A5070609263- Acute Myeloid Leukemia Research
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Hemoglobinopathies and Related Disorders
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Iron Metabolism and Disorders
- Hematopoietic Stem Cell Transplantation
- MRI in cancer diagnosis
- Mosquito-borne diseases and control
- Erythropoietin and Anemia Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Radiomics and Machine Learning in Medical Imaging
- Dialysis and Renal Disease Management
- interferon and immune responses
- Viral Infections and Vectors
- Vitamin C and Antioxidants Research
- Lymphoma Diagnosis and Treatment
Huashan Hospital
2017-2024
Fudan University
2017-2024
First Hospital of Jilin University
2022
Jilin University
2022
New York University
2019-2020
It remains uncertain whether vitamin C routinely used with oral iron supplements is essential for patients deficiency anemia (IDA).To compare the equivalence and assess safety of plus or alone in IDA.This single-center, open-label, randomized clinical trial was conducted from January 1, 2016, to December 30, 2017, Huashan Hospital, Fudan University. Adult newly diagnosed IDA were enrolled. Participants randomly assigned (1:1) group supplements-only group. Data analysis performed March...
A multi-center study from the French Myelodysplastic Syndrome (MDS) Group confirmed that iron chelation therapy is an independent prognostic factor can increase survival rate of patients who are suffering transfusion-dependent low-risk MDS. In this study, we aimed to explore clinical phenomena in vitro, by exploring synergistic effect chelator Deferasirox (DFX) and DNA methyl transferase inhibitor Decitabine (DAC) leukemia cell lines SKM-1, THP-1, K-562. Treatment with both DFX or DAC...
In our previous study, the 4‑aminobutyrate aminotransferase (ABAT) gene was screened and selected as a target that may affect prognosis of myelodysplastic syndrome (MDS). The present study aimed to determine prognostic value ABAT in 152 patients with MDS, 29 acute myeloid leukemia (AML) 40 controls, by detecting expression methylation levels gene. were significantly reduced compared controls (P<0.0001), degree DNA increased MDS subjects (P<0.0001). Age, hemoglobin level, marrow blasts,...
Iron deficiency anemia (IDA) affects more than 1.2 billion individuals globally. In addition to anemia, reactive thrombocytosis is also a common clinical hematological condition in patients with IDA. However, some case reports have described the thrombotic complications association IDA-induced thrombocytosis. Patients high risk of thrombosis need prompt identification and effective treatment prevent complications. While iron replacement has been shown decrease platelet count this context,...
Acute megakaryocytic leukemia (AMKL) is a rare subtype of acute myeloid (AML), which challenging to diagnose due frequent myelofibrosis (MF) and low percentage blast cells. In the present study, clinical characteristics experimental observations in 9 adult patients diagnosed with AMKL, who were recruited by Sino‑U.S. Shanghai Leukemia Co‑operative Group, analyzed order summarize diagnostic experience provide recommendations on diagnosing AMKL. All according 2008 World Health Organization...
Long non-coding RNAs (lncRNAs) play important roles in hematological malignancies. We have previously identified several differentially expressed lncRNAs myelodysplastic syndromes (MDS) by microarray analysis. In the present study, we explored regulatory circuitry, potential functions, clinical and prognostic relevance of these MDS developing a lncRNA regulation network. novel lncRNA, LOC101928834, which was significantly up-regulated bone marrow patients with acute myeloid leukemia (AML)....
Circular RNAs (circRNAs) have been identified to exert vital biological functions and can be used as new biomarkers in a number of tumors. However, little is known about the circRNAs myelodysplastic syndrome (MDS). Here, we aimed investigate circRNA expression profiles functional clinical value MDS. Differential between MDS control subjects was analyzed using arrays, which 145 upregulated 224 downregulated circRNAs. Validated by real-time quantitative PCR 100 patients 20 controls, three...
IncRNAs play an important role in the regulation of gene expression. The present study profiled differentially expressed lncRNAs (DELs) and mRNAs (DEMs) myelodysplastic syndrome (MDS) to construct a 4‑aminobutyrate aminotransferase (ABAT)‑DEL‑DEM co‑expression network MDS development using Agilent human BeadChips Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses. Compared with controls, there were 543 DELs 2,705 DEMs patients, among which 285 (52.5%) downregulated...
This study is aimed at determining the ability of computed tomography- (CT-) based radiomic analysis to distinguish between grade 0/1 and 2/3 macrovesicular steatosis (MaS) in cadaveric donor liver transplantation cases. Preoperative noncontrast-enhanced CT images 150 patients with biopsy-confirmed MaS were analyzed retrospectively; these classified into low-grade (n = 100, 0 or 1) high-grade 50, 2 3) groups. Three-dimensional spherical regions interest 40 pixel (2.5 cm) diameter placed...
The factors that affect hypomethylating agents (HMAs) sensitivity in myelodysplastic syndrome (MDS) are complex and multifaceted. They include DNA methylation, gene expression, mutation, etc. However, the underlying mechanisms still not clearly illustrated. In present work, ABAT expression was associated with HMAs sensitivity. It found interference increased of HL-60 THP-1 cells to treatment, while overexpression decreased its RNA-sequencing analysis showed knockdown activated both...
This study was to detect expression levels of circular RNA (circRNA) in bone marrow (BM) and peripheral blood (PB) patients with refractory cytopenia multilineage dysplasia (RCMD). The objective identify circRNAs potential diagnostic value investigate the correlation between these BM PB RCMD patients.We first analyzed 5 4 control subjects using circRNA arrays. We found 369 were differentially expressed two groups; 145 upregulated 224 down regulated. Using a set stringent criteria, we...