk factor for diagnosis SSRDs hospitalised patients. matched cohort included children adolescents aged between 8 17 years, admitted paediatric ward IRCCS Burlo Garofolo Trieste from 2021 2023, who were divided into two groups, first including at least 15 days...
We describe here a case of pure gastric yolk sac tumor (YST). A 62-year-old patient underwent gastrectomy with D2 dissection. The histological report confirmed the diagnosis YST and that two 14 regional lymph nodes removed were metastatic. Three courses PEB regimen chemotherapy delivered subsequently. months later experienced dysphagia from stenosis anastomosis computerized tomography scan showed recurrence peritoneal nodules; died one year after surgery. origin is unclear but involvement...